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Home > Molecular Analysis of Gnrh1 Gene Sequence in Infertile Male Patients

Molecular Analysis of Gnrh1 Gene Sequence in Infertile Male Patients

Thesis Info

Access Option

External Link

Author

Haleema Zafar

Institute

Virtual University of Pakistan

Institute Type

Public

City

Lahore

Province

Punjab

Country

Pakistan

Thesis Completing Year

2019

Thesis Completion Status

Completed

Subject

Software Engineering

Language

English

Link

http://vspace.vu.edu.pk/detail.aspx?id=373

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676721036949

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There are various causes of human male infertility and various genes might be involved. Gene under study for present research work was GNRH1 (Gonadotropin Releasing Hormone 1). For this study 40 samples of males with abnormal semen analysis report were collected from different diagnostic centers with informed consent. Then DNA was extracted. Primers were designed for GNRH1 gene and amplified through PCR. Sequencing was outsourced and bioinformatics tools were applied to analyze the sequenced data. There were 14 variations at different positions identified in this study in GNRH1 gene. Variations observed at position c.1325+40 and c.1325+181 mentioned in literature as rs2709608 but predicted that it has no significant effect on protein, whereas rs1453947741 have not been cited in any research article till date which is associated with deletion of A at position c.1325-144. It is potential target site and shows significant change affecting splicing. No data has been found which state the disease causing variations of diagnosed positions in my study. The study concluded that GNRH1 gene has certain variations and splicing might have effect on intronic variations which result in diseased condition and might have role in association with human male infertility.
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62. Al-Jumu'ah/The Congregation

 

62. Al-Jumu'ah/The Congregation

I/We begin by the Blessed Name of Allah

The Immensely Merciful to all, The Infinitely Compassionate to everyone.

62:01
a. Whatever is within the celestial realm and the terrestrial world is Glorifying Allah – The One and Only God -
b. The Sovereign, The Holy, The Almighty, The All-Wise.

62:02
a. It is HE WHO assigned among the people who had no Scripture a Messenger – Muhammad ibn Abdallah - from among themselves
- to recite HIS Messages from The Qur’an to them, and
- to purify them spiritually from dogma, myth, and polytheism, and
- to teach them of the Law, and
- the wisdom - morality and beliefs, etc.
b. Though before this, they were clearly astray from the Divine Guidance.

62:03
a. And also HE assigned Muhammad to others from them who have not joined them as yet.
b. And HE is The Almighty, The All-Wise.

62:04
a. Such is the Grace of Allah, which HE confers upon whoever HE Wants.
b. And, HIS Grace, HE has now conferred upon The Last of the Prophets, Muhammad,
c. for Allah is the Possessor of Infinite Grace.

62:05
a. The likeness of those who had been charged with enacting and complying with laws of The Torah, then did not uphold it, is as the likeliness of a donkey carrying a load of books oblivious of benefiting from them.
b. How evil is the likeness of the people who deny and belie Allah’s Messages in The Torah and now in The Qur’an!
c. And Allah does not guide the people who have chosen to be misguided and are wrongdoers.

...

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