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Exploring Lncrnas Sequence, Structure and Function Relationships

Thesis Info

Author

Himal Naveed

Supervisor

Abdullah Bilal Ahmed

Department

Department of Biosciences

Program

RBI

Institute

COMSATS University Islamabad

Institute Type

Public

City

Islamabad

Province

Islamabad

Country

Pakistan

Thesis Completing Year

2016

Thesis Completion Status

Completed

Subject

Biosciences

Language

English

Added

2021-02-17 19:49:13

Modified

2023-01-06 19:20:37

ARI ID

1676719692268

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ایک کار آمد تالیف

ایک کار آمد تالیف
ڈاکٹر قیصر آفتاب
جب میں نے یونیورسٹی آف سیالکوٹ میں بطور اسسٹنٹ پروفیسر شعبہ اردو میں جوائننگ کی تو اس وقت نعمت اللہ ارشد گھمن ایم فل اْردو کا مقالہ لکھ رہے تھے۔ میری موجودگی میں ہی ان کا زبانی امتحان ہوا جس میں یہ نا صرف کامیاب و کامران رہے بلکہ گولڈ میڈل کے بھی مستحق ٹھہرے۔ میں نے اس دورانیے میں یہ بات محسوس کی کہ موصوف نہ صرف اساتذہ کے ساتھ مودب رہے بلکہ اپنے ہم جماعتوں کے ساتھ بھی ان کا رویہ بہت دوستانہ رہا۔ ایم فل اردو کی سطح پر طلبہ و طالبات کو اپنے کورس ورک کی تکمیل کے لیے بہت سی مشکلات کا سامنا کرنا پڑتا ہے۔ لائبریریوں میں کتب کی قلت ہے اور پھر وہ اپنی ملازمتی مجبوریوں کی وجہ سے لاہور یا اسلام آباد کی لائبریریوں میں جانے سے بھی قاصر ہوتے ہیں۔ طلبہ و طالبات کی اس مشکل کو حل کرنے کے لیے شاگردرشید نعمت اللہ ارشد گھمن نے یہ بیڑا اٹھا یاہے اور ایم فل اردو کے پاکستان کی تقریباً تمام یونیورسٹیوں کے اہم موضوعات پر مشتمل کتاب لکھ ڈالی ہے۔ یہ کتاب نہ صرف طلبہ و طالبات بلکہ اساتذہ کے لیے بھی انتہائی کارآمد ثابت ہوگی۔ میرے خیال میں اس سے قبل اس موضوع پر ایم فل سطح کی کوئی کتاب موجود نہیں ہے اس لیے یہ اپنی نوعیت کا نیا تجربہ ہے۔ میری دعا ہے کہ اللہ تعالیٰ نعمت اللہ ارشد گھمن کو مزید کتب لکھنے کی توفیق عطا فرمائے اور انہیں زندگی کے ہر میدان میں کامیابی عطا فرمائے۔ آمین
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Problems and Challenges to English Language in Madaris of Pakistan

Language is a communication tool to impart education at every level that is why different languages are taught for this purpose. In Madaris of Pakistan, Arabic is commonly taught as it is the language of basic Islamic sources i.e. The Holy Quran and Hadith. This paper will basically try to understand the learning of English as a language is not given importance, although it is very essential nowadays but besides this, it faces many problems and challenges in religious Madaris of Pakistan. Many factors are involved in this situation. In modern world, English language specially can be very helpful to the purposes of these Madaris. Learning of English language will help to impart, propagate and defend the message of Islam on a larger and wider scale. One can use it for da’wah and calling others to Allah. But some elements of Madaris are not well informed about to this fact that they have not such a larger vision to understand and absorb the facts. On the other side, supporters of teaching English language in Madaris are unluckily blind to the positive, historic, reformative role of Madaris. This situation is creating misunderstandings and these bodies are seen opponents while they must be supporting to each other. This article reviews the challenges and the problem and challenges to English language in Madaris as well as how to bridge the chasm created between the two schools of thought.

Prevalence of Significant Liver Fibrosis in Patients With Hiv Monoinfection Compared to Those With Hiv-Hepatitis B Coinfection As Assessed by Shear Wave Elastography

Background: Liver disease is an emerging management problem in human immunodeficiency virus (HIV) infected patients. The incidence of chronic Hepatitis B infection, which accelerates the progression of chronic liver disease and development of liver fibrosis, is ten times higher in patients with HIV than the general population. Staging of liver fibrosis provides essential information in management of these patients. Objective: To determine the prevalence of significant liver fibrosis in patients with HIV mono-infection versus those with HIV-HBV co-infection as assessed with shear wave elastography (SWE). Methods: This was a cross-sectional study whereby HIV infected patients attending the HIV clinic at AKUH, N were consecutively recruited into the study. A total of 105 patients, 70 with HIV mono-infection and 35 with HIV-HBV co-infection, had liver elastography obtained using SWE to assess for presence of significant fibrosis the cut-off of which was 5.6 kPa. The prevalence of significant liver fibrosis was compared between the two groups. Assessment of APRI score (a non-invasive serum biomarker of liver fibrosis) in these patients was also done. Results: The prevalence of advanced liver fibrosis was significantly higher (p <0.0001) in patients with HIV-HBV co-infection, 25.7%, compared to those with HIV mono-infection, 7.1%. APRI score was higher in patients with HIV-HBV co-infection than those with HIV mono-infection. Discussion: The prevalence of significant liver fibrosis observed in the two proportions in the current study is comparable to those reported in other studies. HIV co-infection with HBV accelerates progression to significant liver fibrosis. Association of low CD 4 count with advanced fibrosis supports earlier starting of antiretroviral therapy to prevent rapid progression of liver disease in HIV positive patients. Higher APRI scores in the HIV-HBV co-infected group was as a result of higher AST levels. Conclusion/recommendations: In view of the high prevalence of liver fibrosis in patients with HIV-HBV co-infection, regular monitoring of the disease progression is recommended. A study involving follow up of HIV-HBV co-infected patients to assess for effects of therapy is also recommended.