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Home > Screening of Phytochemicals Against Cysteinyl Leukotriene Receptor 1 Through Molecular Docking

Screening of Phytochemicals Against Cysteinyl Leukotriene Receptor 1 Through Molecular Docking

Thesis Info

Access Option

External Link

Author

Namrah Noor

Institute

Virtual University of Pakistan

Institute Type

Public

City

Lahore

Province

Punjab

Country

Pakistan

Thesis Completing Year

2017

Thesis Completion Status

Completed

Subject

Software Engineering

Language

English

Link

http://vspace.vu.edu.pk/detail.aspx?id=128

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676720972952

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Asthma is one of the most frequent disorders being observed in clinical practices. Cysteinyl leukotrienes (CysLTs) are the main mediators of the entire allergic reactions and also a vital part of the inflammatory reactions that lead to the usual symptoms of asthma. Montelukast and Zafirlukast are known leukotriene receptor antagonists prescribed in asthma treatment. However, these fall short as mono therapy and are frequently used in combination with inhaled glucocorticosteroids with or without long acting beta 2 agonists. Therefore, it is of interest to apply ligand and structure based virtual screening strategies to identify compounds better than lead compounds i.e., Montelukast and Zafirlukast. The aim of the present study was to identify the novel phytochemicals of anti-asthma plants against cysteinyl leukotriene receptor 1, which had more antagonizing potential as compared to Montelukast and Zafirlukast and could be helpful to control the asthma disease. For this purpose, 1216 phytochemicals of 54 medicinal plants against cysteinyl leukotriene receptor 1 were screened. Montelukast and Zafirlukast were selected as lead compounds. Phytochemicals were retrieved from NCBI?s PubChem database and grouped and docked at the antagonist binding site of cysteinyl leukotriene receptor 1. Results showed that five phytochemicals (Phytic acid, Heptacosanol, Triacontane, Nonacosan-15-one, n- hentriacontanol of plants solanum nigrum, tinospora cordifolia, pipper betel linn, tinospora cordifolia and vitex negundo respectively) had higher predicted binding as compared to Zafirlukast and Montelukast. However, among five identified phytochemicals, the phytic acid showed highest appreciable S score. Results of this study may be used in computer aided screening of the drugs against asthma disease.
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خلاصہ بحث

اسلام میں عبادات انسانی فطرت کے عین مطابق ہیں، ہر بچہ فطرتِ سلیمہ پر پیدا ہوتا ہے اور اس طرح ہر انسان فطرتاً اپنے خالق کے وجود کے اقرار کی طرف مائل ہوتا ہے۔ اسی فطری جذبے کو پروان چڑھانے اور اسی روحانی پہلو کو جلا بخشنے کے لیے عبادات مقرر کی گئی ہیں تاکہ انسان اپنی روحانی پیاس بجھا سکے۔ اسلام نے عبادات مقرر کرتے ہوئے انسانی زندگی کے حالات کو پیشِ نظر رکھا ہے اسی لیے راہبوں کی طرف دنیا سے الگ تھلگ ہو کر عبادت خانوں میں بند ہونے کی اجازت نہیں دی۔ ہر عبادت کی صورت اور طریقِ ادائیگی دوسرے سے مختلف ہے۔اپنی زندگی کو اللہ تعالیٰ کی شریعت اور اس کی مرضی کے مطابق گزارنے کا نام عبادت ہے۔ انسان کے تمام اعمال خواہ وہ دنیوی مفادات کے حصول کے لیے ہی کیے جائیں عبادت بن جاتے ہیں بشرطیکہ ان سے رضائے الٰہی مقصود ہو۔ اس فصل میں عبادات سے متعلقہ آیاتِ استفہام بیان کی گئی ہیں اور جو ان میں پوشیدہ حکمت جس مقصد کے لئے سوال کیے گئے ہیں اس کی وضاحت کی گئی ہے جو کہ درج ذیل ہیں:

عبادت تمام ظاہری اور باطنی اقوال اقوال و اعمال کو شامل ہے جنہیں اللہ تبارک و تعالیٰ پسند فرماتے ہیں اور اللہ تعالی ان سے راضی ہوتے ہیں عبادت ان تمام چیزوں سے بیزاری کا نام ہے جو اللہ تعالی کی رضا اور اللہ تعالی کی پسند کے خلاف ہو اور عبادت کے معنی ہیں کہ اللہ کی رضا کے لئے انتہائی عاجزی اور خشوع کا اظہار کرنا ، اللہ تعالی سے محبت کی یہ نشانی ہیں ہیں کہ انسان وہی چیز پسند کرے جو اللہ تبارک و تعالیٰ نے حکم دیا ہے اور اس چیز سے عداوت و نفرت رکھے جسے اللہ تبارک و تعالی...

الأصوات العربية الفرعية في الدراسات الصوتية

يهدف هذا البحث إلى المساعدة على التعرف على كيفية تركيب الألفاظ العربية من حيث إتيان الحروف المجاورة في بنائها، وعند جمع أربعة أو أكثر في التلفظ بها. ويعين على تمييز الألفاظ الأعجمية التي لها ألفاظ عربية. واتبع الباحث المنهج الوصفي التحليلي في إجراء البحث. وفي ضوء ما تم تناوله تم التوصل إلى النتائج الآتية: 1- أن تصنيف الحروف الفرعية إلى مستحسن ومستقبح راجع عند القدماء لمبدأ الكثرة والقلة، فما كثر استعماله كان مستحسنا، وما قل استعماله وصف بالاستقباح. 2- تمثل الحروف الفرعية ألوانا من الآراء يعكس اختلاف القبائل العربية آدابها، وهي من صور الأداء المعروفة، مما جعل العلماء يقومون ببيان خواصها الصوتية. 3- جاءت هذه الحروف لإحداث نوع من التناسق والإنسجام في البنية الصوتية.

Prevalence of Non-Alcoholic Fatty Liver Disease in Overweight and Obese Children Seeking Ambulatory Health Services in Nairobi

Introduction: Non-alcoholic fatty liver disease is often an asymptomatic condition one of the leading causes of chronic liver disease and is associated with an increase in cardiovascular morbidity. Being overweight or obese has been positively linked to non-alcoholic fatty liver disease in children. There is evidence to show that when detected early, non-alcoholic fatty liver disease is reversible primarily upon institution of lifestyle changes targeted at weight reduction. Establishing the prevalence of non-alcoholic fatty liver disease in overweight and obese Kenyan children would serve as a benchmark for long term monitoring of associated morbidity and guide in public health policies aimed at early screening and intervention. Objectives: The aim of this study was to investigate prevalence of non-alcoholic fatty liver disease in overweight and obese children aged between six and eighteen years using liver ultrasonography. Methodology: A descriptive cross sectional study was carried out in 103 overweight and obese school aged children aged six to eighteen years seeking ambulatory health care services in Nairobi. Consent was obtained from the primary caregivers. A questionnaire was administered to collect information on bio data. Blood pressure readings were taken and plotted in age and gender specific charts and a liver ultrasound was done to assess and grade fatty changes. Data Analysis: Statistical analyses were conducted using SPSS version 11.5 (SPSS, Chicago, IL, USA). Categorical variables were analyzed using median (IQR) and summarized using frequency counts and percentages. Chi-square test was used to determine odds ratios for association between presence of fatty liver and other categorical variables using 2x2 tables. All clinically important variables were then included in multiple logistic regression model adjusting for age and sex to find if there was any association with fatty liver. All analyses were two-tailed and P-value less than 0.05 was considered statistically significant. Results: A total of 103 children were recruited in the study. The prevalence of fatty liver change was 26.2% (27/103; 95%CI=18.0%-35.8 %). There was no association between sex and fatty liver disease (OR=1.13, p=0.82; 95%CI=0.4-3.2) Obese children were four times more likely to have fatty liver compared to overweight children (OR=4.52 p=0.02, 95%CI=1.4-19.0). Slightly more than a third of the children, 40.8% (n=41) had elevated blood pressure. However, there was no association between elevated blood pressure and fatty liver disease (OR=2.06; p=0.27; 95%CI=0.6-7.6). Older children (13-18 years) were four times more likely to have fatty liver vi