Tilapia (Oreochromis mossambicus) found in Pakistan is dull in shading. Tilapias are the most effectively popular on the planet in view of their quickly developing and high proficient to use the normal and as supplemented nourishment. It is very important because of ecological and reproducing weights. It lives for up to 11 years. Present study was undertaken to observe the influence of varying yeast levels (0%, 30% and 35% dietary yeast) on proximate body composition of tilapia from Government Fish Hatchery Multan. The experiment was conducted for 2 months trail from October to November in 2017. At the start and end of the experiment the whole body composition of fish was analyzed.The purpose toperform this experiment trial was to determine the efficiency of different levels of fishmeal yeast as source with basal fish diet on growth of (Oreochromis mossambicus) fingerlings. Fingerlings of (Oreochromis mossambicus) were rear under intensive culture for a period of 60 days. These experiments was checked the impacts of three unique eating regimens on the development execution of fingerlings of (Oreochromis mossambicus) 280 liter water volume was used for stocking density 25/glass fish aquarium for fingerlings of (Oreochromis mossambicus). Controls diets was contained no fishmeal in basal diet as 0%. Other two groups were fed fishmeal at levels of 30 % and 35% along with the basal diet. Fingerlings were fed daily4% of their body weight. Fingerlings were feed two times in a day. In this experiment target was tocheck the impact of various levels of fishmeal on the development execution, encourage change proportion, survival rate of fingerlings of (Oreochromis mossambicus). There was increment in development, mean body weight, mean body length, of fingerlings of Oreochromis mossambicus. The survival rate was 100% under this nourishment. Temperature and water quality, were most vital parameters for development and survival of fingerlings of Oreochromis mossambicus. Simulated light and oxygen was given in aquarium.This was estimated that with the increase of yeast level in diet, fish fingerlings were highly grew in size. Body composition of fish was effected with varying yeast levels in artificial diet. The information of these parameters helps to selectOreochromis mossambicus as major diet because it contains higher protein content and is suitable for human consumption. In the whole wet body weight of the Oreochromis mossambicusmean percentages for water, fat, protein,ash contents were 84.52, 27.50 dry, 4.31 wet, 71.64 dry, 11.03 wet, 24.81 dry, 3.82 wet respectively in this study in all treatments. Higher average water, protein, fat, ash percentage and minimum dry weight percentage were observed with increasing the crude protein in artificial fed treatment 3 in which fish was fed with 35% yeast in artificial diet. Highest percentage of protein (71.64%) and lowest percentage of dry (15.48%) was observed in and ash observed in treatment 3 was 24.1 % and 3.82% respectively. The major contribution was to find out nutritional impacts of this fish through proximate analysis of body constituents of fish and find out the optimum dietary yeast level of fish feed at which fish give maximum nutritional value.