Fish is primary protein source for human being in the world. Heavy metal contamination is producing destructive change in histology and morphology of fishes. It decreases growth and development and increases mortality rate. A total of 41 fish(Eutropiithys vacha) specimens were captured from River Indus, Head Tounsa, during October2016 to check the effect of heavy metal in the fish by Atomic Absorption spectrometry. Cadmium in E. vacha showed highly significant positive correlation with wet weight of body and body burden with the value of (r=0.829). While, concentration of chromium showed significant positive correlation with wet weight of the body and body burden with the value of (r=0.480) in E. vacha. Fish cadmium concentration showed highly significant positive correlation with totalbody length relation to the concentration of elements. Total length of body with cadmium were highly significant with (r=0.739), while the chromium showed a significance (P<0.01) correlation with total length and burden element of body with the value of (r=0.413). Condition factor for E. vacha range from 0.447 to 0.930. Cadmium (r= 0.330) in fish shows least significant value while chromium (r=0.172) have non-significant correlation with that of condition factor in relation to element concentration. Cadmium (r= 0.289) and Chromium (r= 0.289) shows non-significant relationship, when correlated or interelemental relationship with one another in wet body weight of E.vacha (in wet weight of body).