ڈاکٹر یعقوب صروف
اڈیٹر المقتطف کی وفات، علمی حلقہ میں یہ خبر نہایت افسوس کے ساتھ سنی جائے گی کہ مصر کے مشہور علمی، صنعتی، زراعتی اور فلسفیانہ رسالہ المقتطف کے دوسرے اڈیٹر ڈاکٹر یعقوب صروف نے بھی جولائی ۱۹۲۷ء کو وفات پائی۔ یہ وہ شامی اہل قلم ہے جس نے عربی ممالک میں سب سے پہلے سائنس، حکمیات، فلسفہ اور اختراعات جدیدہ کے معلومات بہم پہنچائے اور پورے پچاس برس اس نے اس اہم خدمت کو انجام دیا۔ ۱۸۷۶ء میں اس نے اس رسالہ کو جاری کیا تھا اور اب تک اسی طرح پوری شان کے ساتھ جاری رہا۔ ان کی پیدائش ۱۸ء میں ہوئی تھی۔ بیروت امریکن کالج میں تعلیم پائی تھی اور پھر وہیں ریاضیات کے پروفیسر مقرر ہوگئے تھے۔ وہیں اس رسالہ کی اشاعت کا اس کو اور اس کے رفیق فارس نمر کو جو پہلے وفات پاچکا ہے، خیال آیا تھا۔ ترکی حکومت نے اپنی اجازت سے ان کی ہمت افزائی کی۔ آخر یہ مصر میں آکر تکمیل کو پہنچا۔ یعقوب صروف کے بعد فواد صروف نے اس رسالہ کی زمامِ ادارت اپنے ہاتھ میں لی ہے۔
(ریاست علی ندوی، ستمبر ۱۹۲۷ء)
The variety and difference in natural capabilities of a nation can be observed in their conversational skills. If the mental level of an individual has properly grown up, his power of expression, vocabulary and style of reasoning will be defiantly of high standard as compared to a common man. Similarly, when these skills get a literary shape it become more standardized. “Al Nazaha” is the art of the speech having similarity with satire (هجو )to a level but is different in many aspects with respect to its application, such as purification of plebian words )كالم سوقيانه, )reformative critical outlook and broad thinking etc. This article deals with the art of speech )النزاهة )its introduction and utilization in the Arabic and Islamic sources
MicroRNAs (miRNAs) are short, endogenous and non-protein coding RNAs that are 18-26 nucleotides (nt) in length. The main function of the miRNAs is to negatively control the protein coding sequences at post-transcriptional level. By nature majority of the miRNAs are evolutionarily conserved. This conserved nature provides the logic to predict the new miRNAs orthologus in a number of plant species. In plants, miRNAs are involved in almost all biological processes from growth and development to biotic and abiotic stresses with metabolism, apoptosis and cell signaling. In the current dissertation, various computational tools were used for the profiling and characterization of new conserved miRNAs and their targets in four important vegetables of Solanaceae viz: tomato (Solanum lycopersicum L.), potato (Solanum tuberosum L.), eggplant (Solanum melongena L.) and chilli (Capsicum annuum L.). Consequently, a total of 393 miRNAs (belonging to 364 miRNA families) were discovered from the mining of 7,63,564 express sequence tags (ESTs). Of which, 120 miRNAs (110 miRNA families) were from potato, 109 miRNAs (106 miRNA families) from tomato, 88 miRNAs (81 miRNA families) from chilli and 76 miRNAs (67 miRNA families) were from eggplant. In this study, a total of three miRNA genes were found as pre-miRNA clusters, where, two belong to chilli (can-mir-8019 and can-mir-8036) and one is from potato (stu-mir-6164). One potato miRNA family stu-mir-8123 was also found both as an antisense (mir8123a) and sense (mir8123b). A total of thirty randomly selected miRNAs were subjected to reverse transcription-PCR (RT-PCR) validation studies. Furthermore, a total of 1592 protein targets were also predicted for these newly profiled miRNAs. These predicted protein targets were classified as: transcription factor, stress related, disease related, growth and development, hypothetical protein, transporters, signaling pathways, metabolism and structural protein. All of these newly identified miRNAs were reported in tomato, potato, eggplant and chilli for the first time. These results will serve as reference data to improve the regulation, management, and modification of these economically important crops at the molecular level. This will also help us to improve solanum plants for production and biotic and abiotic stress tolerance in the near future.