جناب محمد طفیل
ادھر گذشہ تین مہینے میں اس برصغیر میں چار موتیں ہوئیں جن سے علمی حلقے کو بڑا صدمہ پہنچا، ان کی یادیں برابر آتی رہیں گی۔جناب محمد طفیل اڈیٹر نقوش لاہور اپنے کسی کام سے اسلام آباد آئے، رات کو خوش خوش سوئے تو اپنی میٹھی نیند ہی میں ۵؍ جولائی ۱۹۸۶ء کو اﷲ کو پیارے ہوئے، اور اپنے بے شمار قدردانوں کو سوگوار چھوڑ گئے، انھوں نے نقوش کو اپنی ادارت میں ایک علمی فیکٹری بنا رکھا تھا، جس طرح کسی فیکٹری سے مشینیں ڈھل کر نکلتی ہیں، اسی طرح نقوش سے طرح طرح کے علمی و ادبی نمبر نکلتے رہے، غزل نمبر، افسانہ نمبر، مکاتیب نمبر، خطوط نمبر، شخصیات نمبر، طنز و مزاح نمبر، منٹو نمبر، بہ طرس نمبر، لاہور نمبر، آپ بیتی نمبر، ادب آلعالیہ نمبر، ادبی معرکہ نمبر، غالب نمبر، میرتقی میر نمبر، شوکت تھانوی نمبر، میر انیس نمبر اور اقبال نمبر کے علاوہ آخر میں تیرہ جلدوں میں رسول نمبر نکالا، اور قرآن نمبر نکالنے کی فکر میں تھے کہ خود وہاں پہنچ گئے جہاں سے یہ مقدس صحیفہ نازل ہوا تھا۔
یہ سارے نمبر علمی، ادبی اور تاریخی، انسائیکلوپیڈیا بن گئے ہیں، اس لحاظ سے وہ خوش نصیب تھے کہ ان کا خاتمہ بالخیر رسول نمبر پر ہوا، اس کی تیرہ (۱۳) جلدیں دینی فیوض اور ملی برکات کا سرچشمہ بنی رہیں گی، یہ بیسویں صدی میں اردو زبان کا ایسا شاندار کارنامہ ہے جو مدت مدید تک یاد رکھا جائے گا، وہ اپنی دنیاوی زندگی میں لوگوں کو علمی کوثر، ادبی تسنیم اور دینی سلسبیل کے جام پر جام پلاتے رہے، دعا ہے کہ اب جہاں وہ پہنچ گئے ہیں وہاں برکت اخروی کی کوثر، مغفرت الٰہی کی تسنیم اور رحمت ایزدی کے سلسبیل سے سیراب ہوتے رہیں، آمین، وہ اپنے پیچھے یہ درس چھوڑ گئے ہیں...
Adultery, immorality and sexual misconduct is a major crime, which has been condemned in all previous legislations sent by Allah, ancient nations, the bedouin tribes and in Islamic law. The religion of Islam not only forbids adultery, rather it prohibits going even near the causes leading to it. From medicinal point of view, adultery may cause AIDS, herpes etc. The word “zina” means to have sexual relationship without a marriage contract. Its synonyms in Arabic are: al bigha, al safah, al anat, and al fahisha. Islam imposes punishment on unmarried people committing adultery. According to Imam al shaf’i, the punishment is one hundred lashes for both man and the woman, and exile for one year. Whereas Imam Abu Hanifa only imposes one hundred lashes. For a married adulterer, the punishment is hundred lashes and death by stoning. Rest of the jurists unanimously agree that they will only be stoned to death. Majority of the scholars agree that if a concubine commits adultery, she will be giving fifty lashes. According to Saeed bin Musayyib, she will be beaten in order to teach her decent manners. In order to impose the punishment of zina on someone, it will be ensured that the adulterer is an adult, the woman should not be from a country who is at war with the Muslims, she is alive and the adultery has taken place in a Muslim country. Among the the repulsive results of adultery are spread of sexually transmitted diseases, increase in number of illegitimate children, lesser percentage of legitimate children and increase in crimes. One of the factors pointing towards the prohibition of zina is that it has been forbidden since early Islam and a severe punishment has been imposed on it. Of the vices of zina is the mixing up of lineages. Our society today is flooded with immoral behaviour, which is endangering our “iman” and “yaqeen” and is driving our society towards destruction. This wave of immorality has reached the elite of the society and it is obligatory upon every individual to put his share in stopping it.
Three new series of ligands (derived from amino acids) have been synthesized from view point of their structural and biological studies. The first series belongs to amide derivatives of amino acids (A1-A9), second belongs to urea derivatives of amino acids (A10-A18) and the third one belongs to thiourea derivatives of amino acids (A19-A30). Tributyltin(IV) and bismuth(III) derivatives of these ligands have also been prepared in good yields by refluxing the respective ligand with bismuth(III) chloride or tributyltin(IV) chloride in presence of potassium hydroxide in appropriate stoichiometric ratios in dry methanol as solvent. The structure of the synthesized compounds were characterized by elemental analysis, ICP-OES, FT-IR, multinuclear (1H, 13C, 119Sn) NMR spectroscopy and single crystal X-ray diffraction. Based on these results, the synthesis of ligands have been confirmed and the data also suggested that these ligands appeared to coordinate the bismuth and tin centers through the oxygen of carboxylate moiety. The tributyltin(IV) derivatives mostly demonstrate tetrahedral geometry both in solid and solution state. Whereas octahedral geometry was proposed for bismuth(III) complexes both in solid and solution state based on single crystal X-ray analysis, FT-IR and NMR spectroscopy respectively. Finally the biological activity tests such as anti-bacterial, anti-fungal, anti-oxidant, enzyme inhibition and lethality bioassays for majority of the synthesized ligands were carried out and found some encouraging results. All of the synthesized compounds were evaluated for their potential as anti-bacterial and anti-fungal agents against different strains of bacteria and fungi. Both of the tributyltin(IV) and bismuth(III) complexes have shown good to significant anti-bacterial and anti-fungal properties and some of them were found to be more potent than standard drugs available in markeet. It was observed that tributyltin(IV) complexes have shown slightly better activities than bismuth(III) complexes. These results propose that these compounds may be utilized as anti-bacterial and anti-fungal agents in future in the wake of following the medication improvement methodologies. Anti-oxidant potential of these newly synthesized compounds was also evaluated and some of them exhibited significant anti-oxidant activity. viii These compounds were also examined for their α-glucosidase inhibition, urease inhibition and lipoxygenase inhibition activity and some of the compounds showed excellent results in inhibiting these enzymes, even more than the standard drugs. Some compounds from all the series were tested for anti-tubercular activity and show poor activity. They were also assayed for their brine shrimp lethality test and data suggests that the compounds show low toxicity. However the data pertaining to bioassay tests for all the synthesized compounds exhibiting some encouraging results and may be trialed further in drug discovering processes to find out the lead compounds by modifying/altering their structural motifs.