الشيخ محمود بن بكر البخاري الكلاباذي: حياته وآثاره دراسة متخصّصة لكتابه ضوء السراج في علم الفرائض

Ashaykh Mahmūd bin Abī Bakr bin Abīulala bin Alī Al-bukhārī Al-kalābādhī is one of scholars of  Mirāth. He was born in 644 A.H. And died in 700 A.H. He was a man of eminence in Central Asia. He visited many metropolitan cities across the world to get knowledge. During his foreign visits, he contacted great scholars of Islamic sciences. Similarly, thousands of students used to attend his lectures. Allāmah Kalābādhī was a man of letters. He wrote many books. Famous of them are: Ḥall ul Frāi Fī Sharah Naẓm Assirājiyah, Ḍaw us Sirāj Fī Sharah Assirājiyah, Mushtabeh un Nasab Fī Asmā ur Rijāl, Mujamush Shuyūkh, Al Minhāj Al Muntakhab.

Synthesis of Novel Heterocyclic Compounds

The present dissertation entitled “Synthesis of Novel Heterocyclic Compounds” is comprised of two parts. Part A describes the synthesis of Azaborines. In Part A the synthesis of Azaborines is classified into two classes. (a) 1, 3, 2 benzodiazaborininones (carbonyl containing, boron-based heterocyclic scaffolds) (68-89). In the synthesis of 1, 3, 2 benzodiazaborininones, anthranilamide reacted with different commonly available potassium organitriflouroborates using a fluorophile (BF3NH2Et) with efficient methodology. NH B NH O 68 F NH B NH O MeO OMe 69 NH B NH O O 70 NH B NH O 71 NH B NH O Br 72 NH B NH O F F 73 NH B NH O COOMe 74 NH B NH O CN 75 NH B NH O 76 NH B NH O O 77 NH B N H O CH3 78 Abstract ix NH B N H O CF3 79 NH B N H O S 80 NH B NH O NO2 81 NH B NH O 82 NH B NH O 83 84 NH B NH NH2 O NH B NH Cl O 85 NH B NH O CO2Me 86 CH2CO2Me NH B NH O 87 NH B NH O 88 N H B NH N O 89 The second class of azaborines prepared were 1,2-dihydroazaborinines, including 1-benzenyl-2-quinolinyl/isoquinolinyl-1,2-dihydroazaborinines (91-95, b1). These were obtained by reacting N-benzyl-2-vinylaniline with potassium organotrifouroborates in the presence of SiCl4 and Et3N. 2-Ethynyl-1,2-dihydroazaborinines (96-97, b2) were synthesized by using the same methodology where 2-vinylaniline was used with different commercially available potassium organotriflouroborates. All the products synthesized were charecterzied by FT-IR, 1H-NMR, 13C-NMR, 11B-NMR, HRMS. The results obtained confirmed the formation of desired product. Abstract x B N N B N N B N N B N N B N N 91 92 93 94 95 B HN TMS B HN F 96 97 Part B. Part B consists of the synthesis of 2,4 di-substituted quinolines. The 2, 4- disubstituted quinolines were synthesized using a Povarov related reaction using indium chloride as a catalyst. Two classes of 2,4 di-substituted quinolines were prepared. (c) Quinoline isoindolindiones (187-193) products were synthesized in two steps.The First step involved Schiff base synthesis while second step involved condensation of Schiff bases with N-propargylphthalimide. N Cl OMe N O O N Br OMe N O O N OMe N O O MeO 187 188 189 Abstract xi N OMe N O O N OMe N O O N Cl N O O MeO N N O O 190 191 192 193 Second class is (d) benzoquinoline isoindolindiones (194,195). These compounds were prepared by reacting aldehydes, 1-naphthyl amine with N-propargylphthalimide in presence of indium chloride catalyst. All these compounds were characterized through FT-IR, 1H-NMR and 13C-NMR. Along with N-propargylphthalimide, another alkyne, 1- nitro-4-(prop-2-ynyloxy)benzene was used under the same conditions. A reaction was attempted where 1-nitro-4-(prop-2-ynyloxy)benzene was reacted with benzo[c][1,2,5]thiadiazol-5-amine and different aldehydes, but the product isolated was not the desired one. N N O O N N O O 194 195