حسن نگر کے سارے پنچھی مر جائیں گے
عکس تمھارے حشر بپا سا کر جائیں گے
ہجر وصال کے جھگڑوں سے ہم دور بہت ہیں
رقص جنوں کی رسم تو پوری کر جائیں گے
تجھ پر مرنے والوں کی تو بات ہی کیا ہے
مرتے مرتے آخر اک دن مر جائیں گے
تیری تان پہ جھومیں گے یہ سب دیوانے
اور نچھاور اپنا سب کچھ کر جائیں گے
قیس میاں کے قصے بھی ہم جانتے ہیں سب
تم سمجھے ہم عشق میں شاید ڈر جائیں گے
پاگل لڑکی شعر جنوں کا قصہ ہے سن!
کون سنے گا جب کردار مکر جائیں گے
Assessment and the learning process become two intertwined concepts that are impossible to separate. When compared to the other three abilities, reading skills are the most important in English learning. In order to meet the demands of modern teaching development, information and communication technology is required for English language instruction and assessment. The purpose of this study is to examine the requirements of both learners and pursuers in terms of the use of information and communication technology in reading instruction assessment (Reading Assessment). This current study used two data collection technique, namely questionnaires and interviews analyzed quantitatively and qualitatively. Respondents in this study were selected by purposive sampling involving 70 students and 5 teachers in vocational schools. The results of this study found that (1) The students’ goal and necessities differ, (2) The students are at beginner level at reading skill and have reading word and sentences fluently and correctly, (3) They want familiar contents based on their life, environment and major, (4) The need of information and communication technology both for learning and assessing and (5) Through the product, the English learners would be learning, collaborative and independent. The researcher advised for further researcher to conduct the development the information and communication technology for teaching and assessing English learners in vocational schools.
This dissertation describes the syntheses of indole and tryptamine derivatives via various synthetic strategies and screening of their biological activities. All synthetic compounds were characterized by different spectroscopic techniques such as 1H-, and 13C-NMR, EIMS/FAB-MS and EI-HRMS. This dissertation has been divided into three chapters and each chapter has its own numbering of compounds, figures, tables, schemes, and references. Chapter-1 comprises of the syntheses of Schiff bases of tryptamine 60-85 (Part A), urea and thiourea analogues of tryptamine 87-99 (Part B) and evaluation of their biological activities. Compound 78 (IC50 = 206.90 ± 0.88 μM) showed a potent activity against antiglycation activity, while, other thirteen compounds showed good to moderate activity. Chapter-2 describes the broad literature survey regarding the general introduction of indole, its biological importance and various synthetic schemes. It includes synthetic strategies of indole-3-acetamides 55-81 (Part A) and Knoevengal condensates of indole 83-118 (Part B) and evaluation of their biological activities. Eight compounds 84, 85, 88, 94, 106, 111, 115, and 118 were found to be weakly active against antiepileptic activity. Compound 83 (IC50 = 4.03 ± 0.05 μM) and 91 (IC50 = 4.89 ± 0.05 μM) were found to be the most active members of the series. Chapter-3 deals with the syntheses of bis(indolyl)methanes derivatives 38-92. The synthesized analogues were subjected for the random screening and were found to be active against anticancer and anti-inflammatory activities. Five analogues 64 (IC50 = 2.7 ± 0.1 μM), 47 (IC50 = 5.4 ± 0.8 μM), 52 (IC50 = 6.7 ± 0.6 μM), 78 (IC50 = 7.1 ± 1.3 μM), and 42 (IC50 = 7.2 ± 1.2 μM) were found to have potent activity as compared to standard ibuprofen (IC50 = 11.2 ± 1.9 μM), while compounds 45 (IC50 = 17.1 ± 0.2 μM) and 41 (IC50 = 26.6 ± 2.4 μM) possess weak antiinflammatory activity. However, seventeen compounds showed a weak anticancer activity.