سیر گری اور ترمینل نمبر1
قاہرہ سے شرم الشیخ جانے کے لیے نیل نامی ہوائی کمپنی کے جہاز میں محمد علی نے میرے ساتھ سفر کرنا تھا جلد ہی ہم دونوں میں ذہنی ہم آہنگی پیدا ہوئی اور مصریوں کے بارے میں میری رائے اچھی بننے لگی ۔قاہرہ کے ائیر پورٹ کے ترمینل نمبر 1پر عجیب چہل پہل تھی ، بھانت بھانت کے لوگ ،بھانت بھانت کی بولیاں بولتے عجیب و غریب لباس زیب تن کیے جوق در جوق اس ترمینل کی انتظار میں ٹولیوں کی شکل میں بیٹھے تھے۔سرخ،کالے ،بھورے ،زرد جتنے انسانوں کے رنگ اس سے زیادہ بولیاں ۔مسافر نے کرنسی تبادلے کی دکان پر موجود ایک خوش گفتار مصری سے پوچھا کہ یہ لوگ کن کن علاقوں سے یہاں آتے ہیں اور اس ترمینل سے کس منزل کی طرف جا رہے ہیں؟۔جواب ملا کہ دنیا بھر سے آتے ہیں؟مگر زیادہ تر لوگ روس سے آتے ہیں ۔میرے استفسار پر کہ اس ترمینل میں رقوم کے تبادلے کی کتنی دکانیں ہیں،اس نے کہا چار ۔پوچھنے پر پتہ چلا کہ صرف ایک دکان پر روزانہ تقریباََایک لاکھ امریکی ڈالر مصری پائونڈ میں تبدیل ہوتے ہیں چار دکانوں پر یہ تبادلہ ماہانہ ایک کڑو ر بیس لاکھ تک ہوتا ہو گا یہ آمدنی صرف سیر گری سے حاصل ہو رہی ہے ۔اس ترمینل سے اسکندریہ اور شرم الشیخ کی طرف صرف ان جہازوں کو اڑان بھرنے کی اجازت تھی جو مصری عوام و حکومت کی ملکیت میں تھے اور جہازوں کے کرائے بھی ان سیاحوں نے ڈالر وں میں بھرنے ہوتے ہیں ۔
مسافر نے سال پہلے عصرِ حاضر کے ’’مہا گرو‘‘اور ’’استاذالاساتذہ ‘‘ Googleجس کے شاگرد قریہ قریہ ،کوچہ کوچہ ا ور یم بہ یم پائے جاتے ہیں ،سے پوچھا کہ انسان سیر گری پر سالانہ کتنا خرچ کرتا...
Upbringing of children is a significant job which is carried out at homes, day care centers, formal and informal schools or institutions. Proper and socially acceptable change in the behavior of young children is needed in every society as per the social, cultural, regional and religious requirements. Different viewpoints are expressed in this regard especially about the use of corporal punishment in upbringing of children. This viewpoint is supported by some people while opposed by other at the same time. Islamic and Bible literature also provides guidance on this subject. The current paper deals with the Corporal punishment of children from the Islamic, Bible and contemporary points of view. Keywords: Bible, Islam, Contemporary Era, Corporal Punishmen
Introduction: The World Health Organization defines infertility as the failure of achieving conception after one year of unprotected intercourse. Worldwide, approximately 15% of couples are affected by infertility and genetic anomalies account for 15-30% of male factor infertility. Nearly 15% of infertile males suffer from azoospermia in the form of obstructive azoospermia or non-obstructive spermatogenic failure. Polycystic Ovary Syndrome (PCOS) was contributing 6-10% infertility in female population. Environmental and genetic factors are involved. However; etiology of PCOS still remains debatable. Primary Ovarian Insufficiency (POI) or Premature Ovarian Failure (POF) affects 1- 2% of women, and is characterized by amenorrhea before the age of 40 years. POI is heritable in up to 30% of individuals. Methodology: The study presented in the dissertation describes clinical and genetic analysis of twelve Pakistani infertile families (A-L) exhibiting azoospermia, POF, PCOS, Y chromosome microdeletions and chromosomal aberrations. These families were collected from different districts of Khyber Pakhtunkhwa Pakistan. Informed consents were taken from all the participants. Results: In this study, we investigated four azoospermic families (A-D) by whole exome sequencing (WES) analysis. WES data analysis of family A with two males with obstructive azoospermia and two fertile members (mother and brother) revealed a novel nonsense variant c.2326C>T (p.R776X) in dominant X-linked ADGRG2. WES data analysis and Sanger sequencing of family B with one azoospermic male, one fertile brother and parents revealed a compound heterozygous variant in AFF4, including c.3319A>G (p.T1107A). In family C one proband and parents samples were subjected for WES analysis, but no pathogenic variants were identified. WES data analysis of family D with one infertile brother, one fertile brother and parents revealed a novel nonsense variant c.646G>A (p.G216R) in X-linked AR. In family E, WES was performed for four family members and seven potential variants were identified but Sanger sequencing failed to confirm any pathogenic variant. Family F has two daughters displaying primary amenorrhea, elevated LH/FSH levels, atrophic uteri, reduced ovarian reserves, and normal 46XX karyotypes. WES analysis of five family members (parents, two affected daughters and one unaffected daughter) revealed a novel frame shift variant (c.709delC, p.Leu237fs) in the luteinizing hormone/choriogonadotropin receptor (LHCGR) gene. PCOS Families G, H and I were investigated for pathogenic variants. SNP microarray and WES analysis failed to identify pathogenic variants in PCOS families. Family J showed Y chromosome microdeletions (AZFc) in two azoospermic brothers. Families K and L exhibited chromosomal aberrations; OX and XXY karyotypes in azoospermic members in families respectively. Conclusion: Four families revealed novel variants as the likely cause of infertility (ADGRG2, nonsense variant (c.2326C>T); AR nonsense variant (c.646G>A); AFF4 compound heterozygous (c.3319A>G); LHCGR, frame-shift variant (c.709delC). WES in four families (three PCOS one POF) families could not identify genetic causes in the coding region. One family exhibited “Y” chromosome microdeletion (AZFc region deletion) and two families were found with chromosomal aberrations (XXY and OX).