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Home > Computational Analysis of Functional Single Nucleotide Polymorphism Associated With Bcl2 Gene

Computational Analysis of Functional Single Nucleotide Polymorphism Associated With Bcl2 Gene

Thesis Info

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Author

Asim Khurshid

Institute

Virtual University of Pakistan

Institute Type

Public

City

Lahore

Province

Punjab

Country

Pakistan

Thesis Completing Year

2018

Thesis Completion Status

Completed

Subject

Software Engineering

Language

English

Link

http://vspace.vu.edu.pk/detail.aspx?id=224

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676720999417

Similar


Most persistent genomic variations are marked as single nucleotide polymorphisms called SNPs, and these are strongly linked to certain disease. Some of these SNPs are known as missense SNPs (nsSNPs) which are residing in the translation region of gene causing an effect on the amino acid composition. Resultantly, these have a deep effect on protein structural and functional aspects. In human the SNPs are very crucial type of variations which are very common and engage in a vital role in the human genetics pheno-type variations. These SNPs are the genetic basis of complex diseases in human. In human, the role of certain gene like B Cell Lymphoma 2 (BCL2) has got special attention because it?s over expression is resulting in certain type of lymphocytes cancer, because this gene encodes the outer mitochondrial membrane and blocks the apoptotic cell death in lymphocytes, resulting the formation of follicular lymphoma a type of cancer. In this research the role of Functional SNPs is studied by applying different computational methods to narrow down the mis-sense impact of deleterious SNPs. In This study 137 nsSNPs in BCL2 gene were investigated through computational techniques like SIFT, Polyphen2, I-Mutant 2.0 along with ConSurf web server and different nsSNPS were having common results studied for potential impact on the functioning and structural variations of BCL2 protein. Furthermore, Micro Dynamics Simulation analysis of the structure lead to the confirmation of effect of nsSNPs on the consistency and secondary property of BCL2 Protein. The tools like UTRScan (UTRdb), MirSNP, PolymiRTS and miRNASNP predicted to show the pattern changes in UTR-SNP. The recording of missense SNPs is very much beneficial for reduction of the mutations in BCL2 gene in genetic association studies to understand the function and structure related aspects of BCL2 Protein.
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مولانا نجم الدین اصلاحی

مولانا نجم الدین اصلاحی
۱۴؍ اگست کو حافظ مولانا نجم الدین صاحب اصلاحی نے تقریباً ۹۴ برس کی عمر میں داعی اجل کو لبیک کہا۔ اِناﷲ وَاِنا اِلَیہ رَاجِعُون۔
انھوں نے اپنے جدبزرگوار ملاقدرت علی مرحوم سے ابتدائی تعلیم حاصل کی اور اپنے گاؤں ہی کے ایک دوسرے بزرگ حافظ عبدالرحیم مرحوم کی خدمت میں رہ کر قرآن مجید حفظ کیا، مزید تعلیم مدرسۃ الاصلاح سرائمیر میں ہوئی، اس وقت مدرسہ میں مولانا امین احسن اصلاحی صاحبِ تدبر قرآن اور مولانا اختر احسن اصلاحی مرحوم سابق مہتمم مدرسۃ الاصلاح بھی زیر تعلیم تھے۔ فارسی میں مولانا نجم الدین صاحب کی اچھی اور پختہ استعداد ان کے ہم وطن مولوی محمد مصطفےٰ صاحب کے فیض تلمذ کا نتیجہ تھی۔ جو مدرسۃ الاصلاح میں فارسی کے بہت اچھے اور لائق معلم تھے۔ اس زمانے میں مولانا شبلی متکلم ندوی مدرسۃ الاصلاح سرائمیر کے مہتمم تھے، وہ علامہ شبلیؒ کے تلمیذ رشید اور اس مجلس اخوان الصفاء کے ایک رکن تھے جو علامہ مرحوم کی وفات کے بعد ان کے ناتمام کاموں کی تکمیل کے لیے مولانا حمیدالدین فراہیؒ کی سربراہی میں قائم ہوئی تھی۔ مولانا شبلی متکلم معقولات اور اسرار شریعت کی کتابوں کا درس اس شان سے دیتے تھے کہ طلبہ کو مطالب بخوبی ذہن نشین ہوجاتے تھے۔ مدرسہ کا معیارِ تعلیم بلند اور بہتر بنانے کے لیے ان کو دوبارہ مدرسہ کی خدمت کی زحمت دی گئی تو بڑھاپے میں بھی ان کے درس کا وہی رنگ رہا، اس کی شہادت مولانا نجم الدین صاحب نے اس طرح دی کہ وہ چپکے سے جنگلے کے پاس جاکر درس سنا کرتے تھے۔ ان کے علاوہ مولانا عبدالرحمن نگرامی ندوی، مولانا حکیم محمد لہراوی اور دوسرے اساتذہ سے بھی درسیات کی تکمیل کی، ۱۹۱۷؁ء میں جب مولانا حمیدالدین فراہیؒ دارالعلوم حیدرآباد کی پرنسپلی سے استعفا دے کر مدرسۃ الاصلاح...

المؤيدون لدعوة تحرير المرأة

Modern Arabic literature particularly short stories and essays deal with, among others, liberation of women from outdated and oppressive traditions. There are supporters of this trend and also opponents to this attitude in Arabic prose. This article touches the issue of women 's liberation in Arabic literature produced in Egypt during thefirst half of the twentieth century. The major subject-matters included therein are veil, adornments, polygamy, marriage, divorce, women’s joining workforce, and free-mixing of both male andfemale.

Linear and Nonlinear Landau Damping With Non-Maxwellian Distribution Function

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