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Genetic evaluation of CDKN2A P16 gene sequence variants in breast carcinoma

Thesis Info

Author

Ayesha Aftab

Supervisor

Sobia Tabassum; Abudl Hameed

Department

Department of Bioinformatics and Biotechnology

Program

MS

Institute

International Islamic University

Institute Type

Public

City

Islamabad

Province

Islamabad

Country

Pakistan

Thesis Completing Year

2016

Thesis Completion Status

Completed

Page

79

Subject

Bioinformatics & Biotechnology

Language

English

Other

MS 616.9944 AYG

Added

2021-02-17 19:49:13

Modified

2023-02-17 21:08:06

ARI ID

1676722404388

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جریبِ حیات

جریب حیات(افسانہ)

ڈاکٹر مجاہد عباس ،لیکچرر، نمل یونیورسٹی اسلام آباد

جریب زمین کے لیے ہے یا حیات کے لیے،  زمین اور حیات دونوں ہی اس سے ناواقف رہتی ہیں۔ البتہ انسان جو زمین سے اگایا جاتا ہے اور پھر زمین میں ہی دبایا جاتا ہے جریبوں کی  پیمائش بن کے رہ جاتا ہے۔

اقصیٰ کےلبوں پر  سَرمیلی بسنت کے پھول کھل رہے تھے۔اُس نے  زمین کی طرف جھکتے ہوئے اپنی زلف ِ دراز کو بائیں کان  کی اوٹ میں سُلا دیا اور زمین پر گرے کاغذ کو ہتھیلی پر رکھ کر دل میں اُتار لیا۔ اُسے اپنے پیلے لباس  کی مہک  وصل  کی چاندنی رات کا قصہ ِ ناتمام سنارہی تھی مگر وہ مسلسل سوچوں کی جریب سے پرائے موریے اور بورنیو کے جنگلات کی پیمائش کر رہی تھی۔وہ اُن جنگلات کے سحر انگیز مناظر میں یوں کھوئے جا رہی تھی  جیسے دین و دنیا کی متاع ِ بے پایاں اُسے نصیب ہو گئی ہو۔وہ ایک ایک پودے کے ایک ایک پتے کے ایک ایک  ملائم اور تیزکنارے کو چھو کر  اس کی خوشبو اور لطافت کو  جذب کر رہی تھی۔ وہ  خود کو  پرسکون سبز سمندر کی کشتی  سمجھ کر ہوا کے رخ پر دھیرے دھیرے رواں دواں تھی۔ ابھی اُس نے اپنی کمر سیدھی نہیں کی تھی کہ اسےگلی سے گزرتی ہوئی لاری کی آواز سنائی دی جس پر اے کلاس چنیوٹی فرنیچر  سلیقے سے لادا گیا تھا۔

 اس  نے ٹیَلوں لگے فرش سے پلاسٹک کی میز اور کرسیاں اٹھا کر گھر کی پچھلی طرف لان میں رکھ دیں جہاں پھولوں کے احاطے میں سبزے کی بہار تھی۔  یہ لان اس کی زندگی میں افضال کی طرح  اہمیت رکھتا تھا۔ وہ جب بھی تھک جاتی تو وہاں آرام کرتی تھی، پودوں...

قضية الترادف اللفظي والاتحاد المعنوي في اللسان العربي

In this article meaning of Taradif (synonymity) and identical meanings are treated from diverse aspects. Its implications in Arabic language have been particularly focused one. The article deals with different thoughts of lexicographers in this regard. There are some lexicographers who of the opinion that there does not exist any taraduf and different words are used for different meanings. For instance they do not believe that Saif(ÿ) and Sarim (rju>) have any Taraduf between them. In fact, according to them they are used for two different meanings and hence they do not give identical meanings. There is another group of lexicographers who are supporters of the existence of taraduf in Arabic language. In this regard they present the examples of existence of about 100 words for the meaning of "LION". Such as asad (J-I) Ghazanfar (>~ÿ) and daraghim etc. They also argue that denial of taradufcan lead to many linguistic problems. Such as how one can/would translate the phrase (v V) without need of rephrasing to the phrase of (v eiiV)

Hydro-Glaciological Modelling of Contrasting Hydrological Regimes of Upper Indus Basin under Ipcc Climate Change Scenarios Using Fully Distributed Topkapi Model

The water resources of the Upper Indus Basin (UIB) of Pakistan, are highly sensitive and vulnerable to climate change that can severely impact the food security and livelihood of millions living downstream. So it has become pertinent to understand the hydrometeorological behavior and assess future water resources and its variability under climate change scenarios. This study was designed to analyze the hydrometeorological trends and assess the changes in the contrasting hydrological regime of snow and glacier-fed river catchments of Hunza and Astore River basins of UIB under Intergovernmental Panel on Climate Change (IPCC) climate change scenarios. In this study, fully distributed TOPKAPI model has been used that incorporates the glaciers component and generates all hydrological cycle parameters at very high spatial and temporal scale. MODIS snow cover product (years 2001 to 2015) and field-based hydrological (19662012) and meteorological data (1999-2012) was used to investigate the trend and magnitude of hydrometeorological variables using nonparametric Mann–Kendall and Sen’s Slope methods. The TOPKAPI model was successfully calibrated and validated over five years 1999-2003 with a Nash coefficient ranging from 0.93-0.94. The representative concentration pathways (RCP) 4.5 and 8.5 scenarios of the IPCC were used to project the future trend of hydro-meteorological variables. The Astore River discharge and precipitation trend were significantly (p ≤ 0.05) increased with a Sen’s slope value of 1.039 m3·s−1·yr−1 and 0.192 mm·yr−1, respectively, while the temperature was non-significantly (p ≥ 0.05) increased with the Sen’s slope value of 0.041 °C·yr−1. On the other hand, the Hunza River discharge and temperature significantly (p ≤ 0.05) decreased with a Sen’s slope value of −2.541 m3·s−1·yr−1 and −0.034 °C·yr−1, respectively, while precipitation showed a non-significant (p ≥ 0.05) increasing trend with a Sen’s slope value of 0.023 mm·yr−1. The snow cover in Western Himalayas (Astore River basin) and Central Karakoram region (Hunza River basin) of the UIB had a stable and slightly increasing trend with a Sen’s slope of 0.07%.yr−1 and 0.394%.yr−1, respectively. Under RCP 4.5 and 8.5, the increasing trend in mean temperature was observed in study area with a value of 0.03 °C.yr1 and 0.12 °C.yr-1, respectively. Overall the increasing trend in annual discharge of Astore River and decreasing trend of snow cover was observed under RCPs. Whereas the Hunza River basin followed the same snow cover and discharge trend under RCP 8.5 while under RCP 4.5 the snow cover is decreasing with an increasing trend of the Hunza River discharge till 2070, and then decline in discharge was observed during far future scenario. Based on the results of this study, it can be concluded that since both sub-basins are influenced by different climatological systems (monsoon and westerly), therefore results of those studies where UIB is treated as one unit in hydrometeorological modeling should be used with caution. Furthermore, this study can help to resolve the Karakoram anomaly and potentially be utilized to develop water policy and planning new water harvesting and storage structures, to reduce the risk of flooding.