اسلام کے اخلاقی اور اعتقادی نظام میں ماحولیاتی تحفظ

Just as the prophet  and messenger from Allah Ta’ala direct man towards the creator, it also regulates the relationships of human life and helps him to return to the nature of Allah Ta’ala, which invites man to find goodness, happiness and well-being in creatures. We invite all researchers and intellectuals to know the facts of heavenly laws and religions, especially the teachings of  “Islam”. Since Islam is the essence of all divine religions, it deals with human life in particular and the universe in general and the life of nature around it in great detail, just as Islam focuses on Human beings. In the same way animals, plants and inanimate objects are also looked after otherwise what is the meaning of talking about issues related to tree planting, agriculture, water and other natural environment.  Human distance and ignorance from the role of religions on environmental protection is an important cause of environmental pollution, protection and its elements to restore. The religious teachings and spiritual guidance of all heavenly religious regarding  environmental protection can play an important role in the protection can play an important role in the protection of the environment, so the cause of the  environmental crisis and the invasion of its resources is a departure from spirituality and religious instructions and materialism. For example, those materialistic countries that do not believe in religions are engaged in destroying the ecological elements. Just so that they can get material facilities. They have become involved in wars and conflicts all of which they have been exposed to environmental disasters are which has never been observed by humanity in the history due to which these countries are suffering from environmental crisis on a large scale due to which it has become difficult to live in these countries.

A Study on the Synthesis and Biological Evaluation of Some 3, 6-Disubstituted-1, 2, 4-Triazolo[3, 4-B]-1, 3, 4-Thiadiazoles and 2, 5-Disubstituted-1, 3, 4-Oxadiazoles

The 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles and 1,3,4-oxadiazoles are prominent biological agents used as a cure against a number of human ailments. The present work deals with the synthesis of 3,6-disubstituted-1,2,4-triazolo[3,4-b]-1,3,4- thiadiazoles and 2,5-disubstituted-1,3,4-oxadiazoles bearing adamantyl and aryl moieties. The synthesis of 3,6-disubstituted-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles was carried out starting from aryl carboxylic acids. On the other hand, 2,5-disubstituted-1,3,4-oxadiazoles were synthesized using two distinct routes starting from either aryl carboxylic acids or aryl nitriles. The structures of the synthesized compounds were confirmed by IR, 1 H- and 13 C-NMR, EIMS and XRD analysis. The target compounds were screened for their antitumor, antiviral, antibacterial and antifungal potential. Among the tested compounds, 3-(2-methylphenyl)-6-adamantyl- 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole (4a) and 3-(2-fluorophenyl)-6-adamantyl-1,2,4- triazolo[3,4-b]-1,3,4-thiadiazole (4d) exhibited prominent antiproliferative activity against human CD4 + T-cells containing an integrated HTLV-1 genome (MT-4) with CC 50 of 45 μM and 47 μM, respectively. These compounds were also found to be active against human acute T-lymphoblastic leukemia (CCRF-CEM) cell lines with CC 50 of 40 μM each. 3-(3-Methylphenyl)-6-adamantylmethyl-1,2,4-triazolo[3,4-b]- 1,3,4-thiadiazole (4n) showed moderate inhibition of HIV-1 and HIV-2 with EC 50 of >10.90 μg/mL, but no selectivity could be witnessed. Similarly, 3-(3-methylphenyl)- 6-adamantylmethyl-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole (5n) was found to be potent exhibiting moderate inhibition of HIV-1 and HIV-2 with EC 50 of >10.86 μg/mL. Furthermore, oxadiazole (9a) and 2-adamantyl-5-(2-(2-methylphenyl)-1,3-thiazol-4-yl)-1,3,4- 2-adamantyl-5-(2-(2-bromophenyl)-1,3-thiazol-4-yl)-1,3,4- oxadiazole (9j) showed significant inhibition of HIV-1 and HIV-2 with EC 50 of >10.50 μg/mL and >10.90 μg/mL, respectively. However, antibacterial and antifungal activities of all the compounds were found to be non-significant at non-toxic concentrations.