شعر و ادب کو پروان چڑھانے میں ادبی شخصیتوں کا اپنا مقام و مرتبہ ہے یہ کیسے ہو سکتا تھا کہ رسائل و جرائد اور اخبارات ان سے پیچھے رہتے خطہ سیالکوٹ کے مقامی رسائل و جرائد اور اخبارات ادب کی ترقی کے لیے ماضی سے اہم خدمات سر انجام دیتے چلے آرہے ہیں۔ان میں ’’نوائے سماج‘‘،’’ندائے سیالکوٹ‘‘،’’ہمدرد پاکستان‘‘ ،’’محنت کش‘‘ اور ’’شبنم‘‘ اہم رسائل و جرائد میں شمار ہوتے ہیں۔ان رسائل و جرائد اور اخبارات کے باقاعدہ ادبی ایڈیشن بھی شائع ہوتے رہے ہیں۔
سیالکوٹ کے اخبارات کی موجودہ صف میں ’’صدائے شہر‘‘ ،’’نوائے شمال‘‘ اور ’’اخبار سیالکوٹ‘‘ نمایاں اخبارات ہیں۔رسائل و جرائد کی فہرست میں ’’مرے کالج میگزین ‘‘،’’مفکر‘‘،’’کاوش‘‘، ’’افق‘‘،’’محورِحیات ‘‘، ’’اقدار‘‘، ’’ادراک‘‘، ’’انتخاب‘‘، ’’کیہان‘‘، ’’یدبیضا‘‘، ’’گجر‘‘، ’’کرائیڈن‘‘، اور’’سٹی میگ‘‘آج بھی ادبی خدمات میں اہم کردار ادا کر رہے ہیں۔
’’گجر‘‘ ،’’انتخاب‘‘،’’ید بیضا‘‘ تاب اسلم کے شعور و فکر کا نچوڑ ہیں ان تینوں رسائل وجرائد کو تاب اسلم بڑی عرق ریزی سے ادبی دنیا کے سامنے پیش کرتے رہے ہیں۔ان ادبی رسائل نے بہت سے نئے لکھنے والوں کی راہنمائی کا فریضہ سر انجام دیا ہے۔تاب اسلم کے ان جرائد کو نہ صرف سیالکوٹ بلکہ برصغیر پاک و ہند کے نامور ادبا و شعرا ،ناقدین اور محققین کا قلمی تعاون حاصل رہا۔سیالکوٹ کے اہم ادبی رسائل و جرائد کے تعارف کے لیے تفصیل پیش کی جاتی ہے۔
۱۔ مر ے کالج میگزین :
مرے کالج میگزین کا پہلا شمار ہ نومبر...
Islam is the name of goodwill, and Islamic state takes into consideration all benefits for their all inhabitants, belonging to this world or hereafter. In this regard an Islamic state has a status of mother, who keeps spirit of love for all his inhabitants and who doesn’t differentiate between Muslim and non-Muslim for the delivery of rights because the head of Islamic state or khalifa will be busy to emulate rules of owner Allah Almighty (S.W) and never interfere in the handover system nor seek any personal benefit, however he will be doing sincere effort to play his role the same way which is assigned to him. Since there is no existence of Muslim state in present day structure, so in this discussion it will be attempted to differentiate between an Islamic state and Muslims state in role and behavior, which will cover the following areas. The structure of Islamic state and institutional principles The role and status of an Islamic state in world politics Present Muslims state’s status and their role in world politics and affairs as will.
A combinatorial synthesis of small libraries of a variety of amino chalcones has been carried out in solution phase under standard Claisen Schmidt conditions. The compounds were tested for their potential as antibacterial and cytotoxic agents as well as phosphatase inhibitors and the leads were identified in each bioassay. Chalcone 7 was found to have strongest potential as cytotoxic agent, while chalcone 11 be the most potent PGM inhibitory agent. Parallel synthesis of a 120 member chalcone library was carried out as mixture synthesis following the positional scanning protocol. The identification of lead in this library was carried out by deconvulution and chalcones 22 and 41 were found to be the most potential candidates to be developed as antibacterial agents. Following the same strategy of mixture synthesis, another 175 member chalcones library was synthesized and most potent anticancer chalcones 31, 61 and 78 were identified by deconvolution through position scanning protocol. Peptidyl α,β- unsaturated ketones were synthesized as novel bis- electrophiles susceptible for 3+2 and 3+4 annulations. As a result, peptidyl oxazoles, pyrazolines, pyrazoles, benzothiazepines and benzodiazepines were synthesized. Potent antidiabetic chalcones were docked into the PGM active site and a rationale was found for greater antidiabetic activity of chalcones over the other. Rational design and synthesis of some cytotoxic chalcones was based on 3DQSAR studies using CoMFA as a tool. 3DQSAR studies were also carried out on a library of 30 chalcones as potential antitumor agents.