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Investigation of Antidiabetic Potential of Parthenium Hysterophorus Carrot Grass on Alloxan Induced Diabetic Rabbits

Thesis Info

Access Option

External Link

Author

Munazza Makhdoom

Institute

Virtual University of Pakistan

Institute Type

Public

City

Lahore

Province

Punjab

Country

Pakistan

Thesis Completing Year

2019

Thesis Completion Status

Completed

Subject

Software Engineering

Language

English

Link

http://vspace.vu.edu.pk/detail.aspx?id=371

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676721036507

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Parthenium hysterophorus is of great medicinal importance. It has been used to cure fever, malaria, diarrhea, dysentery, and neurologic disorders. It also has anticancer agents as well. This study evaluates the antidiabetic effects of methanolic extract of all plant parts of Parthenium hysterophorus in diabetic rabbits (alloxan-induced). Twenty-five rabbits were divided into 5 groups (N=5). The group I served as a standard control. Groups II to V were injected with freshly prepared alloxan solution 150mg/kg intraperitoneally to induce diabetes. Glucose levels were checked to ensure hyperglycemia (diabetes). Group II till V received these treatments. Group II: Alloxan 150mg/kg alone; group III: Alloxan + MEPH (50mg/kg); group IV: Alloxan +100mg/kg MEPH (100mg/kg); group V: Alloxan +Glucophage (62.5mg/kg) respectively for a period of 10 days orally via feeding cannula. The safety assessment of these extracts was carried out in rabbits by oral administration with 50mg/kg, 100mg/kg& 150mg/kg body weight daily for7 days. They remained normal at the dose of 50g/kg, 100g/kg whereas, they showed anxiety in their behavior at high dose i.e., 150mg/kg. Changes in the body weight of all animals were recorded on day 1 , 7 st th 4 th and 10 and 10 th days. Short term (1 st , 3 rd , 5 th and7 th hour) and long term (4 th , 7 th th day) hypoglycemic effect were recorded using easy glucometer C 20. All animals were sacrificed on 10 day to isolate the pancreas for histopathological examination. The results showed that Parthenium hysterophorus L. lowers the blood glucose level in all the groups of alloxan-induced diabetic rabbits. However, the swift reduction in blood glucose level with MEPH was comparatively less than the experimental standard drug i.e., Glucophage.The Pancreatic histopathological studies depicted that a high dose of MEPH administration repaired alloxan-induced pancreatic damage. Whereas, Glucophage only reduced blood glucose level as no repair in damaged tissue was observed in the histopathological study of Glucophage treated animals. The study shows that the whole plant of Parthenium hysterophorus L. is very useful for developing effective phytomedicine to treat diabetes mellitus. The present investigation recommends the use of Parthenium hysterophorus as an herbal remedy for diabetes
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کچھ غیر رسمی باتیں

کچھ غیر رسمی باتیں
ابتدائے کلام کرتا ہوں

دم تری بندگی کا بھرتا ہوں
جب تری حمد کان پڑتی ہے

دلِ مردہ میں جان پڑتی ہے
کیونکہ
ہے نکتہء آغازِ سخن نام اسی کا
میں سب سے پہلے خدائے بزرگ و برتر کی بلند بارگاہ میں سجدہ ریز ہوں جس نے مجھے عقل و شعور بخشا اور فہم و فراست سے نوازا۔الحمدللہ رب العالمین علی کل حال!۔بعد از حمد و ثناء مقصودِ کائنات فخرِ موجودات شفیعِ اعظم حضرت احمد مجتبیٰ محمد مصطفیٰؐکی بارگاہ میں دست بستہ بے حساب درو و سلام کہ جن کا امتی ہونے کی خواہش انبیاء کرام علیہم السلام نے فرمائی۔
خدائے بزرگ و برتر کا بے حساب شکر گزار ہوں کہ جس نے اپنی رحمت سے مجھے زندگی کے اس سفر کو عبور کرنے کی صلاحیت عطا فرمائی۔حمد و ثناء اور درود و سلام کے بعد سب سے پہلے شکر گزار ہوں اپنی امی جان کا جو کہ میری پہلی استاد ہیں اور جنہوں نے میرا ہاتھ پکڑ کر لکھنا سکھایا۔اپنے والد محترم کا شکر گزار ہوں کہ جنہوں نے خود تنگیاں اور پریشانیاں خندہ پیشانی سے برداشت کیں اور ہمیں ہر سہولت اور آسائش فراہم کی اور مجھے ہر چند روز بعد میرے مقالے کی بابت پوچھتے رہے کہ’’ بیٹا کتنا کام کر لیا اور کتنا رہتا ہے‘‘۔اس سے مجھے بروقت کام کرنے میں تحریک ملتی رہی۔میں اپنی دادی جان کا بھی بے حد شکر گزار ہوں جن کی بدولت میرے اندر ادبی ذوق پیدا ہوا۔اپنی دونوں بہنوں کا بھی دل سے شکر گزار ہوں جنہوں نے مقالہ لکھنے کے دوران میری ہر ضرورت کا خیال رکھا اور میری ایک آواز پہ لبیک کہا۔میں اپنے شاگردِ رشیدمحمد خلیل اور چھوٹے بھائی محمد دانش ملک کا بھی شکریہ ادا کرتا ہوں جنہوں نے کلامِ یونس...

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Degradation of Selected Pesticides Using Fentons Reaction Based Advanced Oxidation Processes

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