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Role of GATA -4 transcription factor associated with B-type natriuretic peptide in human heart failure

Thesis Info

Author

Khan, Fehmida Farid

Supervisor

Sobia Tabassum

Department

Department of Environmental Sciences

Program

BS

Institute

International Islamic University

Institute Type

Public

City

Islamabad

Province

Islamabad

Country

Pakistan

Thesis Completing Year

2011

Thesis Completion Status

Completed

Page

iv,63

Subject

Environmental Sciences

Language

English

Other

BS 612.405 KHR

Added

2021-02-17 19:49:13

Modified

2023-01-06 19:20:37

ARI ID

1676722616644

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پیر احسان اﷲ شاہ

پیر احسان اﷲ شاہ
علمی حلقوں میں یہ خبر غم و افسوس کے ساتھ سنی جائے گی کہ چھندم گوٹ ضلع حیدرآباد سندھ کے مشہور عالم پیر احسان اﷲ شاہ صاحب جو قلمی کتابوں کے بڑے عاشق تھے چوالیس برس کی عمر میں ۱۳؍ اکتوبر ۱۹۳۸؁ء کو اس دنیا سے چل بسے، مرحوم حدیث و رجال کے بڑے عالم تھے، اور ان کے کتب خانہ میں حدیث و تفسیر و رجال کی نایاب قلمی کتابوں کا بڑا ذخیرہ تھا، ان کے شوق کا یہ عالم تھا کہ مشرق و مغرب مصر و شام و عرب و قسطنطنیہ کے کتب خانوں میں ان کے کاتب اور ناسخ نئی قلمی کتابوں کی نقل پر مامور رہتے تھے، مرحوم ایک خانقاہ کے سجادہ نشین اور طریق سلف کے متبع، اور علم و عمل دونوں میں ممتاز تھے، اﷲ تعالیٰ مرحوم پر اپنے انوار رحمت کی بارش فرمائے۔ (سید سلیمان ندوی، نومبر ۱۹۳۸ء)

 

تعلیم کی اسلامی تشکیل نو ناگزىر ہے

Education system plays a vital role in personality development of an individual. That is why Allah ordained the Prophet (SAW) to develop personalities of his followers in light of the Holy Book. The education system prevailing in Pakistan today lacs Islamic perspective because it is continuation of the eduation system devised by the colonial power for its vested interests. It should have been reconstructed in light of Quran and Sunnah after creation of Pakistan but rulers and ulama both failed to do the needful. To do this job effectively all segments of education system, such as teachers, curriculum, educational administrators, students, and& nbsp; environment of the instituion need to be Islamized; rather a new role-model education institution has to be established. Those who decide to do this must be properly qualified for this hall mark task. This article discusses all these points in detail.

Salicylic and Abscisic Acid Induced Physiological and Biochemical Changes in Selected Wheat Cultivars under Heat Stress

High temperature is a crucial abiotic stress which limits yield in crop plant especially in wheat (Triticum aestivum) at post anthesis stages. Salicylic acid (SA) and abscisic acid (ABA) are the plant growth hormones which act as signaling molecules and confer stress tolerance in crop plants. Five wheat cultivars namely Pakistan-2013, NARC-2009, GA-02, Inqalab-91 and BAJ were assessed under heat stress by applying SA and ABA through seed priming and foliar application under field and in-vitro conditions. Effect of terminal heat stress on wheat was evaluated in filed by normal and late sowing. Normal sown crop escaped the terminal heat stress; while in late sowing, terminal heat stress negatively affected yield related traits and reduced yield by 25%, SA and ABA seed priming improved the grain yield 17% and 13% respectively. During in-vitro evaluation, exogenous SA and ABA application reduced the effects of heat stress, seed primed plants of both the hormones showed 13% and 15% higher yields under heat stress than the control. Heat stress affected physiological traits and reduced cell membrane stability, leaf relative water content, and total chlorophyll content. Foliar application of SA enhanced membrane stability, leaf relative water content and chlorophyll content by 32, 23 and 22% respectively and reduced the electrolyte leakage by 16%. Among the biochemical traits accumulation of soluble sugars, protein, proline content, hydrogen peroxide content and malondialdehyde content in the cells was increased, and antioxidant enzymatic activities were up-regulated under heat stress. Further 37, 74 and 87% elevated soluble protein, proline and soluble sugar content was observed in response to SA foliar. SA foliar application reduced hydrogen peroxide content and malondialdehyde content by 42 and 39% respectively. xxii Superoxide dismutase, peroxidase, ascorbate peroxidase and catalase activity was doubled under heat stress in response to SA and ABA seed priming as compared to control. Protein profiling and expression analysis was carried out for NAC transcription factors in response to heat stress and hormonal application. Several different heat shock proteins ranging from 50 to 98 kDa were produced under heat stress and in response to hormonal application in all selected cultivars. A novel heat shock protein of 60 kDa was expressed in NARC-2009 in response to salicylic acid seed priming whose sequence analysis identified it as a chaperone protein, RuBisCO large subunit-binding protein subunit alpha and beta (CPN-60 α and β). NAC transcription factors showed varied response to heat stress and hormonal application in all cultivars. Transcript level of TaNAC6B was higher under salicylic acid application in heat stress, and TaNAC67 was up-regulated by both salicylic and abscisic acid application during heat stress. TaNAC2D was up-regulated in NARC-2009 by salicylic and abscisic acid seed priming and by SA foliar application in GA-02. TaNAC6B, TaNAC67 and TaNAC2B showed higher transcript level in BAJ under all hormonal applications under heat stress. The expression of NAC transcriptional factors in response to salicylic acid and abscisic acid priming confirmed the positive role of these two hormones in enhancing tolerance against heat stress in tested wheat varieties including BAJ. These findings may be used to screen wheat cultivars through expression analysis against heat stress, develop heat tolerant cultivars and to improve performance of existing wheat cultivar against heat stress through hormonal priming.