حکیم حبیب الرحمن مرحوم ڈھاکہ
ڈھاکہ کے متعدد دوستوں کے خطوط سے یہ معلوم کرکے بڑا افسوس ہوا کہ بنگال کے جادو نگار ادیب اور نادرۂ روزگار طبیب شفاء الملک حکیم حبیب الرحمن نے یکم ربیع الثانی ۱۳۶۶ھ کی شب میں ضغطہ دم (بلڈ پریشر) کی بیماری میں سنہ قمری سے اڑسٹھ اور شمسی سے چھیاسٹھ برس کی عمر میں دفعتہ وفات پائی، مولانا ظفر احمد صاحب عثمانی تھانوی اپنے والا نامہ میں لکھتے ہیں:
’’آپ کو وفیات لکھنے میں ملکہ ہے ایک اور وفات نامہ معارف میں لکھ دیجیے، آپ کے اور میرے مخلص دوست حکیم حبیب الرحمن صاحب کا یکم ربیع الثانی ۱۳۶۶ھ مطابق ۲۳؍ فروری ۱۹۴۷ء کی شب میں دفعتہ بلڈ پریشر بڑھ جانے سے انتقال ہوگیا، اناﷲ۔
مرحوم حضرت حکیم الامت تھانویؒ کے ابتدائی صرف ونحو کے شاگرد اور بڑے عاشق تھے، علامہ شبلی کے دوستوں میں تھے، مسلم لیگ کی جب بنیاد ۱۹۰۶ء میں ڈھاکہ میں رکھی گئی اور نواب سر سلیم اﷲ خان اس کے صدر ہوئے تو مرحوم جوائنٹ سکریڑی ہوئے تھے، علم طب حکیم عبدالمجید خان صاحب سے حاصل کیا، اور اس میں کمال کا درجہ پایا، بنگال میں اس وقت ان کے درجہ کا کوئی طبیب نہیں سنا گیا، ڈھاکہ میں طبیہ کالج قائم کیا، اور بڑی ہمت سے اس کو چلانے سے گورنمنٹ نے شفاء الملک کا خطاب دیا، جس کو ( لیگ کی تحریک کی بنا پر) ستمبر میں واپس کردیا‘‘۔
ان کے اس کالج سے بہت سے اطبا پیدا ہوئے اور اب بھی سلسلہ درس جاری ہے اور خدا کرے برابر جاری رہے۔
مولانا شبلی مرحوم مسلم ایجوکیشنل کانفرنس کے سالانہ اجلاس کے سلسلہ میں ۱۹۰۶ء میں ڈھاکہ تشریف لے گئے تھے، وہاں سے دو دوستوں کے نام ہم لوگوں کے لیے تحفہ میں اپنے ساتھ لائے، ایک کا نام مرزا فقیر محمد صاحب...
Background of the Study: To assess the functional outcome among patients with arthroscopic ACL reconstruction with endo-button at Ghurki Trust Teaching Hospital post 6 months.
Methodology: A single centered survey was conducted on 67 patients with arthroscopic AC Ligament reconstruction using Hamstring auto-graft (Semitendinosus-Gracilis tendons) after 6 months and evaluated for functional outcome. The data was collected from Ghurki Trust Teaching Hospital. The sampling procedure utilized was non-probability sampling. Functional outcome was assessed using subjective form of IKDC score. Data was analyzed using SPSS version 23.
Results: Out of 67 patients, all were male. The pre-operative subjective IKDC scoring was less than 30 and post-operative mean IKDC scoring is 73.92. On the basis of findings of study, significant improvement was observed after ACL reconstruction post 6 months.
Conclusion: ACL reconstruction shows significant improvement in knee function and significant recovery of preoperative functional status.
The present study was conducted to investigate the pharmaceutical potential of wild and commercial gums. After the process of purification, Dalbergia sissoo and Acacia modesta were selected for the present research among the eight initially selected gums. For the use of gum as binder in tablet the physiochemical characteristics such as pH, fluorescence analysis, swelling index and rheological studies were determined. Both selected gums were acidic in nature. D. sissoo and A. modesta showed light brown and creamy color in fluorescent analysis, respectively. The viscosity measurements were made by the rheological analysis and D. sissoo and A. modesta provide different rheological pattern. The aqueous solution of crude A. modesta was more viscous than D. sissoo. Carbohydrates were present in high concentrations determined through proximate and biochemical analysis. The elemental profiles of crude gums were studied by the laser induced breakdown spectroscopy (LIBS) and significant number of elements was recorded. Crude gums exhibited a number of drawbacks in their application that can be overcome by hydrolyzed and modified to improve the functional properties of biopolymers. The selected gum were hydrolyzed (acidic, basic and enzymatic) and modified (polyacrylamide grafting and carboxymethylation).The antioxidant activities of crude, hydrolyzed and modified gums were determined and the selected samples exhibited significant antioxidant potential. The antimicrobial, toxicological studies viz. antimutagenic and hemolytic analyses were performed. All the tested gums samples exhibit good antibacterial activity. All samples were found non-mutagenic to Salmonella typhimurium TA 98 and TA 100, and did not show significant hemolytic activity. The structural characterization was carried out by scanning electron microscope, 12 thermogravimetric analysis, differential scanning colorimetry, Fourier transform infrared spectroscopy, X-ray diffraction. The change in viscosity after hydrolysis and modification was analyzed by performing the flow test. There was a decrease in viscosity of crude gum after hydrolysis and modification. Gum based silver-nanoparticles were prepared on the basis of green chemistry principle and possess important microbial applications. Nanoparticles prepared by using both gum showed synergistic high antibacterial activity. The potential of D. sissoo and A. modesta to be used as tablet binder was determined. Bulk and tapped density, hausner’s ratio and carr’s index of the prepared granules were studied. After the formation of tablets, the weight uniformity, hardness, friability, disintegration time and drug release were determined. Hydroxypropyl Methycellulose (HPMC) is used as standard binder. The prepared tablets using gums showed faster and slower dissolution profiles in the same dissolution system. The crude gums have the highest dissolution rate. While the dissolution rate was decreased in the case of modified and hydrolyzed gum samples. The crude gums showing slower release can be useful in sustained release tablets as release controlling polymer / viscoslysing agent. And the hydrolyzed and modified gums having faster release rate are helpful in conventional tablet formulation. The current research comprehensively explored the selected gums for their application as biobinder as well as matrix for nanoparticles studies. In future, these results of selected gum may be used in pharmaceutical field on the pilot or industrial scale as biobinder and other applications like prebiotic for probiotics and green material for nanoscience etc.