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Screening of GJB2 involved in non syndromic autosomal recessive deafness in selected families

Thesis Info

Author

Quratulain

Supervisor

Sumbul Khalid

Department

Department of Bioinformatics & Biotechnology

Program

MS

Institute

International Islamic University

Institute Type

Public

City

Islamabad

Province

Islamabad

Country

Pakistan

Thesis Completing Year

2015

Thesis Completion Status

Completed

Page

51

Subject

Bioinformatics & Biotechnology

Language

English

Other

MS 571.94 QUC

Added

2021-02-17 19:49:13

Modified

2023-01-06 19:20:37

ARI ID

1676722021848

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98. Al-Bayyinah/The Clear Evidence

98. Al-Bayyinah/The Clear Evidence

I/We begin by the Blessed Name of Allah

The Immensely Merciful to all, The Infinitely Compassionate to everyone.

98:01
a. Those who disbelieve from among the Followers of the Former Scriptures and the idol- worshipers,
b. will not give up their disbelief until a Clear Evidence was presented to them,

98:02
a. through a Messenger from Allah, reciting purified scripts, and

98:03
a. containing clear instructions for them.

98:04
a. Yet those who were given the former Scriptures did not challenge and become divided into factions until after this kind of Clear Evidence came to them.

98:05
a. Even though all they were commanded to:
- submit to Allah alone in awe, reverence, and worship,
- sincerely devote religion exclusively to HIM, being Haneef, and
- establish the Salat/Prayers and
- pay out Zakat/annual charity
b. for that is/are the parameters of a Religion – Right and Straight.

98:06
a. Indeed, those who continue to disbelieve – even after Clear Evidence has come to them
- from Followers of the Former Scriptures and the idol-worshipers will be in the Fire of Hell - there to remain - never to leave, never to die.
b. Those - they will be the worst of created beings.

98:07
a. However, those who believe and practice righteousness,
b. those - they will be the best of created beings.

Surah 98 * Al-Bayyinah 749

98:08
a. Their reward is going to be with their Rabb - The Lord:
b. Gardens of Perpetual Bliss - through which rivers/streams flow - to live therein forever,
never to leave, never...

ماحولیاتی آلودگی اور تعلیمات نبویﷺ

For the guidance of all human being and for resolving the problems Allah has told in Qur’an.  The environmental pollution is a major issue of our life, Allah has also fully guided for this regard too. There is mentioned in The Holy Quran about that. There are seven types of pollution are: Water pollution, Air pollution, Soil pollution, Thermal pollution, Radioactive pollution, Noise pollution, Light pollution. Environmental pollution has existed for centuries but only started to be significant in dub trial resolution. Pollution occurs when the natural environmental cannot destroy an element without creating harm or damage to itself. The elements involved are not produced by nature and the destroying process can vary from a few days to thousands of years. Though the first we should clean our self then our society will be cleaned and will not remain any kind of pollution. In this regard the Holly Quran is also telling us about the purification. There are two types of purification internal external. Internal purification to purity the soul form the effects of sins and act of disobedience though repenting sincerely form all sins and act of disobedience Purification of the heart from the fifth polytheism. External purification by removing of filth is by using pure water of the water for the removal of the for the worshiper's garment body and from the place of prayer. We must thin for this serious issue and have to reform our society from this important issue. In fort, we get rid from those absolutely in the right direction.

Studies on Germination Ecology, Phytotoxic Effects and Control of Rhynchosia Capitata Roth Dc in Mungbean.

Studies on dormancy, ecology, phytotoxic effects, competition and chemical control of Rhynchosia capitata (Roth) DC in mungbean (Vigna radiata (L.) Wilczek) were investigated in the laboratory experiments at Department of Agronomy, University of Agriculture, Faisalabad and under farmer’s field conditions. In laboratory experiments different treatments for breaking dormancy of R. capitata seeds were evaluated. Seeds were soaked in thiourea, KNO 3 , HCl, HNO 3 and H 2 SO 4 as well as scarified mechanically (sand paper). Results indicated that seeds of R. capitata show signs of physical dormancy that is mainly because of impermeability of their coat. Mechanical scarification, acid scarification (soaking of seeds in H 2 SO 4 for 60 and 80 and in HCl for 12 and 15 h) were very effective in breaking dormancy and promoting germination. Seed soaking in HNO 3 for 1 to 5 days showed little effect, while, various concentrations of thiourea and KNO 3 were ineffective in breaking seed dormancy of R. capitata. Germination response of R. capitata to environmental factors such as temperature, salt stress, drought stress, pH, light and seeding depth were also studied. Germination increased as the temperature increased from 25 o C and considerably reduced at 45 o C. Germination of R. capitata seeds was not influenced by presence or absence of light. Increase in salt stress, moisture stress and seed burial depth significantly decreased the seed germination of R. capitata. Seeds of R. capitata had ability to germinate over a wide range of pH (5-10). In seed burial trial, maximum seedling emergence of 93 % was recorded at 2 cm depth, and seedlings failed to emerge from a depth of 12 cm. In third laboratory experiment, allelopathic influence of R. capitata on germination and seedling growth of mungbean along with detection of the phytotoxic materials liable for this action were studied. Aqueous extracts of root, shoot, leaf, fruit and whole plant (5%) adversely affected germination and seedling growth of mungbean, but higher inhibition was seen with R. capitata leaf water extract. A linear decrease in the germination characteristics of mungbean was observed with the decrease in the concentration of leaf extract from 5% to 1%. The soil incorporated residues (1-4% w/w) of R. capitata stimulated the development of root and hypocotyl at low concentrations and inhibited their development at elevated concentrations. Rhynchosia capitata soil incorporated residues (4% w/w) significantly reduced the seedling vigour index of mungbean in addition to its significant effect on total germination. A noteworthy amount of water soluble phenolic acids were found in extracts of different plant parts of R. capitata. Total phenolic acids were greater in leaf extract compared to that of stem, fruit or root extracts. Two phenolic acids, vanillic acid and 4-(hydroxymethyl) benzoic acid were found in R. capitata leaf extract. Effect of different weed crop competition periods i.e. full season competition, weed crop competition for 3, 4, 5, 6, 7 weeks and zero competition were studied under field conditions on mungbean. The results showed that full season weed competition produced highest weed fresh and dry weight, maximum NPK contents (%) and NPK uptake, highest Fe, Mn, Na, Zn, Ca, Cu and Mg contents and micronutrients uptake by R. capitata in both the years of study. The maximum plant height, number of pods per plant, grain number per pod and 1000-grain weight of mungbean was recorded in weed free plots. Increase in competition period decreased above parameters of mungbean significantly. Increase in R. capitata competition period decreased the mungbean grain yield significantly. In 2011, the weed-free plots gave the highest grain yield of 1688.6 kg ha -1 followed by competition 3 weeks after planting with 1582.0 kg ha -1 of seed xxiyield. The full season R. capitata competition decreased the grain yield to 869.3 kg ha -1 . Similar trend was also observed during 2012. In second field experiment, the efficacy of herbicides namely pendimethalin + prometryn @ 875 g, 700 g and 525 g a.i ha -1 , S- metolachlor @ 1440 g a.i ha -1 and pendimethalin @ 825 g a.i ha -1 in controlling R. capitata was evaluated. All doses of the herbicides suppressed the dry biomass of R. capitata from 60 to 78% in 2010 and 2011. Pendimethalin+prometryn @ 875g a.i. ha -1 , recorded (74% in 2010 and 78% in 2011) maximum reduction in total weed dry weight. Among herbicide treatments, maximum grain yield was recorded with pendimethalin+prometryn @ 875 g a.i. ha -1 in both the years. Pendimethalin + prometryn @ 875 g a.i. ha -1 proved best treatments for effective control of R. capitata in mungbean and to get maximum economic benefits.