Search or add a thesis

Advanced Search (Beta)
Home > Investigation of Antidiabetic Potential of Parthenium Hysterophorus Carrot Grass on Alloxan Induced Diabetic Rabbits

Investigation of Antidiabetic Potential of Parthenium Hysterophorus Carrot Grass on Alloxan Induced Diabetic Rabbits

Thesis Info

Access Option

External Link

Author

Munazza Makhdoom

Institute

Virtual University of Pakistan

Institute Type

Public

City

Lahore

Province

Punjab

Country

Pakistan

Thesis Completing Year

2019

Thesis Completion Status

Completed

Subject

Software Engineering

Language

English

Link

http://vspace.vu.edu.pk/detail.aspx?id=371

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676721036507

Asian Research Index Whatsapp Chanel
Asian Research Index Whatsapp Chanel

Join our Whatsapp Channel to get regular updates.

Similar


Parthenium hysterophorus is of great medicinal importance. It has been used to cure fever, malaria, diarrhea, dysentery, and neurologic disorders. It also has anticancer agents as well. This study evaluates the antidiabetic effects of methanolic extract of all plant parts of Parthenium hysterophorus in diabetic rabbits (alloxan-induced). Twenty-five rabbits were divided into 5 groups (N=5). The group I served as a standard control. Groups II to V were injected with freshly prepared alloxan solution 150mg/kg intraperitoneally to induce diabetes. Glucose levels were checked to ensure hyperglycemia (diabetes). Group II till V received these treatments. Group II: Alloxan 150mg/kg alone; group III: Alloxan + MEPH (50mg/kg); group IV: Alloxan +100mg/kg MEPH (100mg/kg); group V: Alloxan +Glucophage (62.5mg/kg) respectively for a period of 10 days orally via feeding cannula. The safety assessment of these extracts was carried out in rabbits by oral administration with 50mg/kg, 100mg/kg& 150mg/kg body weight daily for7 days. They remained normal at the dose of 50g/kg, 100g/kg whereas, they showed anxiety in their behavior at high dose i.e., 150mg/kg. Changes in the body weight of all animals were recorded on day 1 , 7 st th 4 th and 10 and 10 th days. Short term (1 st , 3 rd , 5 th and7 th hour) and long term (4 th , 7 th th day) hypoglycemic effect were recorded using easy glucometer C 20. All animals were sacrificed on 10 day to isolate the pancreas for histopathological examination. The results showed that Parthenium hysterophorus L. lowers the blood glucose level in all the groups of alloxan-induced diabetic rabbits. However, the swift reduction in blood glucose level with MEPH was comparatively less than the experimental standard drug i.e., Glucophage.The Pancreatic histopathological studies depicted that a high dose of MEPH administration repaired alloxan-induced pancreatic damage. Whereas, Glucophage only reduced blood glucose level as no repair in damaged tissue was observed in the histopathological study of Glucophage treated animals. The study shows that the whole plant of Parthenium hysterophorus L. is very useful for developing effective phytomedicine to treat diabetes mellitus. The present investigation recommends the use of Parthenium hysterophorus as an herbal remedy for diabetes
Loading...
Loading...

Similar Books

Loading...

Similar Chapters

Loading...

Similar News

Loading...

Similar Articles

Loading...

Similar Article Headings

Loading...

مولانا اکرام اﷲ خان ندوی

مولانا اکرام اﷲ خان ندوی
افسوس ہے کہ گذشتہ مہینہ ہندوستان اور پاکستان کے کئی اصحاب ِ علم وقلم نے وفات پائی، ان میں سب سے ممتاز شخصیت مولانا اکرام اﷲ خان ندوی کی تھی، مرحوم دارالعلوم ندوۃ العلمأ کے دورِ اول کی پیداوار اور اپنی علمی وتصنیفی قابلیت کے اعتبار سے ممتاز حیثیت کے مالک تھے، ان کا وطن شاہجہان پور تھا، اور تعلیم ندوۃ العلمأ میں حاصل کی تھی، انھوں نے مولانا شبلی مرحوم سے باقاعدہ درس تو نہیں لیا تھا، مگر ان کی صحبت کے فیض یافتہ تھے، تعلیم سے فراغت کے بعد کئی سال تک دارالعلوم کے مشہور رسالہ الندوہ کے اڈیٹر رہے، اور کچھ دنوں تک ندوہ کے اہتمام کے فرائض بھی انجام دیئے تھے۔
غالباً ۱۹۲۰؁ء میں نواب صدر یارجنگ مولانا حبیب الرحمن خان شروانی مرحوم نے اُن کو آل انڈیا مسلم ایجو کیشنل کانفرنس کے اسسٹنٹ سکر یٹری کی حیثیت سے علی گڑھ بلالیا تھا، جس سے وہ آخر عمر تک وابستہ رہے، مولانا شروانی مرحوم کا قیام امور مذہبی کی صدارت کے سلسلہ میں حیدر آباد میں رہتا تھا، اس لئے کانفرنس کا سارا کام مولانا اکرام اﷲ خان کے ہا تھوں میں تھا، جس کو انھوں نے بڑی خوش اسلوبی سے چلایا، کا نفرنس گزٹ کے اڈیٹر ی کے فرائض بھی وہی انجام دیتے رہے، اور کانفرنس کی تجویزیں اور سالانہ اجلاسوں کی رپورٹیں وغیرہ بھی وہی مرتب کرتے تھے، اور ۱۹۲۰؁ء سے لے کر ۱۹۵۱؁ء کامل ۳۰ سال تک کانفرنس انہی کی ذات سے عبارت تھی مرحوم کو ندوۃ العلمأ سے بھی گہرا تعلق تھا، اور وہ ہر زمانہ میں اسکی خدمت انجام دیتے رہے۔
طبعاً نہایت متین، خاموش، کم آمیز اور دنیاوی جاہ وشہرت سے بے نیاز تھے، اسی لئے علمی دنیا میں وہ شہرت حاصل نہ کرسکے، جس کے وہ حقیقتاً مستحق تھے، مگر...

ENVY A PSYCHOLOGICAL DISORDER: AN ISLAMIC PERSPECTIVE

A negative feeling that creates displeasure and anger is known as envy. It is produced by the negative attitude towards others, having assets, greater characteristics and fair potential than him. It is a psychological disorder that creates a nuisance in society and leads to social discontent. Such kind of psychological disorder gives rise to hatred and creates an environment of enmity and mistrust. Its magnitude and impact are very high and result in conflicts and jealousy. Such a situation is disliked in Islam and is taken very seriously and rejected at all levels. It is a mental disorder that disturbs the human psyche at local and international levels, resulting in chaos and disorder. Islam guides its followers in particular but humans, in general, to remain away from it to save humanity from anarchy and psychological sickness. Islam respects humanity and guides us to preserve human dignity and values of life. It prescribes detailed solutions to such a problem to preserve human beings. In this paper, an attempt is made and a detailed analysis is provided about its occurrence within the Islamic context and methods of safety are provided to safeguard humans from the malice of envy.

Bioconversion of Plant Feedstock to Fermentable Saccharides

Bioconversion of different pre-treated agricultural feed stocks into saccharides was carried out using thermophilic cellulases. Agricultural by-products i.e. sugarcane bagasse, wheat and rice straw were subjected to acid and alkali at steaming temperatures, auto-hydrolysis and microwave pre-treatments. Auto-hydrolysed and alkali pre-treated substrates showed better delignification i.e. 86.01% (wheat straw), 77.84% (sugarcane bagasse), 67.23% (rice straw) vs. 84.11% (wheat straw), 73.90% (sugarcane bagasse), 68.47% (rice straw), respectively. These de-lignified substrates were analyzed for total phenolic content (TPC) which were subsequently removed by washing with distilled water, extraction by organic solvents and detoxification by calcium hydroxide. Minimum residual TPC was observed in auto-hydrolysed substrates using calcium hydroxide i.e. 52 mg gallic acid equivalent (GAE) per g of dry weight (DW) of substrate in wheat straw, 59 mg GAE/g DW in sugarcane bagasse and 54 mg GAE/g DW in rice straw. The surface area i.e. 4 and 2mm granule size of all auto-hydrolysed substrates was assessed for saccharification potential and granule size of 2mm was found best with saccharification of 11.01% (sugarcane bagasse), 9.34% (wheat straw) and 4.36% (rice straw). Saccharification of auto-hydrolysed substrates using simultaneous addition of cellulases gave maximum saccharification in wheat straw i.e. 22.93% after 5 h of incubation at 80°C employing sodium citrate buffer of pH 6.5. Cellulase concentration of Endo-1,4-β-glucanase (125 U), Exo-1,4-β-glucanase (150 U) and β-1,4- Glucosidase (50 U) was optimized for 2% of wheat straw yielding 36.78% saccharification. Sequential addition of cellulases showed an improved saccharification of 55.64% employing Endo- 1,4-β-glucanase (75 U), Exo-1,4-β-glucanase (100 U) and β-1,4-glucosidase (50U) after 5.5 h of incubation. Scale up of the sequential saccharification in a 50 L reaction vessel resulted in increased saccharification of 57.91% with decreased time of incubation (3.5 h). In addition, substrate concentration of 2.5 % with agitation of 100 rpm was optimized with consequent saccharification of 62.12%. After saccharification, the hydrolysate was analyzed for TPC which were removed using activated charcoal. Minimum TPC i.e. 64.43 mg GAE/mL of liquid phase was achieved using 3% activated charcoal at 40°C after 20 min of incubation. The hydrolysate was analyzed by thin layer chromatography and found to have glucose and cellobiose. Wheat straw before auto-hydrolysis, after auto- hydrolysis and enzymatic breakdown was assessed for structural variance by scanning electron microscopy.