فلسطینی مستضعفین کی عصری صورتحال ایک جائزہ

The Muslims of today are overwhelmed and subjugated all over the world due to the bad intensions of colonizers. They are now called the oppressed people in the world. Especially the Muslims of Palestine are the main target of these colonialists, as Palestine is the controversial issue between the Muslims, Christians and Jews. It is the holy and sacred place for all of them. The Jews consider this place as their birthright and also due to their political and social self-interests they always tried to get their hold there by the oppression of Palestinian Muslims. The illegal Israeli (jews) state in Jerusalem is constantly oppressing the Muslims of Palestine. Due to this oppression these Palestinian Muslims are also called the oppressed people in the world. Today this problem of oppression in Palestine is more surpassing. Israeli (jews) people are persistently killing and forcing the muslims to leave this country. Palestinians are now immigrants and seekinf refuge from different countries but unhappily they are also in trouble and in pathetic condition. They are just helpless and even deprived of their basic rights. Keeping in view this scenario, in this article a brief review is given about the history and the present situation of oppression on Palestinian Muslims

Formulation, Development and Cosmeceutical Evaluation of Creams on Human Skin Containing Natural Phenolics

Natural antioxidants acquired from natural plants seek considerable attention to cure various ailments including acne, melasma, itching, inflammation, dry skin, atopic dermatitis and aging because synthetic agents have numerous side effects. The current study was aimed to fabricate and stabilize the novel carrier system in the form of topical water-in-oil emulsions (creams); encapsulated with natural extracts of Ananas comosus (F1), Amomum subulatum(F2) andSyzygium cumini (F3) having comparable antioxidant activities, their in-vitrocharacterization and in-vivo evaluation on human volunteers.The extracts of Ananas comosus, Amomum subulatum and Syzygium cuminiwere effectively prepared and investigated for their biological activities. The antioxidant activities of all the extracts were analyzed using1,1-diphenyl-2-picryl-hydrazyl (DPPH) free radical method while ascorbic acid was used as a standard antioxidant. The total phenolic contents were determined in all fruit extracts using Folin-Ciocalteu’s (FC) method.Antibacterial activities of all extracts were estimated by measuring zones of inhibition against two species of gram positive bacteria and three species of gram negative bacteria using agar well diffusion method. Stable water-in-oilemulsions (creams); F1, F2, F3were formulated using different concentrations of paraffin oil, water and non-ionic emulsifying agent i.e. polysiloxane polyalkyl polyether copolymer (Abil ® EM 90) versus respective bases B1, B2, B3 (without fruit extracts).In-vitro characterization of the formed emulsions F1, F2, F3 and their respective bases B1, B2, B3 were based on to assess the changes on physical stability parameters (color, liquefaction, centrifugation,viscosity and rheological parameters)when stored at different temperatures i.e. 8°C, 25°C, 40°C, 40°C ± 75% RH and 50°C and time intervals for a period of 90 days as per stability study guidelines. In-vivo evaluation was based on to scrutinize the effects of formulationsF1, F2, F3 and respective bases B1, B2, B3 on various skin parameters including skin irritancy, melasma, sebum contents, moisture contents, transepidermal water loss (TEWL) and skin elasticity on human male volunteers for a study period of 12 weeks using photometric device in a draught free room with modulated conditions of temperature (22-25 0 C) and humidity (55-60%). The study was single blinded, controlled, split face with 3-groups (F1, F2, F3) containing 11 volunteers each. Statistical tools of ANOVA test and paired sample t-test were used to evaluate the changes produced. The results of antioxidant activities of formulations F1, F2, F3 were 92.0%, 89.0% and 81.0% respectively. Selected formulations F1, F2, F3 as well as respective bases B1, B2,xxiii B3remained stable at all storage conditionswith respect to color, liquefaction, centrifugation,viscosity and rheology as desired for 12 weeksin vitro study period.All the samples manifested shear thinning behavior with increasing shear rate indicating pseudoplastic flow of the formed emulsions. It was evident from the results of in-vivo studies that no primary skin irritancy was observed with patch test. Besides that, statistical interpretation indicatedthat treatment with formulations F1, F2, F3 was superior as compare to respective bases B1, B2, B3 because it significantly (p≤0.05) reduced the skin irritancy,melasma, sebum and TEWL contents throughout the study period while significantly (p≤0.05) improves the epidermal hydration level and skin elasticity at the end of study period compares to baseline value. Conclusively, formulations F1, F2 and F3 encapsulated with natural antioxidants exhibit better physicochemical stability at all storage conditions and was well tolerated by all volunteers and suitable to treat contact dermatitis, greasy skin, acne, seborrheic dermatitis and augmenting beauty and attraction by depigmentation of human skin and represent a propitious improvement in skin barrier function and used as a functional moisturizing and anti-aging ingredient in topical skincare products. So, in future there is need to clinically evaluate these formulations in patients with compromised skin functions i.e. contact dermatitis, melasma, acne vulgaris and atopic dermatitis in order to explore the actual potential of these fruits.