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Home > Association Study Between Vitamin D Receptor Gene Apai Polymorphism and Osteoporosis in Population of Lahore

Association Study Between Vitamin D Receptor Gene Apai Polymorphism and Osteoporosis in Population of Lahore

Thesis Info

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Author

Rifat Shafi

Institute

Virtual University of Pakistan

Institute Type

Public

City

Lahore

Province

Punjab

Country

Pakistan

Thesis Completing Year

2019

Thesis Completion Status

Completed

Subject

Software Engineering

Language

English

Link

http://vspace.vu.edu.pk/detail.aspx?id=341

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676721027856

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Osteoporosis is known as a chronic and systemic bone disorders. Osteoporosis xiv destroys the bone microarchitecture tissues thus bone becomes so weak that leads the high risk of fractures. Mostly women are affected than men. Osteoporosis and its related fractures has become serious problem in Pakistani elder population and according to survey the prevalence of osteoporosis in our country is 9.9 million and 7.2 million out of them are osteoporotic women. Genes of Vitamin D receptor (VDR) consider as candidate gene for bone mass regulation in osteoporosis. The current study examined the VDR gene polymorphism (ApaI) on PCR-RFLP based on hundred samples among the population of Lahore, city of Pakistan to determine prevalence of osteoporosis and compare the frequency of osteoporosis between genotype and allelic sub-groups. The analysis showed that the single nucleotide polymorphism (SNP) followed HardyWeinberg equilibrium (HWE) that p > 0.05. No significant association was found among case and controls for allelic and genotypic frequency. The case and controls both have almost same frequency of AA, AC and CC genotype. Almost same allelic (A and C) frequency of ApaI also demonstrated no significant association among case and controls. Therefore it was observed that ApaI polymorphic site on VDR gene has no significance relation for osteoporosis in studied patients (p> 0.05). The current study recommended that ApaI VDR genotype could not be candidate gene leading to osteoporosis. The current study is also tried to uncover its associated risk factors that Phosphorus has significance association (p =.006) with normal?and patient (by an independent-sample t-test) hence it has also significant association (p =.026) with age groups (by ANOVA). It means that phosphorus has key function for bones development and bone strength
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Foreword One

The Qur’an is a Message that encompasses the essence of all the previous Divine Revelations since the beginning of time, and it will ring true till the end of time. The process of Divine Guidance was initiated with the inauguration of human existence on the earth and Prophet Muhammad (peace be upon him) was the last Messenger to be the savior of humanity, signaling the end of Divine Revelations and the Prophethood.

 

It may not be unfair to consider all former Divine Revelations a prologue for the Qur’an and all former Prophets being sent to prepare us for the arrival of Muhammad - the Seal and Gem of a Prophet - peace be upon him.

 

Millions of pages have been written to make the words of the Qur’an easily comprehensible by societies by and large in order to facilitate the use of The Book and the lessons it contains in all its wisdom and help humanity in the application of its lessons and verdicts to the capricious conditions of life.

 

In being the ultimate miracle of Allah – the Exalted and Merciful - and the abiding evidence of Allah’s Grace and Mercy, it unfolds the realities of the past and also miraculously guides human thought and action.

 

Its Message transcends the boundaries of space and time and will enter eschatological stages with mankind as a manifestation of Divine Communication with humanity.

 

It is a difficult task to bring about a comprehensive explanation of the Qur’an: an endeavor that has been a challenge for Muslim scholars since the time Shah Wali Allah first...

تعزیرات پاکستان میں سزائے موت سے متعلقہ دفعات کا شرعی قوانین سے تقابلی جائزہ

Law plays a pivotal role in the establishment of any peaceful society. Islam, being proactive, devised important rules about 1400 years back for the safety of Deen, life, wealth, wisdom and Generation. Qatal (murder) is a crime of taking soul of a humanbeing, about which Islam has announced Qisas i.e to do with assissinater what he has done it to killed human being. In the same manner Pakistan penal Code has gathered rules about crimes steped out in Pakistan. So Pakistan penal code, under several sections has the same punishment. This artcle throws light on Pakistan penal code sections about death Senctance in perspective of Islamic imperium, order and explanation.

Synthesis of Metal Halide Perovskite Materials for Light Harvesting Applications

The work described here deals with the synthesis and characterization of inorganic and hybrid perovskite for light harvesting applications. The inorganic lead and copper based metal halide perovskites were prepared and their fluorescent sensing ability was explored. The all-inorganic bulk CsCuCl3 and CsCuBr3 perovskites were synthesized by wet chemical method and were used for sensing of lead ions and aqueous contamination in DMF respectively. On the other hand, aerosol assisted chemical vapour deposition (AACVD) technique was adopted to fabricate thin films of CsPbBr2I. The oleylamine capping agent facilitates the formation of morphological controlled microsquares on the glass substrate. In addition, nanosquares of CsPbBr2I perovskite were prepared by wet chemical approach. Furthermore, phase pure micro sized crystals of CsPbBr2I were obtained by using TOP as antisolvent as well as capping agent to control morphology of microcrystals. These microcrystals were then used for nitrophenol detection. The CsPbBr2I bulk perovskite were used to fabricate ZnO based planner solar cell which have shown promising power conversion efficiency of 4.8%. The as-prepared metal halide perovskite were characterized by powdered X-ray diffraction spectroscopy (pXRD), UV-Visible spectroscopy (UV-Vis), photoluminescence spectroscopy (PL), thermogravimetric analysis (TGA), field emission scanning electron microscopy (FESEM) and transmission electron microscopy (TEM). In addition, thermal and water stable OHNH3PbX3 hybrid perovskites were prepared for photocatalysis application to degrade dye molecules. Whereas, the synthesis of (Cs)x(PhNH3)2-xPbBr4-xIx perovskite nanoparticles were performed to develop qusai-2D structures. The replacement of B site cations to develop lead free CH3NH3Pb1-xCuxBr3 hybrid perovskites was described. The gradual replacement of lead with copper leads to the formation of lead free hybrid perovskite nanoparticles and thin film. These hybrid perovskites have shown interesting optical properties.