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Home > Association Analysis of Ar Gene Polymorphism With Androgenetic Alopecia

Association Analysis of Ar Gene Polymorphism With Androgenetic Alopecia

Thesis Info

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Author

Sadia Kousar

Institute

Virtual University of Pakistan

Institute Type

Public

City

Lahore

Province

Punjab

Country

Pakistan

Thesis Completing Year

2018

Thesis Completion Status

Completed

Subject

Software Engineering

Language

English

Link

http://vspace.vu.edu.pk/detail.aspx?id=237

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676721003114

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Alopecia is a genetic disorder characterized by distinct forms of baldness. Main reason of alopecia is the imbalance between hair fall and regrowth. Alopecia has two broad types syndromic alopecia which occur along with other clinical conditions like epilepsy, nail dystrophy etc. Non syndromic alopecia does not show any extra clinical conditions. Androgenetic alopecia is commonly known as male pattern baldness. 80% of males above age of 70s and 80s are affected by this condition. In Asian general population approximately 73% instances of disorder has been reported. High level of circulating androgens which are actually steroid hormones are possible cause of male pattern baldness as scalp hair follicles show sensitivity for these circulating androgens. This association between androgens and male pattern baldness make androgen receptor gene as a promising candidate to check the pathogeneses of androgenetic alopecia. The rs6152 a single nucleotide polymorphism in exon 1 of AR gene has been reported in association with androgenetic alopecia. This study will check the association of mention polymorphism with AGA in random Pakistani male population.
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