Antibacterial substances may be synthetic, semi-synthetic or derived from natural materials. They were recognized as miracle drugs if they had strong effectiveness against harmful microorganisms and were recovered suffering patients as soon as possible. However, they become multiple resistant to pathogens if they were used improperly. This multidrug resistant problem had become a major challenge for global healthcare practitioners. The major cause of this problem was the continuous spreading of drug resistant bacteria by different processes. So to overcome such problems some new methods had been developed. These methodologies had replaced conventional antibiotics to control the multiple drug resistance. Among these technologies one of them is the green synthesis of cefditoren derived silver nano particles (AgNPs). They were synthesized via a simple one-pot method after mixing AgNO 3 and cefditoren in NaOH aqueous solution. These synthesized nanoparticles were characterized by UV-Visible Spectroscopy and Fourier transform Infrared (FT- IR) spectroscopy. Cefditoren and synthesized AgNPs solutions were tested against three-gram positive bacterial species like Streptococcus pneumoniae, Streptococcus pyogenes and Staphylococcus aureus. The data revealed that cefditoren showed little inhibition against all tested bacterial species while cefditoren derived AgNPs showed maximum activities against all these three bacteria. These activities were dose dependent when compared to cefditoren. These findings could pave the way for finding the changing behavior associated with other antibiotics after capping AgNPs or other metal nano particles and may be used against other resistant strains.