From the past few decades, multiple drug resistivity problems rise day by day. Drugs become resistant over microorganisms like bacteria,fungi, algae etc. To overcome such kinds of resistivity problems researchers have adopted many new ways and methodologies. From these methodologies, one way is to cap nanoparticles with different drugs which may replace conventional antibiotics with these stabilized drugs. Erythromycin stabilized silvernanoparticles (Ery-Ag(0) NPs)werecombined by using AgNO 3 with the assistance of erythromycin by using a facile method. The synthesized(Ery-Ag (0) NPs) wasobserved by UV-Vis absorption spectroscopy, which inveterate the formation of (Ery-Ag(0) NPs)by stimulating the characteristic surface Plasmon absorption maxima at 400-420nm. While the confirmation of bonding of specific drug with silver metal exhibited, the formation of silver nanoparticles was verified by FTIR.X-ray powder diffraction (XRD) confirmed the crystalline nature of synthesized Ag (0) NPs. The standard condition employed for the optimization of this experiment. The effects of (Ery-Ag(0) NPs) were checked on Salmonella typhimurium?(S. typhimurium)and?Aspergillus niger (A. niger).Well diffusion method was used to check the antimicrobial activity on S. typhimurium?and?A. niger, and inhibition zone was in mm to check capability of the capped (Ery-Ag(0) NPs). The results were compared with standard erythromycin. The antibacterial and antifungal results revealedthat newly synthesized (Ery-Ag(0) NPs) had aremarkable activity against S. typhimurium and?A. niger.The results could pave the new ways against multiple drug resistance. The resistance problems caused by conventional drugs and microbial activities by reduction or degradation methods show remarkable and efficient outcomes.