Reducing the Effects of Blood Sugar Infusion of Melastoma Malabathricum L. In Mus Musculus

This study aims to determine the blood sugar-lowering effect of Melastoma malabathricum L. Infusion on Mus musculus. The research design used was an experimental laboratory carried out in the pharmacology laboratory of the Ho Chi Minh City University. This study used 15 male mice which were divided into 5 groups consisting of group I as negative control by giving aquadest, groups II, III, IV were given infusion of Melastoma malabathricum L. Respectively 0.1 g/ml, 0.2 g/ml, and 0.4 g/ml, and group V as a positive control with glibenclamide suspension. The results showed that statistical testing using the SPSS program showed a significant difference (p <0.05), which means that senggani leaf infusion had a significant effect on reducing blood sugar levels in mice and the most optimal was 0.4 g/ml infusion.

Early Onset Type 2 Diabetes and Associated Risk Factors

Background: The incidence of type 2 diabetes in patients below the age of 40 (early onset diabetes) is markedly on the rise and has been linked increased prevalence of risk factors such as the metabolic syndrome and family history of diabetes. Objective: To determine the proportion of patients with type 2 diabetes at Aga Khan University Hospital Nairobi (AKUHN) who have early onset type 2 diabetes and the association of age of onset with risk factors (family history of diabetes, obesity, waist circumference, hypertension, low HDL cholesterol and hypertriglyceridaemia) in this group of patients. Methods: This was a cross sectional study. All adult patients with type 2 diabetes presenting to the AKUHN diabetic clinic from 1 February to 30 April 2012 who consented to participate were included. A data collection form was completed documenting patient demographics, anthropometric measurements and fasting lipid profile. Results: A total of 140 patients were recruited. Males comprised 59.3%. Mean age at diagnosis was 48.1 years. The proportion of patients with early onset Diabetes was 24% (95%CI 17%-31%). Patients with early onset diabetes were more likely to have a relative with diabetes compared to the usual onset group (OR 3.58; p< 0.009). There was a positive association with early onset diabetes and having a first degree relative with diabetes (OR 3.92; P<0.007) and having two relatives with diabetes (OR 5.11; P<0.017). Patients with early onset diabetes were more likely to have hypertriglyceridaemia (OR 1.82; p<0.187). This study did not find a positive association with early onset of diabetes and abdominal obesity (OR 0.74; P<0.600), hypertension (OR 0.3; P<0.004), abnormal BMI (OR 0.61; P<0.448) or low HDl-Cholesterol (OR 1.01; P<0.982). Conclusion: There is a high proportion of early onset type 2 diabetes in this study population which was associated with having a family history of diabetes, a first degree relative with diabetes and more than one diabetic relative.