حکیم صدیق احمد امروہوی ثم بریلوی
مئی کے اسی ہفتہ میں ایک اورحادثہ یہ پیش آیا کہ ہمارے نہایت عزیز اور مخلص دوست اوراپنے فن کے ماہرحکیم صدیق احمد صاحب امروہوی ثم بریلوی نے وفات پائی۔عمرغالباًپچھتر چھہتر برس ہوگی۔اصل وطن امروہہ ضلع مرادآباد تھا، مگر ایک عرصۂ دراز سے بریلی میں مقیم تھے۔ ان کے والد ماجد مولانا حکیم مختار احمد صاحب ایک نہایت حاذق طبیب ہونے کے علاوہ پختہ استعداد کے عالم باعمل، متقی اور عابد و زاہد بزر گ تھے۔ حکیم صدیق احمد کی بھی علوم وفنون میں استعداد بڑی پختہ تھی، شروع میں منطق اورفلسفہ کا بڑاغلبہ رہا۔نہایت ذہین اور طباع تھے۔اس لیے کوئی موضوع بحث ہو تقریر مدلل اورمنطقیانہ کرتے تھے۔ حضرت شاہ عبدالقادر صاحب رائے پوری سے بیعت ہونے کے علاوہ اعمال و وظائف کا ورد کثرت سے کرنے لگے تھے۔فن طب میں نظری اورعملی مہارت و حذاقت انھیں ورثہ میں ملی تھی، طبیعت بے حد رساتھی۔تشخیص اورتجویز دونوں میں ان کی شہرت دور دور تک تھی۔ سینکڑوں بڑے معرکے کے علاج کئے لیکن وہ جتنے بڑے طبیب تھے، اسی قدر مزاج سخت لاابالی اورروپیہ پیسہ کے لالچ سے کوسوں دورتھے۔ غریبوں اور ضرورت مندوں کی امداد اپنی جیب سے کرتے تھے اورعلما کی خدمت کرکے خوش ہوتے تھے، غرض کہ بڑی خوبیوں اورکمالات کے انسان تھے۔اُن کے پاس مخطوطات کاایک خاصہ ذخیرہ تھا جس میں حضرت مولانا محمد قاسم صاحب نانوتوی اوربعض دوسرے بزرگوں کے مکاتیب اور ان کی تحریریں شامل ہیں۔لیکن راقم الحروف کے سخت اصرار کے باوجود انھوں نے ان چیزوں کو نہ خود چھاپا اورنہ کسی اورکو انھیں نقل کرنے کی اجازت دی۔پھر معلوم نہیں ان کا کیا حشر ہوا۔
اخلاق وعادات کے اعتبار سے نہایت خلیق،خوش طبع و خوش مزاج اور متواضع و مہمان نواز تھے۔رحمہ اﷲ رحمۃً واسعۃً۔ [جون۱۹۷۸ء]
Macro approach in the national education is both organization empowering and education process. Education excuting organization has coverage and autonomous that it can accommodate society need in every situation. The education process is carried out openly to inlarge inputs from society. The education process is carried out by instilling a sense of excellence to face global challenges, while at the same time trying to make educational institutions the center of civilization. All that requires educational innovation that focuses on curriculum renewal, teaching materials, evaluation systems, building repairs and construction, etc. Teachers as education personnel have a central role in administering an education system. By becoming a teacher, someone expects to be able to obtain adequate compensation for the necessities of life. In motivation theory, the provision of appropriate rewards and punishments, can affect the performance and quality of work.
Copper(I) halide complexes with N,Nʹ-disubstituted thioureas and triphenylphosphine have been synthesized by the reaction of halotris(triphenylphosphine)copper(I) and respective thioureas (121) at 60 °C. The newly synthesized complexes were fully characterized by various instrumental techniques like FT-IR, multinuclear (1H, 13C, 19F, 31P) NMR spectroscopy while elemental analyses were carried out using a CHNS analyzer and atomic absorption spectroscopy. Some of the copper(I)-N,Nʹ-disubstituted thiourea complexes (A3, A7, A9, A16, B1, B3, B4, B6, B13, B14, B18, B19, C1, C3, C8, C9, C10, C12, C14, and C15) were analyzed via single crystal XRD for structural elucidation. From single crystal XRD it has been identified that copper(I) adopted distorted tetrahedral geometry in coordination with sulphur (substituted thiourea), two phosphorus (triphenylphosphine) and halogen. Most of the complexes were stabilized by intramolecular hydrogen bonding. The synthesized complexes were screened for cytotoxicity (Brine shrimp), antibacterial, antifungal, antileishmanial, antioxidant and DNA binding studies. In Brine shrimp lethality assay complexes B17 and B11 were the most active with LC50 of 19.6 µg mL–1 and 20.1 µg mL–1, respectively. In case of antibacterial activities, in the chlorinated series (A), the most active complex against E. Aerogens was A15, against B. Bronchiseptaca it was A12 and against S. Typhimurium were A9 and A3 with ZOI value comparable to that of the reference commercial drug. Similarly, in the iodinated series (C), the most active complex against B. Bronchiseptaca was C13 and against S. Typhimurium it was C9 with ZOI values of 20±1.46 and 19±1.27 mm, respectively. Against A. fumagatus(Fungi) the most active complex was B14 with a ZOI value of 19.5±1.46 mm which was comparable to that of the reference value. In Leishmanicidal activity all the test samples were active against L. tropica with LC50 values in the range of 20 to 50 µg mL–1. In the assay of DPPH Free-Radical Scavenging, all the test samples were significantly active toward DPPH and the antioxidant activity of the complexes was found within the range of 54.96-62.67%. From UV-vis spectroscopy and molecular docking studies it has also been observed that copper(I) tetrahedral complexes interact strongly with the DNA via a groove binding mode. From molecular docking the highest value of Kb was found to be 1.08×105 for A12 which is attributed to the intra-strand cross linking of benzo[d]thiazol-2-yl of thiourea in the complex with DA17 and DT6 base pairs of DNA in addition to groove binding interactions.