حرمت۔ لفظ زمانے کو بتانے کے لیے
میں تو آیا ہوں یہاں شعر سنانے کے لیے
ایک دریا ہے کہ الٹا ہی بہے جاتا ہے
ایک کشتی کو مصیبت سے بچانے کے لیے
تم انہیں رونق۔ بازار بنا لائے ہو
خواب ہوتے ہیں زمانے سے چھپانے کے لیے
یہ درختوں کی قطاریں، یہ ستاروں کا ہجوم
مجھ کو رکنا ہے یہاں چاند بنانے کے لیے
لوگ تخریب کو تعمیر سمجھ بیٹھے ہیں
بس یہی بات ہی کافی ہے رلانے کے لیے
ہم نے لے دے کے یہی ایک محبت کی ہے
آئے دنیا میں تھے ہم نام کمانے کے لیے
میرے کچھ دوست ، تو ایسے ہیں خدا کی توبہ
بات کرتے ہیں، مگر آگ لگانے کے لیے
دل کے اعصاب پہ چھائے ہوئے اچھے موسم!
تو، تو آیا ہے مجھے چھوڑ کے جانے کے لیے
میرے ہونٹوں پہ ہمیشہ یہ سوال آتا ہے
بستیاں کون بساتا ہے جلانے کے لیے ؟
مجھ سے پوچھو ، کہ شب و روز ترستا ہوں سعید
دل کی حالت کسے اپنے کو سنانے کے لیے
After reading the whole books and find out the interpretation, there were various sayings, the meanings and interpretations of the verses of Quran. The reader does not have the capability to select correct and incorrect. He does not know what to do about the various interpretations. At first the people of Mecca knew the status of Revelation; they do not need to explain that revelation, because it was their native language while the Prophet (S.A.W) explains it in detail. After the earlier periods, it was necessary to adapt some rules to know the correct sayings, that rules were already include the Quran itself, in the Sunnah, in the Quranic Sciences, in the books of fundamentals of Jurisprudence, and in the books of Quranic Sciences. Later on, however, wrote the books as contemporary independent science as such as book of Husain Al Ḥarbī named (قواعد الترجيح عند المفسرين) and book written by Khalid Al Sabbath named (قواعد التفسير جمعاً ودراسةً). These rules of preference are most important as with the help of these rules, the books of interpretation can be clarified from incorrect sayings. These rules are various, including, related to Quranic text, Sunnah, the views of Companions, the evidence, or related to the linguistics of Arabs. The preference proves the strength of a saying or strengthens an aspect than others through rules of preference. One of the objectives of this research is that the rules of preference can distinguish between correct and incorrect interpretation. The researcher recommended attention to these rules of preference and to study it as a separate subject to get full benefit from the books of interpretation.
Cancer, also known as neoplasia, involves uncontrolled cell proliferation leading to malignant tumor formation. Epithelial cancers (or carcinomas, representing about 80% of all cancers) are a group of cancers originating in the epithelial lining of many locations, such as digestive tract, airways, breast, reproductive tracts and oral cavity. Oral cancer is one of the eight most common types of cancer worldwide. It starts from the upper digestive tract, including the larynx, oral and nasal cavities. Whereas lung cancer is the major cause of cancer-related deaths worldwide, representing about 26% to 28% per year. Heavy alcohol consumption, betel nut chewing, smoking, viral infections, occupation hazard and exposure to UV radiation are the major risk factors. Tyrosine kinase receptors (TKs), such as EGFR and Lyn are major regulators of cell growth and survival. In cancer cells, such receptors are constitutively activated and lead to malignant phenotype. Blocking of active TKs efficiently stops proliferation and induces apoptosis in oral and lung cancer cells. In the present study, we selected five TKIs (Genistein, Gefitinib, Erlotinib, Dasatinib, and Imatinib) which acts upon EGFR and Src family tyrosine kinases. Imatinib and Dasatinib are non-optimal TKIs for oral and lung carcinomas, and have to be utilized at relatively high concentrations to display inhibition. Our goal was to select therapeutically suitable small molecules, such as resveratrol (a natural polyphenol) and artemisinin along with its derivatives (synthetic endoperoxides) to potentiate the sub-optimal activity of standard TKIs. The objective of our study was to investigate standard TKIs and the possible adjuvant effects of artemisinin derivatives (endoperoxides, EPs) and resveratrol (natural phenol, NP) on highly malignant lung cancer cells (NCI-H460) and laryngeal cancer cells (KCLB-SNU46) of lower malignancy. Optimal combinations of TKIs and EPs/NP that decrease the proliferative capacity of oral and lung cancer cell lines, and increase their apoptosis potential were thus investigated. The techniques employed were flowcytometry, spectrophotometry, SDS-PAGE and western blotting. Out of five TKIs, Imatinib and Dasatinib at higher concentration and on 48 hours incubation affected the oral cancer cell line (KCLBSNU46). However, the lung cancer cell line (NCI-H460) responded to Gefitinib as well as Imatinib and Dasatinib only after 48 hours. Artemisinin itself didn’t show any effect but its endoperoxide derivatives OD59 and OD66 showed potent anticancer activity (with very low IC50) in both cell lines when compared to that of the standard TKIs. Resveratrol showed no effect on oral cancer cells, but lung cancer cells did respond to high resveratrol concentrations. In combination studies, resveratrol and endoperoxides (OD66 and OD67) showed significant synergistic effects when combined with gefitinib and dasatinib at very low concentrations in both the cell lines. Furthermore it was confirmed that these synergistic combinations induced apoptosis by modulating the phosphorylation of the EGFR and Lyn tyrosine kinases. This study conclude that resistance phenomena in cancer cells can be modulated by combining sub-therapeutic doses of standard TKIs with least effective doses of natural and synthetic compounds. This approach can conveniently reduce the dosage as well as the cytotoxic effects of the clinically used TKIs on cancer patients.