اور جہاز پھٹ گیا
پہلی اورآخری بار غلام اسحاق خان اچھا لگا اور جہاز پھٹ گیا کی وجہ سے میری رہائی جو 2009ء میں 25سال بعد ہو نی تھی ۔1988میں ہو گئی ۔
17August1988
ہم لوگ اڈیالہ جیل راولپنڈی میںتھے جیل کی گنتی بند ہو چکی تھی کہ اچانک جیل کے اندر عام قیدیوں کے نعروں کی آواز گو نجنے لگی ۔میں جیل کی ڈیوٹی پر موجود سپاہی سے پوچھا کہ کیا ہوا ہے ۔ اس نے کہا اڑتی اڑتی خبر آئی ہے کہ جنرل ضیاء الحق کا جہاز کریش ہو گیا ہے پاکستانی خبریں تو ہم کم ہی سنتے تھے اس دن ریڈیو لگایا تو جنرل ضیاء الحق کے مرنے کی خبر تھی ۔کانوںکو یقین نہیں آ رہا تھا ۔ مجھے اپنی ماںیاد آ گئی جب میری سزائے موت عمر قید میں تبدیل ہو ئی تو وہ مٹھائی لے کر آئیں میںنے کہا مجھے 25سال سزا ہو ئی ہے وہ بولیں کہ زندگی بچ گئی اب مجھے پتہ ہے کہ جب تک جنرل ضیاہے تم جیل میں ہو ۔ہزاروں مائوں کی سنی گئی ۔دسمبر 88میں محترمہ بے نظیر بھٹو شہید کی حکومت بننے کے بعد پاکستان بھر کی جیلوں میں موجود ہزاروں سیاسی قیدی رہا ہوئے وگرنہ میری رہائی مارچ 2009ء میں 25سال بعد ہو نی تھی ۔
In this paper, based on the primary sources, an attempt has been made to discuss the contribution and services of Mawlānā Abū Yūsuf Muḥammad Sharīf (d. January 1951) commonly known as Faqīh-i-Ā‘ẓam and Muḥaddith-i-Koṯalwī in the field of Ḥadīth, the second most important source of Islamic Law. Mawlānā Muḥaddith-i-Koṯalwī having a deep insight in the Science of Ḥadīth has written extensively on this facet of Islamic learning. Mawlānā Abū Yūsuf Muḥammad Sharīf Muḥaddith-i-Koṯalwī through his fatāwā, articles, sermons and books done a great service for the Science of Ḥadīth. He has explained the five pillars of Islam and other rituals in the light of different āḥādīth. Being a Ḥanafī ‘ālim, Mawlānā Muḥaddith-i-Koṯalwī also proved that the Fiqh-i-Ḥanafī, the most popular fiqh among the South Asian Muslims, is in accordance with the authentic āḥādīth. He has also discussed the difference between a Ḥadīth and Sunnah.
Present thesis describes the synthesis, characterization and biological screening of sulfonamide ligands; their complexes and five membered heterocyclic ligands (Thiohydantoin ligands); their complexes aiming in search of new candidates to fight with microorganisms. Thanks to metals for being the charm of medicinal and pharmaceutical chemistry since many decades. To extend this search, 20 ligands were synthesized. Ligands containing sulfonamide moieties are prepared by the reaction of ten different amino acids with p-toluene sulfonyl chloride. The compounds are isolated in pure form and checked by TLC. The single crystal structure of the compounds is also reported and dicussed.These compounds were then reacted with transition metals e.g, Zn (II), Sb (III) chloride and Sb (III) bromide and thirty new metal complexes have been synthesized. Further, these sulfonamide derivatives were cyclized in the presence of NH 4 SCN, acetic anhydride and base to form 5-membered heterocyclic ring containing thio group. Forty, new complexes of these thiohydantoins with transition metals e.g. Zn (II), Sb (III) chloride and Sb (III) bromide have been synthesized. All of the synthesized complexes were heat, air and moisture stable after formation, but during the complex formation, moisture and air was avoided to prevent the oxidation of the compounds using standard schlenk line and glove box techniques. The stability profile enhances the link between organometallics and drug design and discovery. Purity of all of the synthesized compounds was conventionally monitored with the help of TLC in different solvent systems. All of the synthesized compounds and their complexes with transition metals were characterized by elemental analysis, FTIR, GC- MS and 1 H NMR , 13 C NMR spectroscopy, the structure was finally confirmed with the help of single crystal structure. All the characterization data is reported in this work and discussed. All the synthesized compounds and their metal complexes were evaluated for their carbonic anhydrase, intestinal alkaline phosphate inhibition, antileshminial, anti oxidant, anticancer and antibacterial activities. The results of these bioassays are also reported and discussed in detail, e.g., the sulfonamide ligands showed excellent carbonic anhydrase activities, while the activity was enhanced 40-60% in case of zinc complexes but the antimony (III) complexes have showed slightly less CA activities. Similarly, the complexes of antimony with sulfonamide ligands have showed excellent antileshminial activities, while the zinc (II) complexes have showed comparatively less activities. Moreover, the results of intestinal alkaline phosphatase activities iiihave proved that the metal complexes of sulfonamide and thiohydantoin ligands have showed increased activities as compared to parent sulfonamide ligands. Additionally, the said complexes also showed enhanced cytotoxic activities against BHK-21 and H-157 cell lines. The antibacterial activity against Gram –ve and Gram +ve bacteria were outstanding in case of metal complexes of the sulfonamides. Results of antibacterial evaluation of all the compounds as percent inhibition against these bacteria are reported and discussed. The activity of different synthesized compounds as percentage inhibition against concentration and time are included and discussed in detail. We can summarize by saying that the newly synthesized ligands and their metal complexes have provided important candidates for drug discovery which can be further improved to be used as drugs with enhanced pharmacological action and lesser side effects.