Drugs contain the different component with different dosage concentration and some of them
cause the toxicity in liver and kidney. In current study, male wistar rats were divided into three
groups and kept in the animal house of the University of Health Sciences Lahore under standard
conditions. Group I was serve as control while Group II and III had given by benzaldehyde and
salicyldehyde derivative of pregabalin for 28 days, respectively. The behavioral changes, body
weight and eating habits were remained same in all groups. There was not mortality rate occur in
all groups. After sacrificing the animals, it was observed that there is not morphological and
gross change in the color and texture of the liver and kidney. Hematological analysis has not
showed the any significant difference in leukocyte count and MCV, platelet count, hemoglobin
concentration (Hb), packed cell volume (PCV), erythrocyte count, mean corpuscular hemoglobin
(MCH) and mean corpuscular hemoglobin concentration (MCHC). Biochemical analysis showed
the elevation in AST and creatinine while the vales of bilirubin, BUN and ALT remain normal.