Worldly Portent of Face Uncovering and Women’s Dilapidation: A Comparative Study in Context With Quranic Injunctions

Assyrian Text is witnessed that women used veil for face covering with an additional piece of cloth about 13 centuries before the Christ. Then history of mankind displays veil in Egyptian society that was transparent and normally white in color. We found a handful evidences in Greek literature regarding veiling of face. History travels to Anglo-Saxon age and witnessed that women used veil to cover their hair of head. The head covering shows a biological reasoning also. Roman culture was the culture of fantasy, the veils were full of colorful, and multi designed veil arranged by flowers and different beautiful substantial. In Roman, veil developed from only head covering to shoulder covering and then from head to back covering. British regime also enrich the history of veil. There was beautiful designed, decorated with net clothes and covered with beautiful embroidery. The veil was empowered by elite community in England. Later it was popularized as a fashion in colonial communities. Through this thorough historic discussion, it is approved that veil used by women has a long history as the human history. In religious context, Hinduism is understood as the oldest religion on globe, it is found that in Harappan times about 2500 BC, Aryan women used to wear full body covering single cloth from head covering to foot, which was preached in Hindu religious book Vedas also, later the single cloth was known as Sari. And after the introduction of Christianity, Veil was introduced as a compulsory symbol of religion. Veil of whole body with strict rules can be seen in the form of Christian nun. Later, Islam explained veil of women in public as an obligatory sign. Islam is the youngest religion on earth, it was published rapidly and the implication of its rules are practiced prominently. After a thorough historic and religious discussion, it if proved in this article that veil was a compulsory part of human society and religions before Islam had also preached for veiling.  

Genome Wide Mapping of Chromatin States Based on Histone Combinatorics for Determination of Epigenetic Expression

Histone proteins wrap DNA around in small globular entities commonly known as nucleosomes. The post translational modifications to the histone tails are referred as histone modifications (HMs). The regulation of DNA in order to access the transcription machinery is epigenetically programmed by specific DNA and chromatin covalent modifications. HMs could either be present or absent at particular genomic loci and the combinatorial patterns of the specific modifications being addressed as ‘histone codes’, are believed to co-regulate significant biological processes. Regions defined by combinatorial patterns of marks can be referred to as chromatin states. Chromatin states associated with genomic locations correlate with specific functional elements as enhancers, transcription start sites, which can be exclusively inferred from successive combinations of chromatin marks in their contiguous locations. Biologically significant combinatorics of epigenetic modifications and their subsequent functional interplay are still mostly unrevealed. We aimed to use ChIP-Seq data of Histone modifications at different genomic loci to highlight the unbiased genomic grouping and to decode the complex biological network of HMs in association with other chromatin players in defining various chromatin states. We used different tools and techniques to accomplish our task. Complex biological networks underlying the hidden chromatin states were revealed via merging machine learning and graph theory existing approaches. Histone modification efficient and simple combinatorics was studied at a global and local scale by developing and implementing a clustering and biclustering tool. Results have been compared with the existing approaches. Meanwhile a simple and efficient computational methodology for efficient chromatin states identification for ChromHMM (HMM based chromatin segmentation) has also been developed by utilizing Hidden Markov Models components. As a result of above study we revealed the role of various factors in maintaining the chromatin state connectivity via focusing chromatin state networks. Our studies highlighted the minimum dominating nodes set and various hubs in chromatin state networks focusing their interaction patterns. Along with we developed and tested a clustering tool ChromClust and a biclustering tool ChromBiSim to highlight histone combinatorics in binarized signal data in an efficient and interactive way. ChromClust operates at global level while ChromBiSim mines local patterns of histone modifications associations. We conclude that epigenomic landscape is portrayed as interplay of various factors including histone combinations, transcription factors, chromatin modifiers and most importantly the underlying DNA motifs. Each chromatin state has a specific set of these factors which interact with each other to mark that state hence creating the whole chromatin states network.