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Home > Analysis of Rb2 Protein Expression Levels in Breast Cancer Patients

Analysis of Rb2 Protein Expression Levels in Breast Cancer Patients

Thesis Info

Author

Farheen Saeed Khan

Supervisor

Muhammad Saeed

Department

Department of Biosciences

Program

RBM

Institute

COMSATS University Islamabad

Institute Type

Public

City

Islamabad

Province

Islamabad

Country

Pakistan

Thesis Completing Year

2015

Thesis Completion Status

Completed

Subject

Biosciences

Language

English

Added

2021-02-17 19:49:13

Modified

2023-01-06 19:20:37

ARI ID

1676719642181

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تانیثیت،جنسیت،حقیقت نگاری

تانیثیت
تانیثیت کا تعلق براہِ راست عورت اور اس کے حقوق سے ہے۔تانیثی تحریک کا بنیادی مقصد عورتوں کو مردوں کے برابرسیاسی ، سماجی ، معاشرتی، معاشی اور قانونی برابری دینا۔ تانیثی تحریک عورتوں کے لیے انصاف کی طالب ہے ، معاشرے میں رائج مختلف امتیازات کے خاتمے کا اعلان کرتی ہے۔اردو افسانے میں نمائندہ خواتین افسانہ نگاروں کے ہاں تانیثی ر جحان دیکھنے کو ملتا ہے۔ جہاں عورتیں سماجی، معاشی ، سیاسی، معاشرتی اور علاقائی مسائل پر قلم اٹھا رہی ہیں اس کے ساتھ ساتھ عورتوں کے ساتھ پیش آنے والے مسائل کو بھی قلم بند کر رہی ہیں۔اس ضمن میں غور کریں تو ذکیہ مشہدی ایک معتبر نام ہے۔ انہوں نے عورتوں کی زندگی کو بڑی فنکاری سے پیش کیا۔ان کو افسانہ’’تھکے پاؤں‘‘اور’’حصار‘‘تانیثی پہلو سے ان کے بہترین افسانے ہیں۔نسائی زندگی کو بیان کرنے والی ایک اور اہم افسانہ نگار ترنم ریاض بھی ہیں۔ترنم ریاض کی عورت مشرقی تہذیب کی نمائندگی بھی کرتی ہے اور بغاوت کا جذبہ بھی رکھتی ہے۔ ان کا افسانہ’’ ہم تو ڈوبے صنم‘‘ اسی قسم کا افسانہ ہے۔ ا س کے علاوہ نگار عظیم،شائستہ فخری،غزالہ ضیغم اور دیگر افسانہ نگاروں نے عورتوں کے حوالے سے اپنے خیال کو جس طرح تخلیق کی شکل میں ابھارا ہے اس میں ہندوستانی عورت کے تمام حالات اجاگر ہوتے ہیں۔
جنسیت
انگارے کے مصنفین نے پہلی بار سماجی مسائل کو مغربی زاویۂ نگاہ سے دیکھا۔انہوں نے ادب اور سماج کے بندھے ٹکے اصول واقدار سے انحراف کرتے ہوئے جنسی بھوک،ذہنی پریشانیوں نفسیاتی الجھنوں کو شعورکے پردے میں اجاگر کیا۔انہوں نے سماجی لبادہ اوڑھے چہروں کو بے نقاب کیا اور ان کی گھناؤنی ذہنیت کو اپنے افسانوں میں پیش کیا ہے۔اس سلسلے میں سجاد ظہیر کا افسانہ ’’دالری‘‘ اور احمد علی کا افسانہ’’بادل نہیں آتے‘‘ پیش کیے جا سکتے ہیں۔ رشید جہاں اردو کی...

Investigation of Microstructure and Stress Corrosion Cracking in Al-6061-T6 Alloy at Different Loads

Stress corrosion cracking (SCC) refers to the damage of mechanical components which are under the combined action of static load and corrosive environment. This phenomenon occurs in various applications including naval and aerospace industry where aluminum and steel alloys experience mechanical loadings in the presence of corrosive environments. In this research work, microstructural and environmental influence on corrosion behavior of Al-6061-T6 at different static loads was investigated. A new test fixture was developed for stress corrosion cracking. Dog-bone shaped tensile specimens of Al-6061-T6 were manufactured using CNC milling machine. Tests were conducted at constant loads of 200 N, 500 N and 800 N, in three different environments: dry ambient conditions, distilled water and 3.5% NaCl solution. Testing continued for different intervals of time i.e. 96 hours, 68 hours and 4.5 hours respectively. After each set of experiments, specimens were observed for cracks using metallurgical microscope. Detailed fractographic investigation of all the tested specimens was carried out using Scanning Electron Microscope (SEM). Excessive corrosion and material degradation was observed in specimens tested in distilled water and 3.5% NaCl environments. Microstructural analysis depicted pitting corrosion and crack deformation.  Some regions clearly showed that grain boundaries were attacked due to oxidation and chemical attack causing weakening of grain boundaries and resulted into intergranular corrosion. Precipitates and grain boundaries in Al-6061-T6 served as a reason of crack initiation due to hydrogen diffusion. Fractographic investigation provided the evidence of trans granular fracture as well as intergranular fracture which was observed as dimples and extensive ductile tearing.

Difference in the Level of Utilization and Determinants of Preconception Care Among Pregnant Women in Aga Khan University Hospital and Maragua Level Four Hospital.

Background: Preconception care (PCC) is an important form of primary health care that aims to identify risks, offer patient education and evidence based interventions prior to conception in order to improve maternal and fetal short and long term health outcomes. Despite the benefits of PCC, the global levels of utilization are still low, more so in developing countries and in the rural settings. This study aimed to determine the difference in the level and determinants of PCC in both urban and rural settings in Kenya. Objectives: The primary objective of this study was to compare PCC among pregnant women in Aga Khan University Hospital, Nairobi (AKUH, N) (urban) and Maragua Level Four Hospital (MLFH) (rural). The secondary objective was to determine the factors affecting PCC among pregnant women in the two hospitals. Design and Methodology: Unselected pregnant women seeking antenatal care (ANC) were recruited consecutively at the Mother and Child Health (MCH) clinics in AKUH, N and MLFH. The study design was a mixed method study that employed a cross-sectional approach to determine the level of PCC, using a 5-10 minutes self-administered questionnaire, and a qualitative approach to assess factors affecting PCC using a semi-structured interview guide. Quantitative data was analyzed using SPSS version 22. Qualitative interviews were transcribed verbatim, a thematic framework was thereafter manually constructed through coding, creating categories, sub-themes and themes. Indexing, charting, mapping and data interpretation were thereafter carried out. Results: A total of 194 pregnant women were recruited, 97 in each setting (rural and urban). Of these, 21 women were selected through purposive sampling to participate in in-depth interviews for the qualitative aspect of the study. Saturation of themes occurred after 13 interviews (7 at AKUH and 6 at MLFH) after which 4 more interviews were conducted at each site to confirm saturation. Of the total participants, 25.8% received PCC. There was a significant difference (p < 0.01) in PCC between the rural and urban participants with an OR of 0.3 (0.19-0.72, 95 % CI). Univariate analysis of possible related factors showed that age, marital status, education, parity and occupation had potential effect on PCC. Transcription, coding and thematic analysis of the in-depth interviews yielded 97 categories which were merged into 39 sub-themes and subsequently into 12 main themes. Eleven of the main themes were identified as factors affecting PCC while one theme contained suggested strategies of increasing PCC awareness and utilization. The dominant themes