خان بہادر شیخ محمد جان
افسوس ہے گزشتہ مہینے خان بہادر شیخ محمد جان صاحب کاکم وبیش ۸۵برس کی عمر میں کلکتہ میں انتقال ہوگیا اوروہیں تدفین عمل میں آئی۔ مرحوم قومی اعتبار سے ہندوستان کے ان پنجابی مسلمانوں میں سے تھے جو تجارت اور کاروبار میں ترقی کے لیے ممتاز ونمایاں ہیں۔ مرحوم اپنی جماعت میں بھی ممتاز اورنہایت محترم و معزز سمجھے جاتے تھے۔ طبعاً نہایت مخیر اورغربا و فقراء کی انفرادی طورپر امداد کرنے کے علاوہ قومی،مذہبی اورملکی معاملات میں بڑی فیاضی اورکشادہ دلی سے خرچ کرتے تھے۔ ان کومسلمانوں کے تعلیمی مسائل سے بڑی دلچسپی تھی، چنانچہ ان کا قائم کیا ہواخان بہادر شیخ محمد جان ہائر سکینڈری اسکول کلکتہ کی ایک قدیم اورنیک نام مسلمان بچوں کی تعلیم گاہ ہے۔ علاوہ ازیں وہ کلکتہ اوربیرون کلکتہ کے بیسوں بلندپایۂ اورممتاز تعلیمی اداروں کے رکن تھے۔ دیوبند کے علماء سے ان کو بڑی عقیدت اورارادت تھی۔ عقیدے اور عمل اوراخلاق وعادات کے اعتبار سے اعلیٰ درجہ کے مسلمان تھے، پنجگانہ نمازباجماعت کی پابندی کے علاوہ تہجد گذار بھی تھے اور اوراد و ظائف کاشغل بھی رکھتے تھے۔حضرت مولانا سید حسین احمد مدنی سے بیعت تھے۔ سیاسی اعتبار سے کٹر نیشلسٹ تھے، کانگریس اور جمعیۃ العلماء کے ہم خیال اور فرقہ وارارنہ سیاست کے ہمیشہ مخالف رہے اور اگرچہ تقسیم سے پہلے مسلم لیگ کی تحریک کے سخت بحران وجوش کے باعث دوسرے مسلم نیشنلسٹ اکابر طرح خان بہادر صاحب کوشدید اذیتوں اورتکلیفوں کاسامنا کرنا پڑا، تاہم انھوں نے یہ سب کچھ برداشت کیا اوران کے خیال اورروش میں کوئی تبدیلی پیدانہیں ہوئی۔ ارکان ندوۃ المصنفین کے ساتھ ذاتی تعلق کے علاوہ شروع سے ادارہ کے محسن رہے، تقسیم کے وقت جب ادارہ لٹ لٹا کرتباہ وبرباد ہوگیا، ارکان ادارہ بے خانماں اوربے سروسامان ہوگئے تھے اورادارہ کے دوبارہ قائم اورجاری رہنے کی بہ...
The purpose of this study is to determine the development of MSMEs in Gorontalo Regency and to provide new innovations in the development of MSMEs based on Creative Economy (Ekraf) and Gig economy in Gorontalo Regency. This study uses a descriptive qualitative approach, which describes and describes facts according to the phenomenon of how development is seen from the strengths, weaknesses, threats and opportunities (SWOT analysis) with the aim of providing an Creative Economy-based MSME development strategy and the Gig economy in Gorontalo Regency. Data collection was carried out through observation, interviews and documentation about the strengths, weaknesses, opportunities, and threats of MSMEs against informants from three business fields, namely the Food Business Sector (dodol processed food), clothing (Sulaman Karawo) and handicrafts spread across three existing sub-districts in Gorontalo Regency. The results showed that the creative economy-based and gig economy-based MSMEs in Gorontalo Regency have not been fully implemented by MSME actors because they have limited capabilities and experience problems in their business development, this is due to several problems faced such as limited capital, raw materials and the use of simple production equipment, limited marketing media due to the absence of a MSME center, the types of products offered, quite a lot of transaction costs, less skilled labor, and product copyright registration problems for that from the results of the SWOT analysis of the diversification strategy at a more precise value to be applied, because it is considered more appropriate to the current conditions in Gorontalo Regency. In addition, the use of the gig economy is a part-time worker who is competent and innovative for MSMEs that are progressing and ready to compete.
Cutaneous leishmaniasis remains one of the most important neglected tropical diseases. It is prevalent in Pakistan where its presence has been reported from all provinces. Apart from Leishmania species and Phlebotomus sandfly vector, host genetic factors also influence the severity and outcome of infection. This study explored 2 host genetic elements (SLC11A1 and CCR5) to assess their role in cutaneous leishmaniasis. SLC11A1 codes for the solute carrier transmembrane protein that is directly involved in the restriction of Leishmania parasites within macrophages. Genetic association studies of SLC11A1 suggest its role in predisposition to leishmaniasis. However, recent reports fail to support this association. CCR5 is translated into CC chemokine receptor 5 that seems to play a dual role during leishmaniasis. It helps the parasites to persist within the host, extending the infection, while at the same time assists HIV entry into immune cells. This leads to Leishmania/HIV-coinfection, a complexity that seems to have risen in the last decade or so. The current study analyzed a total of 393 individuals including 274 cutaneous leishmaniasis cases and 119 uninfected controls exposed to the same environment. Results reveal a higher incidence of infection among males (70%), possibly due to a higher exposure to the sandfly while the most affected age group were children 15 years or younger. Single loci and haplotype analysis of 8 genetic variations of SLC11A1 revealed no association with susceptibility to cutaneous leishmaniasis. These results hold importance because they question the significance of SLC11A1 as a candidate susceptibility gene particularly in this region since other Asian countries have reported similar results. No significant association was observed for the HIV-protective CCR5Δ32 allele and leishmaniasis as well. This low frequency of Δ32 allele exposes the population to a higher risk of HIV and hence co-infection. Incidentally, the prevalent wildtype CCR5 reinforces its supportive role in disease progression. However, five Δ32 homozygotes were identified which have not yet been reported from Pakistan. The geographical distribution of Δ32 allele was significantly higher in Khyber Pakhtunkhwa province as compared to the rest of the country. Hence, this study presents new insights and understandings into cutaneous leishmaniasis at the genetic level.