اس گردشِ جہان کا مارا ہوا وجود
لے جائیں ہم کہاں بھلا ہارا ہوا وجود
جزوی سا جسم لے کے ہی پھرتے رہے ہیں ہم
اب آ کے تیرے لمس سے سارا ہوا وجود
آدم کی لغزشوں کی سزا سَہ رہا ہے اب
دیکھو بہشت سے یہ اتارا ہوا وجود
اشکوں کا رِس گیا تھا نمک آنکھ سے دروں
میٹھے سے جا کے یوں سبھی کھارا ہوا وجود
پوجا ہے آفتابِ محبت کو ایک عمر
تب جا کے خاک سے ہے ستارا ہوا وجود
ہر سوچ میری فہدؔ ہے کندن سی اس لیے
بھٹی میں عشق کی ہے نکھارا ہوا وجود
Imam Khattabi is considered as a glorious scholar of the fourth century. He has written several books in various scholarly traditions. One of them an important book is "Ghareeb ul Hadith". In this, he has not only interpreted the difficult words but also referred to as Ayaat, Ahadith and verses etc. Then, he also described the jurisprudential commandments existed in these Ayaat and Ahadith. Furthermore, in many places, hadith terms, legal maxims and wisdom of law are also part of this book. This book also holds a significant correlation with knowledge of Imam Khattabi's teachers because he mentioned the ahadith and sayings of scholars with his own chain. Due to these qualities of this book, not only did the scholars of language use it, but also magnificent mohaddiseen, jurists, explainers and researchers have also quoted it in their own books. Of course, it will not be unwise to say that like previous scholars and mohaddiseen this book is also important and need for today's scholars.
Cancer is terrible disease. It is second leading cause of mortality worldwide. Conventional cancer therapies burdened the disease crippled patient with toxic side effects and are also very expensive. Therefore, the demand to use alternative approaches in treatment of cancer is increasing. Plant derived compounds due to their unique structure and sophisticated mechanism of action play promising role in anticancer therapies. The main objective of current study was to evaluate anticancer potential of medicinal flora of Pakistan. The plants used in current study are frequently utilized in folk medicines for treatment of many ailments in Pakistan. In present research work these traditional medicinal plants were scientifically examined for their antioxidant, antitumor, antimicrobial, anticancer and anti-inflammatory potential. Furthermore, chemical composition of the plant extracts was evaluated by state of art chromatographic techniques such as UV/Vis spectrophotometer, HPLC and GC-MS, revealed the presence of phenolics, flavonoids and broad range of other bioactive components in them. Antioxidant activity was estimated by free radical scavenging activity estimated by DPPH (1,1- diphenyl 2-picrylhydrazyl) assay. The outcome of antimicrobial activity assay showed that E. coli was the resistant strain to most of tested plant extracts. Overall, among the fungal strains, A. niger was the sensitive one. Furthermore, we examined antitumor activity by potato disc assay. Chloroform extract of V. betnocifolia (IC50= 38.13 μg/mL) exhibited maximum antitumor activity. We determined anticancer activity of different plant extracts against human cancer cell lines (KBM, mylegeous leukemia; U266, multiple myeloma; SCC4, tongue squamous carcinoma and HCT116, colon carcinoma cells) by MTT assay. The extracts with maximum anticancer activity against human mylegeous leukemia (KBM5) cells were examined for inhibition of inflammatory transcription factor, nuclear factor kappa B (NF-kB). Surprisingly all the plant extracts inhibited TNF-α induced NF-kB activation.