علاقة التربية بالتعليم والأسوة الحسنة

The bond of education and character education is like that of body and soul. In the comprehensive process of Islamic character building, education is an integral part. Character is the provision for life journey where as education is the light on the path. The recognition of distinct objectives of education and trenchant targets of character education is necessary to solve the crisis of character faced by contemporary world. Education is a lightening experience to develop the skills and awareness whereas character education helps the individual to be sincere with himself, obedient to his Lord, and compliant with the moral values which is the outcome of character education. The curricula of education, no matter how powerful and evolved may it be, need to be translated into behavior. Therefore, a role model is needed to achieve educational goals. The work of the prophet was characterized with deep insight, strong determination, firmness, honesty. These virtuous qualities caused to enlighten hearts with the right faith. Character cannot be built thorough ease and quiet, it is a process built upon a philosophy and laws, which springs from the moral values followed by the society. Islamic character education evolved from the infallible sources of Islamic Sharia: The Qur’an and Sunnah of the beloved Prophet Muhammad (S. A. W) who formed the characters of his noble companions (R. A) in best manner and equipped their generation with everything they needed to lead a successful life in this world and in hereafter. This paper elucidates the connection between education and character education, and sheds light upon the importance of role model in bringing the change as well as covers the major restraints that shackle the process of education and character education.

Computational Analysis of Metabolic Pathways and Protien-Protien Interactions Ppls of Clinically Significant Pathogens, and Identification of Inhibitors of Ppls

Salmonella enterica is a Gram-negative facultative anaerobic bacteria. It belongs to the family of Enterobacteriaceae. Infections caused by Salmonella species are major threat to the human and animal health. After 1-3 days of ingestion of contaminated food, the patient develops diarrhea, fever, vomiting, and abdominal cramps. The situation is exacerbated if not treated promptly. Whole genome sequencing projects of clinically significant serovars of S. enterica have opened new perspectives of medical research. Using the genomic data, novel approaches are being employed throughout the world to find new protein targets for drug designing and screening. Targeting the essential metabolic pathways of the bacteria is the approach which we have focused in our study. The protein sequence and metabolic pathway data of the core proteome of S. enterica was analyzed in comparison to that of Homo sapiens. Various computational tools (BLASTp, CD-HIT, and Shell scripting) and datasets (NCBI, DEG, and KEGG) were extensively utilized to find non-homologous and essential enzymes of the pathogen. We discovered 73 enzymes belonging to metabolic pathways found only in the bacteria but not in H. sapiens, and proposed them as potential drug targets. Later, we selected an essential outer membrane protein complex (LptD/E) of S. enterica involved in lipopolysaccharide assembly, as a target in search of an inhibitor of the PPI complex. Druggable sites at the interface of PPI were identified by PocketQuery followed by virtual screening of the ZINC database of commercially available compounds using the ZINCPharmer tool. Energy minimization and scoring of short-listed compounds was performed using SMINA. A rational screening of >10,000 compounds resulted in 3 compounds depicting favorable polar interactions and optimal conformation for binding with the LptD protein. We propose that this interaction may lead to block the LptD interaction with LptE and lipid molecules and in result may block the LPS assembly.