پروفیسر رشید احمد صدیقی کے قلب اور ذہن پر اقبال کے فکر و فلسفہ کا گہرا اثر دکھائی دیتا ہے دونوں کی باہم مراسلت بھی اس بات کا منہ بولتا ثبوت ہے کہ دونوں کے تعلقات بھی بہت گہرے تھے۔ اقبال گھریلو معاملات میں بھی رشید احمد صدیقی سے مشاورت کیا کرتے تھے۔ ان تعلقات کی جھلک دیکھنی ہوتو اقبال کے کئی خطوط ایسے ملیں گے جو رشید احمد صدیقی کے نام لکھے ہوں گے۔
پروفیسر عبد الحق نے رشید احمد صدیقی کا ثقافتی منظر نامہ ترتیب دیا ہے۔ صد سالہ جشن رشید کے موقع پر آپ نے دہلی یونیورسٹی میں ہونے والے ایک مذاکرے میں” رشید احمد صدیقی :افکار و اسالیب" کے عنوان سے جو مقالہ پڑھا وہ بہت پسند کیا گیا۔ آپ نے اس میں مزید اضافہ کیا۔ کچھ خطوط شامل کیے اور اس طرح ایک مکمل ترین عمدہ تصنیف سامنے آگئی۔ اس تصنیف میں جگہ جگہ اقبال کا ذکر پایا جاتا ہے۔ یہی وجہ ہے کہ پروفیسر عبد الحق نے رشید احمد صدیقی کی اقبال شناسی کے پہلو بھی نظر انداز نہیں کیے اور خود بھی عمدہ ترین تحقیق اور تنقید سے کام لے کر بہت اچھی تخلیق سامنے لائے ہیں۔ اس تصنیف کے موضوعات کا انفرادی جائزہ لیتے ہیں۔
Background: Hypertension is a growing medical and public health issue. The United States and European treatment guidelines have been issued to attain smooth control of hypertension in various categories of patients. It is a need of time to unveil safe combination therapies in various populations. Objectives: (i) To determine the efficacy of valsartan and hydrochlorothiazide versus valsartan and amlodipine (ii) To determine the safety and tolerability of both combinations. Materials & Methods: This experimental study was conducted at Shalamar Hospital Lahore. 126 patients with stage 2 hypertension were recruited from the medical outdoor of Shalamar Hospital Lahore after getting informed consent. In group A, 63 patients were given valsartan and hydrochlorothiazide. In group B, 63 patients were given valsartan and amlodipine. Blood pressure (BP) of both study groups was recorded on day zero, 2nd, 4th, and 8th weeks and the readings were entered on a Proforma. The efficacy of drug combinations was accessed in both groups by recording the change in mean systolic blood pressure (MSBP) and mean diastolic blood pressure (MDBP). The safety and tolerability of the drug combinations were assessed in terms of side effects and laboratory findings. Results: In group A, there was a 39±7mmzHg and 18±1mmHg decrease in MSBP and MDBP, respectively, from baseline BP. In group B, there was a 26.7±4mmHg and 14±2 mmHg decrease in MSBP and MDBP, respectively, from baseline BP. Both combinations were safe, and no significant difference in the efficacy of both combinations was observed after 8-week of treatment. Conclusion: Both combinations are effective for control of BP, but the valsartan and hydrochlorothiazide combination (group A) appears to have better tolerability and greater effect in decreasing BP as compared to the combination of valsartan and amlodipine (group B), although this difference is not statistically significant.
This dissertation reports physicochemical behaviour of some amphiphilic drugs as well as their interaction with anionogenic tensides (ionic surfactants) and Human serum albumin (HSA). A detail study of self aggregation of these drugs i.e. Clindamycine Phosphate (CLN), Quinacrine 2HCl (QUN), Chloroquine diphosphate (CLQ), Dexamethasone Sodium Phosphate (DSP) , Pefloxacin Mesylate (PFL), Citalopram HBr (CIT), Fluphenazine 2HCl (FLP), Trifluperazine 2HCl (TRF) and Certizine 2HCl (CRT) has been worked out. Surface tension and specific conductivity were measured to calculate the critical micelle concentration (CMC) of drugs and in this way their surface and thermodynamic parameters have been estimated. Surface activity was studied by measuring surface parameters i.e. surface pressure, Л, surface excess concentration, Г, area per molecule of ° drug and standard Gibbs free energy of adsorption, DGads . The electrical conductivity was measured as a function of concentration in the temperature range of 293-323K and CMC was determined. Consequently ° thermodynamic parameters like standard free energy of micellization, DGm , standard ° ° enthalpy of micellization, DH m and standard entropy of micellization, DS m were computed using closed association model. Aggregation properties of some structurally related drugs trifluperazine and fluphenazine and Quinacrine and Chloroquine have also been brought under study. For the most of drugs, association was found to be both enthalpy as well as entropy driven. Dexamethasone sodium phosphate, however, undergoes open association rather than micellization. We have also studied interaction of amphiphilic drugs with anionic surfactants sodium dodecyl sulfate (SDS) and cationic surfactant cetyltrimethyl ammonium bromide (CTAB). Aqueous micellar solutions of these surfactants were used for solublization of these drugs. The change of CMC of surfactant due to drug was determined by UV/Visible spectroscopy and conductivity method. UV/Visible spectroscopy was used to check the qualitative and quantitative features of this interaction and to calculate partition coefficient (Kx), free energy of partition and number of drug molecules per micelle while conductivity method is helpful to calculate different thermodynamic parameters. The complexation of amphiphilic drugs with HSA at physiological conditions (pH 3.0 and 7.4) have also been analyzed by using UV/Visible spectroscopy, fluorescence spectroscopy and dynamic laser light scattering. In this way values of drug-protein binding constant, number of binding sites and hydrodynamic radii were calculated and discussed in detail.