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Identification of hERG human ether a go go related gene mutations in Pakistani population a computational perspective

Thesis Info

Author

Faria Khalid

Supervisor

Asma Gul; Muhammad Ismail

Department

Department of Bioinformatics and Biotechnology

Program

MS

Institute

International Islamic University

Institute Type

Public

City

Islamabad

Province

Islamabad

Country

Pakistan

Thesis Completing Year

2016

Thesis Completion Status

Completed

Page

55

Subject

Bioinformatics & Biotechnology

Language

English

Other

MS 616.128 FAI

Added

2021-02-17 19:49:13

Modified

2023-02-17 21:08:06

ARI ID

1676722085899

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زندگی خدا کی نعمت ہے

زندگی خدا کی نعمت ہے
اس کائنات رنگ و بو میں جہاں نظر دوڑائیں اُس منعم حقیقی کی عطا کردہ نعمتوں کی فراوانی ہی فراوانی ہے۔ کہیں کھیت وکھلیان کشت ِزعفران کا نمونہ پیش کر رہے ہیں، کہیں گلستان و نخلستان جشنِ بہاراں کی آمد کی نوید جانفراسُنارہے ہیں ، کہیں دریا اور نہر یں جوئے نغمہ خواں کی صورت میں موجود ہیں، کہیں کوہستانی علاقوں میں موجود فلک بوس پہاڑ اور جبال شامخہ ناظرین کو ورطۂ حیرت میں ڈال رہے ہیں۔ یہ سب اللہ تعالیٰ کی نعمتیں ہیں جو مختلف شکلوں میں موجود ہیں۔ لیکن ان سب سے بڑھ کر جواللہ تعالیٰ کی عظیم نعمت ہے وہ زیست ہے، وہ حیات ہے، وہ زندگی ہے۔
زندگی ہے تو سب نعمتیں رعنائیاں بکھیرتی ہوئی نظر آتی ہیں، زندگی کے حیات بخش قطروں سے سیراب شخص ہی جملہ انعاماتِ ربّانی سے متمتع ہوسکتا ہے، زندہ شخص ہی بادِنسیم کے مسحور کن جھونکوں سے مسرور ہوسکتا ہے، زندگی ہی گلہائے گلستان ونخلستان کی حسن و زیبائش کا احساس دلاسکتی ہے، زندگی سے حرکت ہے، زندگی سے برکت ہے، زندگی سے عبادت ہے، زندگی سے عیادت ہے۔ انسان کا وجود، قوم کا وجود ، معاشرے کا وجود ملک و ملت کا وجود زندگی کا ہی مرہونِ منت ہے۔
زندگی کی حقیقی رعنائیوں سے فائدہ اٹھانے والے ذی فہم فراست لوگ آسمان علم و دانش پر آفتاب و ماہتاب بن کر چمکتے ہیں، وہ اس حقیقت کو بھی فراموش نہیں کرتے کہ یہ زندگی ہمارے پاس اللہ تعالیٰ کی دی ہوئی امانت ہے، ہم نے اس میں خیانت نہیں کرنی ہے، ہم نے اپنی زندگی کو اُسی راستے پر گامزن کرنا ہے جہاں خالق حقیقی کی منشاء و مراد ہے۔
قرآنِ پاک میں ارشادِ باری تعالیٰ ہے کہ ’’ ہم نے انسان کو اور جن کو صرف اس لیے پیدا کیا...

ظاہری و باطنی صفائی اور مسلم معاشرے کاتعامل سيرت طيبہ کی روشنی ميں

Islam is a belief that prefers purity who introduces cleanliness from birth to demise. In the faith of Islam, there are orders for cleanliness, from cleansing the human body to the lane, the community, and the whole nation. Even the fact that all human deeds of worship are subject to ablution emphasizes the significance of cleanliness. Cleanliness is a commendation of Allah and the Sunnah of the Holy Prophet (S.A.W). Cleanliness is the nourishment of spirituality. Islam is theology in qualities. All the codes and prerequisites of exact nature are present in Islam. Islam has stressed cleanliness. It has instructed us to embrace both outer and inner cleanliness. Because the external influences the interior. Physical soundness is obtained, which makes it effortless to acquire internal cleanliness. When the inner self is also cleansed, an individual becomes a servant of Allah, freed from spiritual contaminants and impurities.

Comparative Ecology of Two Mongoose Species Herpestes Javanicus and H. Edwardsii Inhabiting Pothwar Plateau

Two species of mongooses; small Indian mongoose (Herpestes javanicus) and the grey mongoose (H. edwardsii) occur in many parts of Pakistan including the Pothwar Plateau. They are diurnal, terrestrial carnivores playing their ecological role in controlling populations of snakes, rodents and insects. The current study investigated their distribution, vegetation analysis of their habitat, population, and diet composition in the Pothwar Plateau. Distribution of the two mongoose species was recorded through reconnaissance surveys of the study area, vegetation analysis was carried out by quantifying trees (Point-Centered-Quarter method), shrubs and herbs (by Quadrate method). The populations of the two species were estimated by direct enumeration by minimum numbers alive (MNA) index using capture, mark, and recapture data and indirect enumeration, using active burrows (AB) count method. Diet composition of the two species was investigated by their scat analysis. The small Indian mongoose was found distributed in the vicinity of human dwellings, whereas, the grey mongoose was widely distributed in natural areas with low human activity, however, both species were found occupying the cultivated areas. Their distribution was found restricted below 850 m asl in the study area. Vegetation analysis of the habitat of two mongoose species showed Zizyphus mauritiana with high importance value index (IVI = 101.21) and Acacia nilotica (IVI = 95.13) as major tree species, Zizyphus nummularia (IVI = 90.29) as major shrub and 24 Cynodon dactylon (IVI = 20.70), Peganum harmala (IVI = 19.37) and Carthamus oxycantha (IVI = 18.24) as major herb species. burrows activity of both mongoose species was found highly associated with the Zizyphus mauritiana (50% and 46%, respectively). Average population density of small Indian mongoose was 7.91 ± 0.41 per km2 (by MNA) and 12.49 ± 0.4 per km2 (by AB method), whereas, that of grey mongoose was 7.17 ± 0.52 per km2 (by MNA) and 11.70 ± 0.33 per km2 (by AB method). Live trapped mongooses showed a sex ratio (M : F) of 0.73 (small Indian mongoose) and 0.78 (grey mongoose), indicating more female-biased population in the study area. Burrows depth and diameter as well as body measurements (body weight, body length and tail length) of the grey mongoose (n=72) were greater than those of the small Indian mongoose (n=72). Analysis of scat samples of the two mongoose species revealed hairs, feathers, insect body remains and plant matter and seeds along with some unidentified material. Identification of rodent prey species from recovered hairs showed that small Indian mongoose preys upon three different rodent species while the grey mongoose consumes five different rodent species in the study area. Insects consumed by both mongoose species belong to five different orders. Food niche breadth of the two species varied among different seasons of the year. Food niche overlap between the two species was found to be 0.95. The study concludes that the two sympatric mongoose species vary in their abundance along a gradient of human activity. Ecologically and morphologically, similar species (small Indian mongoose and grey mongoose) living in sympatry in the Pothwar Plateau partition their resources, though resources themselves may vary in time and space and in relation to extrinsic factors.