Birth Ordinal and Trust on Close Interpersonal Relationship: A Comparative Study of First and Last Born Individuals

The objective of this study was to investigate the differences in the level of trust in close interpersonal relationships among first born and last-born individuals. The sample of the present study was comprised of 120 participants (first born=60; last born=60). Data was collected through purposive random sampling. The age range of the participants in the present study was 20-45 years and both genders were given equal representation. Trust level of the participants was measured through Trust in close interpersonal relationship scale. Personal Information Questionnaire was also used to gather the information about the characteristics of participants such as age, birth ordinal, gender, education etc. It was hypothesized that there would be significant differences in the trust level of first born and last born. Findings revealed significant differences in the trust level of first born and last-born participants. Last born participants have more trust in interpersonal relationship. Gender differences were also found in the trust level. Females have more trust than males. The implications of the study have discussed in terms of child-rearing practices.

Design, Synthesis, Characterization and Anti-Inflammatory Studies of Oxa and Thiazole Scaffolds

Inflammatory diseases are associated with a number of ailments; these disorders could be life threatening like hepatitis, cancer, trauma injury while some decreases the quality of life such as rheumatism, arthritis, tuberculosis etc. Oxa and thiazoles, having unparalleled share in pharmacological activity of especially anti-inflammatory, have arisen as superb templates in drug discovery. Their unique attributes have instigated synthetic chemists to access their innovative analogues by efficient and viable strategies. Insightful insertion of other heterocyclic cores, bicyclic rings and other active functionalities at appropriate sites has greatly enhanced their diversified bioactivities. This research endeavor is made to synthesize some novel anti-inflammatory agents based on oxa/thiazole via green protocol. Hence synthesis of new derivatives of oxa and thiazoles by novel routes focusing green strategy such as DES mediated preparation were carried out by adopting Hantzsch approach. For this purpose, ketones containing simple alkyl to pretentious alkyl functionalities such as tetrahydrocarbazoles and aryl moieties like phenyl and coumarin were used. Besides this, novel amide and thioamide analogues were also synthesized by functionalizing established bioactive heterocycles at their N position and the second step is annulation of these analogous with a series of bioactive ketones. A series of novel oxa and thiazoles each comprising twenty one compounds were synthesized. All new molecules were screened for in vitro anti-inflammatory potential by HRBC membrane stabilization method. Precursors were also subjected to antiinflammatory screening and only those were employed for the synthesis of oxazole and thiazoles which were found comparatively potent. N N NH 2 X R 1 O CH3 N N X R 1 N H X N R 1 N Oxa/ thiazoles N H R H X 2N N R H X 2N Green / Conv. Precursors Characterization of all of the innovative derivatives was done by analytical techniques like FTIR, 1HNMR and MS and CHNS analyser. Compounds 110, 111, 113d, 113b, 113g, 114a, 114b, 114c, 114f, 115b, 115e, 115f, 116d, 117b, 117c, 118a, 118b were found to possess best anti-inflammatory activity.