نسب نامہ
اعتراض نمبر۶
مارگولیس کے درپردہ دوسرا اعتراض کہ آنحضرت ﷺ آل اسمٰعیل ؑسے نہیں تھے ‘ کے بارے اعلانیہ سر ولیم میور نے کہہ دیا کہ ’’ یہ خواہش کہ مذہب اسلام کے پیغمبر ﷺ کو حضرت اسمعیل ( علیہ السلام) کی اولاد سے خیال کیا جائے اور غالباََ یہ خواہش کہ وہ نسل اسمٰعیل سے ثابت کیے جائیں ‘ ان کی حین حیا ت میں پیدا ہوئی تھی o اور اس طرح محمد ﷺ کے ابراہیمی نسل کے نسب نامہ کے ابتدائی سلسلیگھڑے گئے ہیں o اور اسمعیل ؑ اور بنی اسمعیل کے بے شمار قصے نصف یہودی نصف عربی سانچہ میں ڈھالے گئے ہیں‘‘ o ( ضیاالنبی ۔۷۔۱۷۱)
جواب : ارشاد خدا وندی ہے رَبَّناَ وَابْعَثْ فِیْھِمْ رَسُوْلاََ مِّنْھُمْ یَتْلُوْا عَلَیْھِمْ اٰیٰتِکَ وَیُعَلِّمُھُمْ الْکِتٰبَ وَالْحِکْمَۃَ وَیُزکِّیْھِمْ ط( البقرہ ۱۲۹،پارہ۱) ’’ترجمہ : اے ہمارے رب ان میں ایک برگزیدہ رسول انہیں میں سے بھیج تاکہ پڑ ھ کر سنائے انہیں تیری آیتیں اور سکھائے انہیں یہ کتاب اور دانائی اور پاک صاف کر دے انہیں ‘‘۔ خانہ کعبہ کی بنیادیں اٹھاتے وقت باپ بیٹے ( ابراہیم ؑو اسمعیلؑ ) دونوں نے اپنی اولاد کے لیے دعا مانگنے کے بعد ایک رسول کی بعثت کے لیے التجا کی َ۔ دیکھنا یہ کہ اس دعا کا مصداق کون ہے ۔ ’’ وا بعث فیھم رسولا منھم ‘ پر غور کرنے سے معلوم ہوتا ہے کہ ’’ ھم ‘‘ کی ضمیر کا مرجع امت مسلمہ ہے یا ذریتنا ہے ۔ ھم کی ضمیر کا مرجع کسی تاویل سے اور قرار نہیں دیا جا سکتا ‘ اب ان دو صورتوں میں پہلی صورت یہ ہے کہ امت مسلمہ میں سے جو ہماری اولاد سے ہو ‘ رسول مبعوث فرما ۔ دوسری صورت میں یہ معنی ہو گا کہ ہماری اولاد میں سے ایک رسول بھیج ۔...
The deeds and actions of the Holy Prophet ﷺ is a practical interpretation of the Holy Qur'an. Allah Almighty has stated his Shari'ah in short but comprehensive words that “take what the Holy Prophet ﷺ has given you and which you forbid”. Therefore, his command is the command of Allah Almighty and not yours. That is why the Holy Qur'an has declared his obedience to be the obedience of Allah Almighty. And from the instructions of the selected scholars of the ummah, it is clear that the legislative status of The Sirah is authenticated. Allah Almighty has given him a special position of Shariah.
As for the legislative status of Sira-e-Taiba, both the special and the general legislation are specific or special to him. Special legislation etc i.e. you have legislated for a specific person at certain times like accepting the condition of a person that he will convert to Islam if he prays only two prayers. The other person cannot join. The general legislation in which you have enacted all kinds of legislation for the common ummah is included. The center and axis of Islamic law is your caste. You have complete control over the status and sanctity, likes and dislikes as you like, for whom you can make Shariah whenever you want. It is as if you are a follower of the Shari'ah. He also has full authority in the brief description of the Qur'an, in the adherence to the Absolute, and the explanation of similarities. You are authorized to legislate as a Shari'ah and Shari'ah in all areas of worship, affairs, debates, and crimes.
Therefore, in this article, the legislative status of His Sira-e-Taiba has been explained in the light of Qur'an and Hadith, Sahabah and Tabi'een, and the commandments of Imams and jurists.
Hepatocellular Carcinoma is 6th most predominantly existing cancer and second largest contributor to human mortality all over the world. This study is focused on identification of ―Potent Anticancer terpenes‖ from selected experimental plants that may be successfully practicized in cancer chemotherapeutic mainstream. Twenty five plants were taken under consideration for present piece of work. Ethanolic extracts of different parts of these plants were prepared. Standard analytical methods including UV-VIS Spectroscopy, FTIR and GCMS effectively confirmed presence of a large number of secondary metabolites i.e. Flavonoids, Phenols, Terpenoids, Quinine, Saponins and Alkaloids in these extracts. Quenching potential of ethanolic extracts against DPPH free radical fabricated possible antioxidant dynamics of selected experimental plants. During present work we focused on the role of identified plant ―Terpenoids‖ involved in Hepatocurative as well as Hepatoprotective activities. The ethanolic extracts and these identified effective anticancer ―terpenes‖ were used for further experimentation on Hepatocellular Carcinoma in O. cuniculus. In vitro cytotoxic effects of ethanolic extracts of experimental plants and identified ―terpenes‖ (Hexadecanoic acid, methyl ester, Methyl decanoate, n- Hexadecanoic acid ) were assessed by MTT (3-[4, 5-dimethylthiazole-2-yl]-2, 5-diphenyl-tetrazolium bromide) assay against Mouse Fibroblasts (3T3) cell lines along with their IC50 calculation. Hepatocellular Carcinoma was induced by CCl4 administration in O. cuniculus. The safe doses of CCl4, ethanolic extracts and identified ―terpenes‖ were also optimized during this piece of work. Hepatocurative and Hepatoprotective potentials of plants extracts and their identified ―terpenes‖ along with standard drugs (in medical use for treatment of Hepatocellular Carcinoma) were effectively analysed by monitoring physiological changes (pH of saliva, temperature, blood glucose, body weight) in induced Hepatic Carcinomic O. cuniculus. Furthermore, Hematological investigations (Hb, RBC, TLC, MCV, MCH, MCHC and Platelets), changes in Liver Biochemical Enzymes (Alkaline phosphatase, Aspartate amino Transferase and Alanine aminotransferase) and Hepatic Carcinoma Marker (Alpha Fetoprotein) efficiently marked Therapeutic as well as Prophylactic outcomes followed by Histo-Pathological studies of Carcinomic and healthy livers following Hematoxylin and Eosin Staining. xxiii The research work was aimed to critically examine potential role of naturally occurring ―Terpenoids‖ from diverse botanical origins for chemoprevention as well as chemotherapy of liver tumors. Both in vitro and in vivo effects were noted and recorded. We successfully identified the anticancer ―terpenes‖ giving better and non-toxic results against Hepatocellular Carcinoma in comparison to synthetic anti-cancerous drugs in market. In addition to this, we also recorded similar anticancerous response of ethanolic extracts of selected experimental plants against induced Hepatocellular Carcinoma in O. cuniculus. The results of the present piece of work are promising and may be very helpful for finding green, cost effective and eco-friendly chemopreventive and chemotherapeutic measures to deal successfully with liver carcinomas.