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Molecular Docking Protocol Optimization for Aurora Kinase a and B Inhibitors

Thesis Info

Author

Natasha Mahmood

Supervisor

Muhammad Muddassar

Department

Department of Biosciences

Program

BSB

Institute

COMSATS University Islamabad

Institute Type

Public

City

Islamabad

Province

Islamabad

Country

Pakistan

Thesis Completing Year

2015

Thesis Completion Status

Completed

Subject

Biosciences

Language

English

Added

2021-02-17 19:49:13

Modified

2023-01-06 19:20:37

ARI ID

1676719729724

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کر کے قول قرار دے بھج جانا

کر کے قول قرار دے بھج جانا
چنگا نہیں ہوندا لا کے پج جانا
ہک وار تاں یار ملا ربا
اساں ویکھدیاں سار ای رج جانا
پردہ رکھیے کسے دا رب آکھے
کم مرد دا اے پردہ کج جانا
دکھی دل نوں جنھاں نے جت لیا
کر سمجھ لے اوہناں نیں حج جانا
کم شہر دے وچ نہیں کوئی اے پر
گلی سجناں دی کسے پج جانا
اوکھے ویلے جو یار نہ کم آوے
چنگا ہوندا اے اوس توں بھج جانا

التربية الإسلامية وميادينها في ضوء الآية من سورة الجمعة

Islam is a religion of humanity; it takes much care of people and worries a lot about both the spiritual and the materialistic aspect of life. That’s way it gives a clear and solid code of life which don’t leave blank any single aspect of human life. Spiritual training and education is a major part of Islamic teachings, Islamic training goes side by side the Islamic education as both tied strongly to each other’s and there is no option to disconnect the Islamic education from the Islamic training and practice. Islam stresses on both the education and the training aspects at a time and don’t believe in dualism at all in Muslim society about Islam and its teachings, one who does not practices what he learns in training is much worse than one who don’t practices due to his ignorance. This verse of S┴ra Jum’ ā describes the importance of Islamic Training in a very clear way as this verse declares the Islamic training as a basic reason of sending the Prophet PBUH to the humanity.

Microbial Acc-Deaminase May Improve the Efficiency of Rhizobium Inoculation in Mung Bean under Salt Affected Conditions

High ethylene concentration under different environmental stresses such as salinity is one of the contributing factors for premature senescence of different plant parts. Plants under salinity stress produce increased levels of ethylene which inhibit the plant growth. Microbial 1-aminocyclopropane-1-carboxylic acid (ACC)-deaminase is the enzyme which is present in some strains of plant growth promoting rhizobacteria (PGPR). These PGPR alone and also in combination with rhizobial strains promote plant growth by lowering the endogenous level of ethylene along with some other mechanisms. A number of rhizobacterial and Rhizobium strains were isolated from rhizosphere and nodules of mung bean, respectively. The rhizobacterial strains were screened on the basis of ACC metabolism assay. The selected rhizobacterial strains containing ACC-deaminase activity and Rhizobium were assessed for their ability to tolerate salt stress by conducting osmoadaptation assay. These strains were further screened for their ability to promote growth of mung bean seedlings under salt-stressed axenic conditions in growth pouch/jar trials. Three most effective strains of PGPR (Mk1, Pseudomonas syrigae; Mk20, Pseudomonas fluorescens and Mk25, Pseudomonas fluorescens Biotype G), and Rhizobium phaseoli (M1, M6 and M9) were screened in co-inoculation for their growth promoting activity at original, 4 and 6 dS m-1 under axenic conditions. Strains from three most effective combinations were tested alone and in combinations in pot and field trials for their potential to improve growth, nodulation and yield of mung bean under salt- affected conditions. Results showed that salinity stress significantly reduced plant growth, some physiological parameters, nodulation and yield but inoculation with PGPR containing ACC-deaminase and rhizobia improved these, thus reducing the inhibitory effect of salinity. However, their combined application was more effective under salinity and the co-inoculation with PGPR strain Pseudomonas fluorescens and Rhizobium phaseoli was the most efficient for improving growth, nodulation, physiology and yield of mung bean. The effect of high ethylene concentrations on plant growth and performance of these strains for reducing this negative impact was also evaluated by conducting classical triple-response bioassay. Intensity of the classical triple response decreased due to inoculation with these strains as the root/shoot length of inoculated mung bean seedlings increased while stem diameter decreased which is typical indication of the dilution in classical triple response. Such bacteria could be very effective as co- inoculants to improve growth, physiology, nodulation and yield of mung bean under salt affected conditions. However, the degree to which these inoculants impart benefits to plant growth can vary with the conditions and PGPR strains. A PGPR strain with multiple traits could be more useful under diverse conditions compared to a strain containing single trait.