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Analysis and characterization of CDHI/E-CADHERIN germiline mutations in breast caner a computational perspective

Thesis Info

Author

Faiza Munir

Supervisor

Sobia Tabassum; Abdul Hameed

Department

Department of Bioinformatics and Biotechnology

Program

MS

Institute

International Islamic University

Institute Type

Public

City

Islamabad

Province

Islamabad

Country

Pakistan

Thesis Completing Year

2016

Thesis Completion Status

Completed

Page

64

Subject

Bioinformatics & Biotechnology

Language

English

Other

MS 576.549 FAA

Added

2021-02-17 19:49:13

Modified

2023-01-06 19:20:37

ARI ID

1676722224336

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توفیق فاروقی

فاروقی، توفیق
بھائی توفیق فاروقی بھی اﷲ کو پیارے ہوگئے
موت توسب ہی کوآتی ہے اورآنی ہے ہی،جوچیز پیدا ہوئی ہے اسے فنا بھی ہونا ہے۔ موت بھی آنی ہے۔لیکن کچھ حضرات کی موت سے ایسا غم وصدمہ اور دکھ ہوتاہے کہ غم بھلانے سے بھی نہیں بھول پاتاہے۔
برہان میں وفیات کا صفحہ لکھاجاچکا تھا، شمیم عثمانی اور حضرت مولانا وحیدالزماں کیرانوی کے انتقال کی تعزیتی تحریر سپرد قلم کی جاچکی تھی کہ ابھی ابھی خبر ملی ہے کہ ’’خاتون مشرق ‘‘ اور ’’گلابی کرن‘‘ کے مدیر جناب توفیق فاروقی مورخہ ۲۴؍اپریل ۱۹۹۵ء بروز پیر کو عارضہ قلب میں مبتلا ہوکر انتقال فرماگئے ۔انا ﷲ وانا الیہ راجعون ۔
مرحوم توفیق فاروقی مجاہد آزادی مولانا عبداﷲ فاروقیؒ کے فرزند اکبر تھے، بڑے ہی ملنسار خلیق و متواضع اور یوپی ودہلی کی تہذیب ووضعداری کے نقیب و علمبردار تھے۔ انہوں نے ’’خاتون مشرق‘‘ اور ’’گلابی کرن‘‘ جیسے رسالوں کے ذریعے مشرقی خصوصاً مسلمان خاتون کو نیک وباعمل اورعفت وعصمت کاپیکر بنانے کا بڑا ہی اچھا اورقابل ستائش کام کیا۔
مفکر ملّت حضرت مفتی عتیق الرحمان عثمانیؒ سے مرحوم توفیق فاروقی اوران کے والد مرحوم مولانا عبداﷲ فاروقی نے ہمیشہ رہنمائی حاصل کی۔احقر عمیدالرحمن عثمانی سے بڑی محبت وعقیدت رکھتے تھے کہتے تھے کہ بھئی تم تو مجاہد ہوکہ اپنے ابّاجان اور ملّت کے رہبر مفتی صاحب کی یادگار ادارہ ندوۃ المصنفین اوررسالہ برہان کوقائم رکھاہوا ہے۔اﷲ تمہیں سلامت رکھے تمہارا دم بڑا غنیمت ہے۔
ذاتی معاملات میں مفتی صاحب کی وفات کے بعد بڑی مدد کی حمایت کی، بہرحال مرحوم توفیق فاروقی بڑے زندہ دل انسان تھے انہوں نے ادب و صحافت کی خدمت کی، ملک وملّت کی خدمت کی۔مسلمان عورت کواسلامی خاتون بنانے کے کاموں کوبڑی اچھی طرح انجام دیا۔اﷲ تعالیٰ غریق رحمت فرمائے اٰمین۔
ادارہ ندوۃ المصنفین اوررسالہ برہان کی طرف سے احقر عمید الرحمن...

استحکام خاندان میں زوجین کا کردار: سیرت طیبہ کا عملی و اطلاقی مطالعہ

In this universe, the most important relationship among the humans is marriage, other relations exist on the basis of this relationship. In the Holy Quran, the relationship of spouses has been mentioned as a source of mutual peace and love. In our society, it is said that women organize a home, but in reality a home can not be establish alone, spouses together make and adorn it with painstaking efforts. Man plays pivotal role in the relationship of spouses. So the responsibility of stability of the family lies on the man much more than the women and its reason is superiority. We find many examples from the marital life of our Prophet(S.A.W.W). This paper will highlight the teachings of Prophet Muhammad (S.A.W.W) about the role of spouses in the establishment of a family.

Effect of Anthropogenic Activities on Water Quality and Fish Fauna of Nullah Aik and Nullah Palkhu - Tributaries of River Chenab, Pakistan

Nullah Aik and Nullah Palkhu are major tributaries of River Chenab in Pakistan and important water resources in district Sialkot. These streams receive industrial effluents, municipal sewage from Sialkot City, which degrade the water quality and disrupt the ecological integrity. Present study was designed to highlight the effects of human activities on water quality and fish fauna of these streams. For this purpose, water samples and fish samples were collected at 18 sampling sites on seasonal basis from September 2004 to July 2006. Water samples were analyzed for 38 parameters. Hierarchical Agglomerative Cluster Analysis (HACA) identified three different classes of sites: relatively unimpaired, impaired and less impaired regions on the basis of variations in water quality parameters. Discriminant Function Analysis (DFA) identified 11 water quality parameters viz; stream flow, stream depth, DO, COD, TDS, NO 3- , PO 43- , Pb(dis), Cr(dis), Mg(sus), and Ni(sus), which showed significant spatial variations, whereas, major seasonal variations were observed in stream flow, temperature, EC, salinity, total hardness, Na(dis), K(dis), Ca(dis), Mg(dis), Fe(dis), Cd(dis), Cu(dis) and Na(sus). Factor Analysis (FA) identified the six sources of contamination such as municipal waste, industrial effluents, tanneries effluents, agricultural, urban runoff and parent rock material. COD, TDS, Fe (dis), Pb (dis), Cd (dis), Cr (dis) and Ni (dis) were found to be higher than the permissible limits. Seven heavy metals (Fe, Pb, Cd, Cr, Ni, Cu and Zn) were analysed in different organs (liver, gills, kidneys and muscles) of eight fish species. Significant variations in heavy metals accumulation were observed in organs of studied fish species. The concentration of Pb and Cr was recorded significantly between fishes captured from different sampling zones, whereas, Fe, Cd, Cr and Cu in fishes varied significantly between post monsoon and pre monsoon. The muscles of Channa punctata, Labeo rohita, Cirrhinus reba, Puntius sophore and Wallago attu captured from downstream of Nullah Aik and Nullah Palkhu exceeded the international permissible limits of Pb, Cd and Cr. A total of 24 fish species belonging to 12 families were recorded from Nullah Aik and Nullah Palkhu. Highest diversity indices were calculated at upstream of Nullah and downstream of Nullah Aik. Fish assemblage at upstream of Nullah Aik was stable, whereas, other stream segments showed seasonal variations. CCA identified the three groups of fishes viz., sensitive species, ubiquitous species and tolerant species, which were grouped on the basis of related to stream flow, stream depth, DO, COD, salinity, turbidity, NO 3- and heavy metals. Biological Integrity index xii(IBI) was developed for the assessment of stream ecosystem degradation. A total of 12 metrics were calculated on the basis of taxonomic richness, habitat preference, trophic guild, stress tolerance and origin of species to develop stepped and continuous IBI criteria. HACA segregated the sites based on species abundance into three groups viz., reference, moderately impaired and impaired groups. Non-Metric Multidimensional Scaling (NMDS) was applied to identify underlying ecological gradient to highlight the habitat degradation. Sites located in upstream of Nullah Aik showed higher IBI scores, which dropped to its lowest in downstream sites near Sialkot city, which gradually improve far downstream. Spatial variability in IBI values is related as a function of surface water quality degradation. The results indicate that water quality and fish fauna of these streams are facing severe degradation due to unwise anthropogenic in the catchment area. The findings of present study are alarming and highlight that there is an urgent need to protect the natural streams from further degradation. These results can be helpful for future management of other polluted streams and small rivers in the same eco-region.