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Fundamental & technical analysis of textile industry : a comparative study

Thesis Info

Author

Farhana Bukhari

Supervisor

Mariam Irfan

Department

Department of Business Administration

Program

MBA

Institute

International Islamic University

Institute Type

Public

City

Islamabad

Province

Islamabad

Country

Pakistan

Thesis Completing Year

2015

Thesis Completion Status

Completed

Page

Mics, ages

Subject

Business Administration

Language

English

Other

MA/MSc 677.009757 FAF

Added

2021-02-17 19:49:13

Modified

2023-01-06 19:20:37

ARI ID

1676722700934

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ڈ اکٹر خورشید احمد فارق

ڈاکٹر خورشید احمد فارق
(مختارالدین احمد)
دو شنبہ، ۱۸؍ شعبان المعظم ۱۴۲۲؁ھ مطابق ۵؍ نومبر ۲۰۰۱؁ء کی صبح کو عربی زبان و ادب کے استاد، تاریخ اسلام کے ماہر اور ممتاز مصنف ڈاکٹر خورشید احمد فارق کوئی ۸۵ سال کی عمر میں طویل علالت کے بعد دہلی میں وفات پاگئے۔
وہ ۱۹۱۶؁ء میں بریلی میں پیدا ہوئے۔ فارسی و عربی کی متد اول کتابیں انھوں نے گھر پر اپنے والد ماجد سے پڑھیں۔ کالج کی تعلیم انھوں نے بریلی میں حاصل کی۔ ایم۔اے اور پی۔ایچ۔ڈی انھوں نے مسلم یونیورسٹی علی گڑھ سے کیا۔ ریسرچ کے دوران وہ شعبہ عربی میں کچھ کلاسیں بھی لیتے رہے۔ ۱۹۴۳؁ء کے اواخر میں وہ اینگلو عربک کالج دہلی میں لکچرر، ۱۹۵۳؁ء کے اواخر میں دہلی یونیورسٹی میں ریڈر مقرر ہوئے۔ اکتوبر ۱۹۵۶؁ء میں حکومت ہند کے ایک وظیفے پر ایک سال کے لیے وہ مصر گئے۔ وہاں دارلکتب المصریہ کے مخطوطات کے مطالعے کا انہیں اچھا موقع ملا۔ ریاض الرحمن خاں صاحب شروانی اور عبدالحلیم ندوی صاحب کو بھی اسی سال یہ وظیفہ ملا تھا۔ قاہرہ میں ان تینوں کا خوب ساتھ رہا۔ فروری ۱۹۶۹؁ء میں وہ دہلی یونیورسٹی میں پروفیسر اور صدر شعبہ مقرر ہوئے۔ جولائی ۱۹۸۵؁ء میں وہ متقاعد ہو کر علی گڑھ آگئے اور سر سید نگر میں اپنے تعمیر کردہ مکان ’’بانس کلی‘‘ میں مقیم ہوکر علمی و ادبی کاموں میں مصروف ہوگئے۔ آخر عمر میں وہ اپنے بچوں کے پاس دہلی چلے گئے تھے، وہیں ان کی وفات ہوئی۔ جامعہ ملیہ اسلامیہ کے قبرستان میں ان کی تدفین عمل میں آئی۔
ڈاکٹر فارق نے اردو، انگریزی اور عربی میں عربی اور تاریخ اسلام کے موضوعات پر متعدد کتابیں لکھیں اور کثرت سے مضامین سپرد قلم کیے جو زیادہ تر رسالہ ’’برہان‘‘ دہلی میں شائع ہوئے۔ ان کی تصانیف حسب ذیل ہیں:
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Kras Oncogenic Mutation Pattern in Pakistani Patients Presenting With Colorectal Adenocarcinoma in a Northern Tertiary Referal Centre

Veterinary Pathology Pathology Abstract Colorectal cancer is a global disease with marked morbidity and mortality. Involvement of genetic and environmental factors produces variability in its prevalence. KRAS (Kirsten rat sarcoma viral oncogene homologue) is one of the important genes responsible for sporadic CRC. The constitutive GTPase activity of the gene is lost when it gets mutated and so the deregulated cells undergo unrestricted proliferation leading to oncogenesis. From therapeutic point of view, patients with KRAS mutations do not benefit from epidermal growth factor receptor inhibition drugs as those who possess normal KRAS. The analysis of KRAS mutations is therefore important from both diagnostic as well as therapeutic purposes. Diagnostic methodology and the valuable information of this study will be quite helpful in future. The objectives of this study were to document the KRAS oncogenic mutation pattern mostly in Northern Pakistani residents presenting in AFIP, Rawalpindi after their intestinal resection due to CRC. The other objective was to relate this mutation pattern with histopathological categorical variables like age, gender, presenting clinical complaint, tumor site, size, histological differentiation, modified Duke Stage of tumor, nodal metastasis and metastasis in other organs. Hundred and eighty one cases of CRC from persons residing in northern area of Pakistan were collected and observed for the above mentioned parameters. DNA was extracted from the tumors and normal tissues of all the study subjects. PCR was done for gene amplification and the status of KRAS mutations in Pakistani CRC patients was analyzed by gene sequencing. The results showed more prevalence of CRC in the males of northern areas of Pakistan. Both males and females with higher average age had high tendency to acquire CRC. Rectum was found to be the most common location of CRC, followed by sigmoid. Exophytic well differentiated adenocarcinomas were the most common form of CRC. Gene sequencing did not show even a single KRAS mutation in the tested samples. It can be inferred from this study that either there is no KRAS mutation in northern area patients suffering from CRC or the mutation frequency of this particular gene is relatively very low as compared to the results of studies reported in the literature. A wider scale study of these patients may prove the cause of CRC to be due to mutation of some other genes or may be due to some non-genetic factors.