گزشتہ عہد کی باقی ہیں جھلکیاں اب بھی
جلائی جاتی ہیں ساحل پہ کشتیاں اب بھی
دھواں دھواں ہے تصور کا آئنہ اب تک
سلگتی راکھ جلاتی ہے انگلیاں اب بھی
خراب حال سے اس گلستان دل کا میاں!
طواف کرنے کو آتی ہیں تتلیاں اب بھی
رواں دواں ہے ازل سے یہ کاروان زیست
سپاہ غم کی میں سنتا ہوں سسکیاں اب بھی
کواڑ بند ہوئے، مدتیں ہوئیں سانول°
پر اس کی یاد کی کھلتی ہیں کھڑکیاں اب بھی
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It is above-board that teachers play an important role in forming, formulating, molding and developing the society as individuals and as a whole. The youth has ever been an icon to lead the community in every sphere of life. The young stuff has played the pivotal role in preaching, scribing, teaching, political, economic and even diplomatic fields. The present research article explores the role of various companions of Holy Prophet (r) in these fields. Firstly, the Holy Prophet (r) groomed his companions, stormed their brains and paved them on the Divine way, then sent them to the said fields to work. Among those companions, Ḥaḍrat Muṣ‘ab bin ‘Umayr, Mu‘ādh bin Jabal, ‘Abdullāh ibn e Maktūm, Rāfi‘ bin Mālik, ‘Abdullāh ibn e Mas‘ūd, ‘Abdullāh ibn e ‘Abbās, Abū Sa‘īd Khudrī (y) as well as from females Ḥaḍrat ‘Āyshah, Ḥaḍrat Ḥafṣah, Shifā bint-e-‘Abdullah etc. Were appointed as preachers. Their task was not only to teach and educate the community rather to present themselves before them as paragon for their particular fields. The research concludes that the Prophet (r) laid down a criteria for selection of the teachers of Muslim Ummah. The selection criteria of the Prophet (r) was based not only on contingent variables but also on some special characteristics like teaching and training, potential empathy for the learners and a passion for social reformation. As a result, these preachers, after practicing their ideal and best performance, produced numerous educations, merchants, facilitators and reformers in the society. The present research paper will explore the companions’ efforts for the reformation of the society.
Neuropathic pain occurs due to a lesion or disease process affecting the somatosensory system. This pain is usually presented as an evoked response to non-painful stimuli (allodynia) and an exaggerated response to potentially painful stimuli (hyperalgesia). Despite rapid advancement of neuroscience and modern techniques related to drug design, effective drugs to mitigate the painful symptoms of neuropathy are still lacking. Systemic pharmacotherapy is currently regarded as the mainstay treatment and guidelines suggest offering a choice of gabapentin, pregabalin, amitriptyline, duloxetine, and tramadol. Unfortunately, the clinical effectiveness of these systemic agents can be limited by the extent of pain relief provided and the occurrence of significant side-effects. These limitations may be curtailed by investigating additional safe and effective agents and by localized therapy. In the present study, the flavonoid 6-methoxyflavone and a standardized extract of Bacopa monnieri (L.) Pennell (family: Scrophulariaceae), a widely reputed nootropic plant, were investigated via the systemic and topical routes for prospective neuropathic pain attenuating efficacy in the well-established rat models of chronic constriction injury of the sciatic nerve (CCI), cisplatin and streptozotocin induced neuropathic nociception. The neuropathic paradigms measured were static and dynamic mechanical allodynia (paw withdrawal threshold [PWT] to von Frey monofilaments and latency [PWL] to light brushing with a cotton bud), cold allodynia (paw withdrawal duration [PWD] to an acetone drop), heat hyperalgesia and hypoalgesia (increase and decrease PWL to a heat stimulus) and mechano-hyperalgesia (PWD to pin-prick), static and dynamic mechanical vulvodynia (flinching response threshold to the von Frey filaments pressure [FRT] and latency to light brushing [FRL] of the vulvar region). Additionally, any effect on the neuronal function produced after systemic and topical treatments was assessed using the paradigms of open field, rotarod, and footprint pattern analysis. For the systemic treatment, the antinociceptive doses for 6-methoxyflavone were 25, 50, and 75 mg/kg, while those of B. monnieri were 40 and 80 mg/kg. Gabapentin at 75 mg/kg was used as positive control. Topical gels of 6-methoxyflavone and B. monnieri were prepared in concentrations of 6% and 10% in relation to the clinically effective gabapentin gel. The relevant neuropathic nociceptive paradigms were successfully expressed in the operated hindpaw after placement of four loose ligatures around the sciatic nerve (days 3-21) and in both the hindpaws during the four weekly cisplatin injections and after the single injection of streptozotocin (days 7-28). These were exemplified as a significant decreased PWT to von Frey monofilaments, decreased PWL to cotton bud stroking and heat as well as an increased PWL to heat (cisplatin only), increased PWD to a drop of acetone and pin-prick, and decreased FRT to von Frey filaments and FRL to cotton bud (streptozotocin only). The daily systemic doses of 6-methoxyflavone and B. monnieri significantly attenuated the overall maintenance of mechanical and cold allodynia, mechanical and thermal hyperalgesia, heat hypoalgesia, and tactile vulvodynia during the expression days. Similarly, gabapentin treatment also afforded an analogous beneficial behavioral profile. The three times daily applications of the topical gels of 6-methoxyflavone and B. monnieri ipsilaterally but not contralaterally alleviated the neuropathic aberrations in the CCI induced nociception model and also in the cisplatin and streptozotocin induced polyneuropathy in both hindpaws. Accordingly, daily application of gabapentin gel on the mid-plantar area also showed a comparable suppression of neuropathic expression. However, the antinociceptive actions of gabapentin via the systemic route were associated with immobility along with motor impairment exemplified by a significant decrease in rotarod endurance latency and a deficit in the uniformity of step alternation. In Summary 3 contrast, the systemic and topical 6-methoxyflavone and B. monnieri were devoid of these unwanted effects and in fact the systemic treatments corrected these neuronal dysfunctions specifically associated with cisplatin and streptozotocin neuropathic models. The gabapentin 10% gel also afforded desirable neuropathic pain alleviating effects devoid of unwanted systemic side-effects, thereby indicating local antinociceptive actions for the topical gels. These outcomes suggest that systemic treatment with 6-methoxyflavone and B. monnieri afforded desirable neuropathic pain alleviating propensities when tested against an extensive range of nociceptive stimulus modalities without producing any gabapentin-like unwanted motoric side-effects. These findings also disclosed an expedient pharmacological validation of the effectiveness of topical route in the management of neuropathic pain. The systemic and topical 6-methoxyflavone and Bacopa monnieri can be used as an adjuvant therapy for pain conditions including neuropathic pain afflicted with allodynia and hyperalgesia and/or heat hypoalgesia as well as for diabetes associated vulvar pain. Further studies are advocated in other animal models along with clinical studies with regard to certain neuropathic pain syndromes in addition to elaborate pharmacodynamic and pharmacokinetic evaluation.