The study was designed to confirm the diagnosis of Fanconi Anemia patients by MMC induced
chromosomal breakage studies along with the related clinical characteristics at cytogenetic
laboratory of Armed Forces Institute of Pathology, Rawalpindi. Out of 192 patients included in
the study, 24 had confirmed diagnosis of Fanconi anemia. Amongst which 14 (58.33%) were
male and 10 (41.66 %) were female patients. The mean age calculated for this disease in our
study is 11.18 years. These patients presented with phenotypic features like hyperpigmented spots
on skin, microcephaly, short stature or thumb/radial anomalies. Many suffered from aplastic
anemia while some had pancytopenia, thrombocytopenia or less frequently prevalent bone
marrow disorders. Major characteristics noted in the present study were the anomalies related to
weight, height and skeleton. Leukemia or Myelodysplastic syndrome was also present in some of
the cases. Moreover, they had other clinical history of bruises, infections, bleeding gum and fever
etc. Around 30-50% of the metaphases showed breakages in the chromosomes of these after
being subjected to clastogenic stress by mitomycin C. The cytogenetic analysis pattern of
Fanconi anemia is like the international studies. At present, the technique mentioned in our study
using the mitomycin C (MMC) induced chromosome instability is the gold standard test for the
timely diagnosis of Fanconi anemia as clinical features cannot confirm the diagnosis alone. With
the use of DNA cross linking clastogenic chemicals such as Mitomycin-C (MMC); the diagnosis
and timely confirmation of this disease can be done when patients presented with related signs
and symptoms. Early diagnosis of this disorder is very important as this would help in efficient
treatment of patients before the disease starts showing further life-threatening complications.
Knowing the karyotype pattern of Fanconi anemia can also help in genetic counseling of the
patients and their families. Also, wide-scale national community-based survey with Fanconi
anemia registry could help in estimating the size of the problem in our country more accurately as
previously no such work has been done or available in the literatures.
مولانا شوکت علی ہندوستان کی اسلامی دنیا گزشتہ مہینہ ایک اور صدمۂ عظیم سے دوچار ہوئی، یہ مولانا شوکت علی صاحب کی ناگہانی موت کا سانحہ ہے، یہ وہ شخصیت ہے جس نے تیس برس تک مسلمانوں کی خدمت کی، وہ نہ عالم تھے، نہ مقرر تھے، وہ جیسا کہ خود کہا کرتے تھے سپاہی تھے، ان تھک کام کرنے والے، نڈر، پردل اور پرامید، وہ کبھی کسی حال میں ناامید نہیں ہوتے تھے، ان کی تقریر چند فقروں کی ہوتی تھی، مگر وہ فقرے لوگوں میں روح پھونک دیتے تھے، وہ اپنے ساتھیوں کو بھی کبھی مایوس نہیں ہونے دیتے تھے، یہ انہیں کا کام تھا کہ ۱۹۲۰ء سے مرتے دم تک سارے ہندوستان کو چھان مارا تھا، تیس برس کی جانکاہ محنت کے بعد موت نے سپاہی کی کمر کھول دی اور وہ ابدی آرام کے لئے دائمی نیند سوگیا، جامع مسجد دلّی کی سیڑھیاں ان کی خواب گاہ بنیں چشم اعتبار اس کے لوح مزار پر یہ شعر کندہ پائے گی: زباں دانِ محبّت بودہ ام دیگر نمید انم ہمی دانم کہ گوش ازدوست پیغامے شنید اینجا حزیں ازپائے رہ پیمابسے سرگشتگی دیدم سر شوریدہ بربالین آسائش رسید اینجا میری ان کی سب سے پہلی ملاقات ۱۹۱۲ء میں ہوئی، بنگلور میں اسلامی تعلیمی کانفرنس تھی، وہ لکھنؤ کی سمت سے اور مجھے مولانا شبلی مرحوم نے بمبئی سے بھیجا تھا، ہم دونوں کا ساتھ اس گاڑی میں ہوگیا، جو دونوں سمتوں کے مسافروں کو لے کر بنگلور جاتی تھی، رات کا وقت تھا، وہ اس زمانہ میں نوکری سے الگ آغا خان کے سیکریٹری کی حیثیت سے مسلم یونیورسٹی کے لئے چندہ جمع کررہے تھے، وہ پہلے بھی صاحب تھے اور اس وقت بھی پورے صاحب تھے۔ اس وقت ایک واقعہ یاد آگیا، تھوڑی دیر کی گفتگو کے بعد میں نے عشاء کی نماز...
Āisha bint Abdu Al-Rahmān (1913-1998), better known by her pen nickname ‘Bint Ash-Shātī’, was one of the 20th-century Egyptian exegetes (mufassirīn) of the Qur'ān who implemented the methodological approach to the interpretation of the Qur'ān introduced by her teacher, mentor and husband Amīn alKhawlī, an eminent Egyptian scholar of the Qur'ān who contributed to the Qur'ānic sciences from several important aspects. Bint Ash-Shātī continued the legacy of her teacher and published a number of works related to the discipline of the Qur'ānic sciences such as al-Tafsīr al-Bayānī li al-Qur'ān alKarīm and al-I’jāz al- Bayānī li al- Qur'ān wa Masā’īl Ibn alAzraq. She made an attempt to examine all the previous Qur'ānic exegeses. Though Bint Ash-Shātī benefited from the classical tafsīr literature in her writings, she made several critiques on the classical tafsīr literature. Because of her scholarly approach, she became a famous Qur'ānic scholar in her life and even she was awarded the King Faisal Award, the most prestigious award in the Muslim world, in 1993 for her intellectual contributions. This paper attempts to analyze the methodological approach adopted by Bint Ash-Shātī in her works on Qur'ānic studies.
Unwise use of herbicides has resulted in environmental and health problems not only for human beings and also for animals but it also caused some weed species to dominate fields due to resistance development against herbicides. Among the alternate ways of weed management in field crops application of allelopathy has shown tremendous scope in agricultural pest management. Different sowing methods and planting times has varying impact on the associated weeds. Studies on dynamics of weed flora and its management by allelopathy in wheat at varying sowing times planted by different methods were conducted at the Agronomic Research Area, Department of Agronomy, University of Agriculture, Faisalabad, Pakistan during 2008-09 and 2009-10. In the first experiment, weed flora under different sowing methods and planting dates was investigated. In second experiment allelopathic plant water extracts (PWE) of sorghum, sunflower and mulberry in combination with reduced doses of a herbicide in different sowing methods was evaluated. Whereas in third experiment, plant water extracts used in the second experiment in combination with reduced doses of a herbicide under different planting methods were assessed. Weed flora mainly consisted of Chenopodium album L. and Phalaris minor L., while few plants of Fumaria parviflora L., Avena fatua L., and Anagallis arvenses L. were also observed. It is noted that weeds if not controlled, can cause 60-66% yield losses in wheat. Maximum wheat productivity and net returns were obtained from wheat sown at November 15 on beds. Allelopathic PWE in combination with 1/3 rd dose of herbicide provided as effective weed control as was achieved from label dose of herbicide during 2008-09 and 2009-10 which caused substantial yield increase (54%), suggesting that herbicide dose could be reduced by 67%. For achieving eco-friendly weed control and maximum productivity allelopathic PWE combined with 1/3 rd dose of herbicide could be applied in wheat planted on beds at November 15.