ہمایوں کبیر
افسوس ہے کہ گذشتہ مہینہ ہمایوں کبیر صاحب نے انتقال کیا، وہ اس دور کے لائق ترین مسلمانوں میں تھے اور اپنے ذوق کے اعتبار سے علمی و تعلیمی لائن کے آدمی تھے لیکن انھوں نے سیاست کا پُر خار راستہ اختیار کیا، اس لیے اس میں کامیاب نہ ہوسکے، علمی و تعلیمی لائن میں وہ زیادہ مفید کام انجام دے سکتے تھے، ان میں بعض خامیوں کے باوجود اسلامی حمیت پوری طرح موجود تھی جس کا اظہار ان کی تقریروں میں ہوتا رہتا تھا، وہ مولانا ابوالکلام کے شعبۂ میں رہ چکے تھے، اس لیے دارالمصنفین سے بھی واقف اور اس کے بڑے قدردان تھے، چنانچہ انھوں نے مولانا کے بعد بھی دارالمصنفین کے کاموں میں بڑی مدد پہنچائی، اب جو اور جیسا مسلمان بھی اٹھتا ہے، اس کا بدل نہیں مل سکتا، اس لیے ان کی جگہ بھی خالی رہے گی، اﷲ تعالیٰ ان کی خامیوں اور خطاؤں سے درگذر کرکے ان کی مغفرت فرمائے۔ (شاہ معین الدین ندوی، ستمبر ۱۹۶۹ء)
ROI is the Net Profit Margin multiplied by the asset turnover. Companies that develop this analysis system are often called the Du Pont system or ROI with the Du Pont approach. This study is a study to determine the level of performance. In this study, the variables to be studied are: Net Profit Margin, Asset Turn Over, Net Income and Total Asset as measured by the Du Pont Method. This study uses time series data for the last five years, so that the population of this study is also the research sample. Based on the considerations stated above, the authors are interested in conducting research with the title: "Analysis of Financial Performance Based on the Du Pont Method.
Small ruminants are important contributors to food production in Pakistan, particularly in the Federally Administered Tribal Areas (FATA) of Pakistan that have been badly affected by wars in the last 50 years. Sheep and goats could be infested with several species of ticks, which thereafter can transmit various pathogens, leading to economic losses due to morbidity and mortality of affected animals. Acaricide resistance is a major problem that hinders to control the disease burden caused by cattle tick, Rhipicephalus microplus in various parts of the world. Finding new molecules for efficient control of tick infestation is indispensable to maintain the cattle herd productivity thus reducing the economic losses. Very little is known about the genetic diversity of ticks of small ruminants in Pakistan, particularly in the FATA. Therefore, the current study is designed to assess genetic diversity of hard ticks infesting small ruminants in FATA and to record the resistance status against common commercial acaricides and efficacy of plant extracts against various developmental stages of ticks. A total of 1470 adult ticks were randomly collected from 294 host animals including Goats= 186 and Sheep=108. Eighty two samples out of 1470 samples of ticks were subjected to run PCR for each primer. Thirty samples were sent to sequencing for molecular identification of ticks. The expected amplicon sizes for 16S rRNA, cytochrome C oxidase 1 and ITS2 were observed from 460- 1600bp. The PCR amplicons for Rhiphicephalus, Hyalomma and Haemaphysalis were subjected for sequencing after purificat ion. Thirteen isolates of tick samples belong to different species for each primer were selected for the construction of phylogenetic trees. The alignment was done using BLAST and CLUSTAL W multiple alignment tools. While, resistance status and efficacy of methanol extracts of medicinal plants were assessed using Adult immersion test (AIT) and Larval packet test (LPT) as per recommended by FAO. Synergistic assays were also evaluated using LPT. Furthermore, in silico techniques were carried out to detect compounds in plants having acaricidal potential. Methanol extracts of leaves of Calotropis (C.) procera and roots of Taraxacum (T.) officinale were evaluated using adult immersion test and larval packet test against eggs, larvae and adults of Rhipicephalus microplus. Total nine species were identified, which include three species of genus Rhipicephalus (R. microplus, R. decolaratus and R. Sanguineus), two species of genus Haemaphysalis (Ha. sulcata and Ha. Punctata) and four species of genus Hyalomma (Hy. anatolicum, Hy. detritum, Hy. excuvatum and Hy. Scupense). DNA sequences of the above-mentioned ticks matched with those of respective published sequences available in the GenBank. These sequences were subjected to phylogenetic analysis using Mega 6 by Neighbor joining method with 1000 replication of bootstrap. The herbal extracts exhibited the lethal effects on egg laying (index of egg laying =0.2411±0.002, 0.275±0.001), hatching% (35.68±0.565, 33.40±0.311) and total larval mortalit y (96±0.57, 96.66±0.88) respectively, at 40 mg ml-1. Phenol 2 4-bis (1 1-dimethylethyl) and Squalene were found to be potent acetylcholinesterase inhibitors in plants. This study shows the diversity of ticks infesting small ruminants in the north-west parts of Pakistan. Findings of this study highlight the importance of using morphological and molecular approaches for identification of ticks. Herbal extract and synergistic assays exerted dose dependent response against all the developmental stages of R. microplus.