Development and Evaluation of an Audio System Trainer

Guided by the desire to contribute a little in the development of an innovative instructional technology for the teaching of electronics, this researcher constructed a prototype audio system trainer. Electronics teachers will find the instructional tool convenient and practical to use for visual instruction, laboratory activities and troubleshooting works in electronics. To support the functionality of the audio system trainer, the researcher developed a supplementary laboratory manual. The project whose production costs totaled fourteen thousand two hundred seventy two pesos and fifty centavos (Php 14,272.50) was finished in two weeks’ time. However, this amount is small if compared to the prices of commercially available instructional device developed for the same purpose. The completed project and the supplementary laboratory exercises were evaluated by selected technical faculty members of the College of Industrial Technology of the Bulacan State University, Bulacan Polytechnic College, University of Rizal System, and Lyceum of the Philippines University. Sampling technique as used in the study is both purposive and incidental. The prototype audio system trainer received an over-all mean rating of 4.62 which means that the project is highly acceptable on a set of criteria which includes – physical features, cost, function / operations, and durability. Furthermore, the supplementary laboratory exercises obtained a mean of 4.70 which could be interpreted that the respondents strongly agree on the validity of the manual.

Chemical and Biological Evaluation of Medicinal Plants for Their Anti Carcinogenic Attributes

Cancer is terrible disease. It is second leading cause of mortality worldwide. Conventional cancer therapies burdened the disease crippled patient with toxic side effects and are also very expensive. Therefore, the demand to use alternative approaches in treatment of cancer is increasing. Plant derived compounds due to their unique structure and sophisticated mechanism of action play promising role in anticancer therapies. The main objective of current study was to evaluate anticancer potential of medicinal flora of Pakistan. The plants used in current study are frequently utilized in folk medicines for treatment of many ailments in Pakistan. In present research work these traditional medicinal plants were scientifically examined for their antioxidant, antitumor, antimicrobial, anticancer and anti-inflammatory potential. Furthermore, chemical composition of the plant extracts was evaluated by state of art chromatographic techniques such as UV/Vis spectrophotometer, HPLC and GC-MS, revealed the presence of phenolics, flavonoids and broad range of other bioactive components in them. Antioxidant activity was estimated by free radical scavenging activity estimated by DPPH (1,1- diphenyl 2-picrylhydrazyl) assay. The outcome of antimicrobial activity assay showed that E. coli was the resistant strain to most of tested plant extracts. Overall, among the fungal strains, A. niger was the sensitive one. Furthermore, we examined antitumor activity by potato disc assay. Chloroform extract of V. betnocifolia (IC50= 38.13 μg/mL) exhibited maximum antitumor activity. We determined anticancer activity of different plant extracts against human cancer cell lines (KBM, mylegeous leukemia; U266, multiple myeloma; SCC4, tongue squamous carcinoma and HCT116, colon carcinoma cells) by MTT assay. The extracts with maximum anticancer activity against human mylegeous leukemia (KBM5) cells were examined for inhibition of inflammatory transcription factor, nuclear factor kappa B (NF-kB). Surprisingly all the plant extracts inhibited TNF-α induced NF-kB activation.