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Pharmacophore-based virtual screening for identification of novel tyrosine kinase inhibitors and verification of inhibitory activity by molecular docking

Thesis Info

Author

Ayesha Gulrez

Supervisor

Asma Gul

Department

Department of Bioinformatics and Biotechnology

Program

BS

Institute

International Islamic University

Institute Type

Public

City

Islamabad

Province

Islamabad

Country

Pakistan

Thesis Completing Year

2013

Thesis Completion Status

Completed

Page

ix,137

Subject

Bioinformatics & Biotechnology

Language

English

Other

BS 616.01 AYP

Added

2021-02-17 19:49:13

Modified

2023-01-24 16:53:11

ARI ID

1676722666754

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پروفیسر خلیق احمد نظامی

پروفیسر خلیق احمد نظامی کی یاد میں
(پروفیسر اصغر عباسی)
’’نظامی صاحب بلند پایہ عالم اور ملک کے ممتاز مورخ اور دارالمصنفین کے رکن رکین تھے، ان پر بعض مشہور اہل قلم سے جن کو ان سے گہری واقفیت تھی، مضمون لکھنے کی فرمایش کی گئی ہے، اس مضمون میں ان کی زندگی کے ایک خاص پہلو ہی سے گفتگو کی گئی ہے‘‘۔ (ض)
خلیق احمد نظامی صاحب کے نام نامی سے میں علی گڑھ آنے سے پہلے ہی واقف ہوچکا تھا لیکن ملاقات ۱۹۶۸؁ء میں ہوئی جب راقم الحروف سرسید ہال کا طالب علم تھا اور وہ اس کے پرووسٹ مقرر ہوئے تھے۔
نظامی صاحب متوسط قد کے تھے لیکن ان کا جسم ایسا تھا کہ ہر لباس خواہ ہندوستانی ہو یا انگریزی ان پر خوب پھبتا تھا، ان کا رنگ گندمی تھا جس کی وجہ سے ان کے سفید بالوں کی جو قدرے لمبائی لیے ہوئے تھے سپیدی کا احساس بڑھ جاتا تھا۔ ان کی آنکھیں بڑی نہیں تھیں لیکن نہایت روشن تھیں جن میں ایک خاص چمک تھی، ان کے چہرے سے رعب عیاں ہوتا تھا لیکن خوف بالکل نہیں معلوم ہوتا تھا۔
نظامی صاحب مجسم علم تو تھے ہی لیکن ان کے سرتاپا عمل ہونے کا عقدہ اس وقت کھلا جب انہوں نے پہلی بار یونیورسٹی میں انتظامی عہدہ سنبھالا اور سرسید ہال میں پرووسٹ ہوکر آئے، ان کے زمانے میں ہال نے بڑی ترقی کی۔ میں اس کا عینی شاہد ہوں کہ وہ ہال کے دفتر میں حساب کا ایک ایک رجسٹر دیکھتے، مددگاروں کو انتظامات کی ایک ایک جزئی باتیں سمجھاتے انہیں راستہ بھی دکھاتے اور ایک ایک کام کی تاکید بھی کرتے اس کا نتیجہ یہ ہوا کہ ہال کے درد و دیوار سے لے کر اس کے سبزہ زار تک سب سرسبز اور شاداب ہوگئے۔ دراصل ہال کی...

معاصر خاندانی مسائل اور سیرت طیبہ کی روشنی میں ان کا حل

Family is a blessing from Allah Almighty. Family is the first institution of society which plays pivotal role in the moral, ethical and social development of an individual. But our contemporary family system has confronted with a number of religious social, and normal problems. Such pruners( چھانٹنا کانٹے( have enharossed our society from all caused and diffusing the moral and ethical values of society. It resulted in digestion of our family system. The degrade of entropy and chose is day by day in our society. However Islam outlays complete code of family life. It understands that it is the building foundation of every society so a clear guide as to how family structure should be built is outlined in detail in Islam. It is Provide a sample to solve all kinds of problems in the light of life of Hazrat Muhammad

Denoising and Segmentation of Blood Vessels in Retina Images Using Statistical Techniques

Visual pathology is one of the leading health complications in present day. The number of individuals with retinopathy signs has increased significantly in the recent years. Timely medications have produced favorable results in evading the visual deficiency. However, the exploration of retinal photographs is another option for periodical retinal treatment which is non-invasive. Various approaches have presented for inspection of the retinal photographs which are based on supervised techniques that utilize important distinctive features to be extracted from good quality retina images for training. In contrast, unsupervised methods perform exploration of the retinal image without the utilization of any trained information or human intervention. These type of models have been developed in this research. The proposed framework identifies an eye objects (e.g. optic disc, fovea and macula) in the first step. Later, these objects along with the background are eliminated from the retinal photographs in order to attain the retinal vascular map to locate the lesion manifestation. Inspired from the current research of retinal blood vessels segmentation, this dissertation introduces new approaches for localization of blood vessels in retina images. This research is focused on solving problems of the tiny vessels detection, manual threshold selection, computation complexity, degradation of accuracy with the change of the dataset, improper handling of pathological images, contrast enhancement, erroneous classification of blood vessels and denoising of retina images. The different preprocessing steps, contrast enhancement techniques, thresholding schemes, vasculature enhancement schemes and postprocessing techniques of vessels segmentation in retina images have been explored in this dissertation. Five new methods have been introduced for localization of the vascular map in retina images. The first two methods modify the basic thresholding techniques along with strong preprocessing and postprocessing steps. A third method also includes thresholding for blood vessels segmentation along with a novel scheme for contrast enhancement that makes the vessels more prominent from the background. These methods localized both wide and tiny vessels accurately and automatically of the different datasets. These methods are also robust against noise and various retinal disease abnormalities. Additionally, reduction in the computation complexity of all the methods is observed. Experimental results of the proposed methods have accomplished remarkable improvement in terms of accuracy, sensitivity, specificity and area under the curve (AUC). The last two proposed methods introduced parallel steps for noise elimination, vasculature enhancement and segmentation. Initially, vessels location map (VLM) is extracted by utilizing various preprocessing and thresholding techniques. Then vasculature based enhancement is achieved by applying B-COSFIRE filter and Frangi’s filter in each method individually. In the first step of both methods, background noise and geometrical objects (e.g. optic disk, macula, fovea, etc.) are removed. Thus, VLM is obtained by identifying wide vessels positions to couple with the output image of the second step. The proposed methods have shown better accuracy, sensitivity and specificity when compared to existing methods. The proposed methods of this dissertation can indeed contribute to the development of an automatic retinal vessel segmentation system capable of handling both healthy and unhealthy images of all datasets.