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Home > Identification of Gl13 Gene Polymorphism in Polydactyly Patients from Bahawal Nagar District of Pakistan

Identification of Gl13 Gene Polymorphism in Polydactyly Patients from Bahawal Nagar District of Pakistan

Thesis Info

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Author

Imran Nawaz Bhatti

Institute

Virtual University of Pakistan

Institute Type

Public

City

Lahore

Province

Punjab

Country

Pakistan

Thesis Completing Year

2018

Thesis Completion Status

Completed

Subject

Software Engineering

Language

English

Link

http://vspace.vu.edu.pk/detail.aspx?id=227

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676721000044

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GLI3 gene is a well-known transcriptional repressor, majorly involved in developing the digits. As it is the promising gene for the digit development so recently many research is in process for exposure of potential application of this gene. The rapid increase of polydactylism in humans has led to more interest on the study of this gene from researcher and scholars. In this study we had taken the blood samples of 50 individuals including different families were collected, age ranges of the patients were from 3-75 years, and had symptoms from moderate to severe from different areas of District Bahawalnagar. Physical sings were used as the selection criteria. 3.5-4ml venous blood was drawn and stored into 50ml tube containing 400?l EDTA, labeled with code number. The results obtained through different characterization e.g. (inorganic method, DNA estimation, sequencing of PCR product and electrophoresis) for GLI3 gene exon 14. Thermo-cycler programs for the amplification of primers were not show any mutation in premier exons. Gel was visualized and in trans-illuminator and hence to ensure the amplified product. No further mutation has been observed in DNA strand. The DNA strands shows similar behavior of GLI3 exon 14 for effected and normal individual. The mutation in this specified GLI3 gene is not responsible for polydactylism. Therefore, GLI3 gene is not accountable for any mutation caused polydactylism in an individual.
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بے ایمانی دی سزا

پرانے وقتاں دی گل اے کہ اک پہاڑ دے دامن وچ اک شخص رہندا سی۔ اوس کول بہت ساریاں مجھاں گاواں سن۔ مجھاں گاواں سارا دن ادھر اُدھر چر دیاں۔ شام نوں تھوڑی دیر پہلاں اوہ ددھ چوندا۔ اوس وچ بہت سارا پانی ملاندا تے کول دے شہر وچ جا کے ویچ آندا۔ اوہ ہر اک گاہک نوں آکھدا کہ ددھ خالص اے۔ ددھ ویچ کے ضروریاتِ زندگی دیاں چیزاں خرید دا تے گھر واپس آ جاندا۔

گاہک اوس نوں اکثر شکایت کردے کہ ددھ بہت پتلا اے۔ ایس وچ پانی نہ ملایا کر۔ کسے وی شکایت دا اوس اتے کوئی اثر نہ ہوندا۔ سگوں آکھدا کہ ددھ وچ پانی ہونا قدرتی امر اے۔ میں پانی نہیں ملاندا نالے ددھ کیہڑا سکا ہوندا اے۔ ایس طرح ددھ ویچدے اوس نوں بہت عرصہ گزر گیا۔ ہن اوہدے کول بہت زیادہ دولت وی آ گئی سی۔ اوہ کسے نوں کجھ وی نئیں سی سمجھدا۔ دن بدن لالچ ودھدا گیا تے اوہ ددھ وچ پانی دی مقدار وچ وادھا کرداگیا۔

اک دن اچانک اسمان اتے کالی بدلی اُٹھی تے اوس پورے اسمان نوں اپنے کلاوے وچ لے لیا۔ ہر طرف ہنیرا ای ہنیرا ہو گیا۔ اوہ بہت خوش ہویا کہ مینہ پوے گا۔ جس پاروں گھاہ زیادہ ہووے گا۔ گاواں مجھاں کھا کے زیادہ ددھ دیون گئیاں۔ بس فیر میرے وارے نیارے ہو جاون گے۔ اچانک بدل گرجیا۔ بجلی چمکی پہلاں ہولی تے فیر تیز بارش شروع ہو گئی۔ ایس دے نال اولے پین لگ پئے۔ ہر پاسے پانی ای پانی ہو گیا۔ پہاڑاں توں پانی سیلاب دی صورت وچ ایس شدت نال اوہدے پنڈ ول ودھیا کہ اوہدیاں گاواں مجھاں، گھر تے گھر دا سارا سامان اپنے نال بہہ کے لے گیا۔ ہن اوہدے کول نہ تے گاواں مجھاں سن تے نہ ای گھرتے نہ نقدی، اوہ...

Introducing an Unexplored South Asian Treatise on I‘jāz Al-Qur’an

The present paper explores and introduces a manuscript on i‘jaz al-Qur’ān (inimitability of the Qur’ān) named Nūr al- Īqān bi i‘jaz al-Qur’ān written by a profound South Asian Sindhi Scholar, Maulana Muhammad Ismā‘īl al-Ūdvī. The field of i‘jaz al-Qur’ān has been and is the field of interest of many Muslim as well as non-Muslim theologians and scholars. Many Muslim scholars of the Middle East and the West have written books and research papers from third/ninth Century up to present times. The main and significant reason for this is that the doctrine of i‘jaz al- Qur’ān proves the prophecy of Prophet Muhammad peace be upon him. This paper argues that Shaikh al-Ūdvī is the first South Asian Sindhi Muslim Scholar, who wrote a separate treatise in Arabic on the doctrine of i‘jaz al-Qur’ān, which is not introduced properly in academic circles of the day. In this treatise, al-Ūdvī has advanced some new and original arguments to support the doctrine and the prophecy of Prophet Muhammad peace be upon him.

Effect of Home and Institution on the Development of English Language Skills in Southern Areas of Khyber Pakhtunkhwa.

The study aims to find out the effect of home and institution on the development of English language skills in Southern areas of Khyber Pakhtunkhwa i.e.to find out the attitude of the pupils towards basic language skills (reading and writing), to find out the effect of the Social Economic Status (SES) of the students on their language skills (reading and writing), to observe the effect of instructional strategies of English teachers regarding in the development of basic English language skills (reading and writing), to check the effect of co- curricular activities on the basic English languages skills (reading and writing).The population of the current study was 29945 9th class studentsof 606 secondarymale and female schools of southern areas. The sample of the study were 12 teachers and 379 students of secondary schools which were taken through Krejcie and Morgan rule (1970). Various research tools were used in this study included, a five point likert type attitude scale, socio economic status scale, an observation sheet, a checklist, tests in reading and writing English skills. All these tools were made valid and reliable before its administration. Research questions and hypotheses were developed in line with the objectives of the study the data of attitude scale was analyzed through percentage, data received from socio economic status was analyzed through mean, the data received from checklist was analyzed by using percentage and rank order, the data collected from observational sheet was analyzed by using chi square, t test and ANOVA were used for differentiating between the values of means of reading and writing scores of students across the locality and divisions respectively. The study concluded that dismal situation of English reading and writing skills of the students in southern areas is due to weak supportive environment of home and institution. The role of home and institution was found significant for improving reading and writing skills in English, and the study recommends both community link and institutional environment need to be made more rich/conducive for English language learning.