متوازن شخصیت: تعلیم و تربیت کا نبوی اصول

A child born with a soul of being, but has lack of personality. Actually personality comes with the effect of good education, guidance, squatter and environment in which a child lives. But literally due to the teachings of Hinduism or Buddhism or Christianity a human existence proves oneself with a personality. Even western civilization has an ideal concept of personality, but human personality has its very strong roots in Islamic teachings as Holy Qur’ān gives us a first-hand description about an “Ideal Personality”. According to the “Sunnah” of Prophet Muhammad (r) man has some qualities of “moderation” which can be the dominant in excess of his existence. So, man should establish equilibrium regards his personality. But there is need to create stability in education, society and politics on the basis of “moderation”. Islam lays a great emphasis on character building. Balanced personality is based on all the best qualities of head and heart. Our Holly Prophet’s (r) personality is an excellent example of balanced personality. In Islamic perspective just to accept the characteristics and Sunnah of Muhammad (r) can be equal to the modern word of personality. But have we absorbed the ultimate concept of personality? Which personality can we call an ideal personality? These two questions are very significant to wonder about on the concept of ideal personality. Every religion and civilization has its own true meaning of ideal personality, but besides all this according to Quran the ideal personality is concealed in a word “Sunnah”. The article highlights on basic characteristics of ideal personality in the light of teachings of Holly Prophet (r). Balanced and Moderate personality is the basic principle of Prophets Teachings

Identification of New Anti-Glaucoma Agents With Emphasis on the Inhibition of Carbonic Anhydrase Enzyme

Carbonic anhydrase is metal-containing enzyme that contains Zn and involves the carboxylation of water into carbonic acid, which normally converts into bicarbonate and protons Carbonic anhydrase inhibitors (CAIs) are utilized to lower the intraocular pressure (IOP) in glaucoma condition and also decrease the inflammation associated with increasing ocular hemodynamics, and ocular apoptosis. During the course of research period, a number of synthesized compounds were analyzed by bovine carbonic anhydrase-II (bCA-II) for development of new inhibitors. For this purpose high throughput biochemical mechanism based assay was employed for the identification of new inhibitors of CA-II enzyme. Spectra max-340 and M2 spectrophotometer from Molecular Devices (USA) were used to measure the inhibition potential through absorbance. Out of numerous classes of compound only schiff bases of triazole, tosylhydrazone (sulfonohydrazone), benzylidene and thiourea derivatives, were found to be good inhibitors of CA-II. The identified inhibitors were subjected to IC50 determination by serial dilution. The Ez-fit enzyme kinetics soft were employed to calculate the IC50 values from the % inhibition. The benzylidene derivatives exhibited. IC50 values in the range of 52.68 ? 0.47 to 348.57 ? 3.32 ?M. Schiff Bases of triazole derivatives have shown IC50 values between 98.23 ? 1.60 to 285.87 ? 2.67 ?M. While thiourea derivative exhibit excellent inhibition potential which illustrated IC50 values in the range of 1.90 ? 1.30 to 25.90 ? 2.05 ?M when compared with the standard inhibitor acetazolamide IC50 = 0.13 ? 0.05. Among all the compounds thiourea derivatives can serve as lead compounds for the identification of new inhibitors of CA-II.