Determinant Factors Affecting Intention of Child Marriage to Adolescents in Banggai Laut

This study aims to look at the determinant factors that affect the intense / intention to do child marriage to adolescents in Banggai Laut. This research method using a cross sectional study. The research sample consisted of 192 teenage students in SMA Negeri 1 Banggai and SMA Negeri 2 Banggai. Chi-square test and multiple logistic regression were used to analyze the data. The results of the bivariate analysis showed that there was an effect of attitude, family drive and behavior control on the intention to do child marriage (p <0.05). The results of the multivariate analysis showed that there was only one variable that had a p value <0.05, namely the family drive variable with p = 0.029. From exp (B) = 4,871> 1 is a risk factor and the Cl value is 95% more than 1 (1,178-20,142) so that OR is significant. This means that respondents who are influenced by family encouragement have a risk of 4,871 times having the intention of engaging in child marriage. It can be concluded that there are many factors that can influence adolescents in engaging in child marriage. All levels of society should protect children together and stop the practice of child marriage in society. The smallest and closest family unit for the child should be able to protect it, not be the main factor that encourages underage marriage.

Development of Novel Radiopharmaceutical for Cancer Diagnosis and Sentinel Node Detection

This study was undertaken to develop the novel radiopharmaceuticals for cancer diagnosis, sentinel lymph node detection (SLND), and brain imaging. Biomolecules have great importance in living systems. Significantly, developed pathway is available for transport and utilization of biomolecules and by taking the advantages of these naturally developed pathways. In this study, the biomolecules like triglycine, 1-azido-1-deoxy-β-D glucopyranoside and folate azide were utilized for various medicinal applications. Biomolecule conjugates were developed by using click chemistryand cyclopentadienyl chemistry (Cp) approach. The spectrophotometric biomolecule complexes techniques. conjugates were were By characterized using radiolabeled the and by using various [ 99m Tc(H 2 O) 3 (CO) 3 ] + evaluated as core, potential radiopharmaceuticals for diagnostic study. The biodistribution of [ 99m Tc(CO) 3 - click-1-azido-1-deoxy-β-D glucopyranoside] and [ 99m Tc(CO) 3 -folate azide] complexes present them as potential tumor scintigraphic agents. Second approach for cancer diagnosis was to radiolabel the anticancer drugs, e.g., 5-fluorouracil and methotrexate with technetium-99m ( 99m Tc) and evaluate them as potential tumor diagnostic agents. Normal biodistribution and tumoral uptake was studied in Swiss webster mice. The results suggest that they might be sucessful tumor diagnostic agents for future use. 99m Tc-5-flurouracil was also applied to the breast cancer patients after getting approval from local ethical committee of INMOL. The sucessful uptake of the drug in tumor tissues with low background ratio presents this drug as a sucessful cancer diagnostic agent. Sentinel Lymph Node Detection (SLND) is of great importance for early stage diagnosis of cancer. All sentinel lymph node imaging agents were studied for their uptake in various body organs, popliteal node, iliac node and popliteal extraction.In this study, we developed rhenium sulfide collidal nanoparticles and xviiiAbstract radiolabeled them with 99m Tc. The sucessful uptake of the drug in sentinel node within 15 min of post injection, presents it as a sucessful candidate for sentinel lymp node detection. Various dextran derivatives were radiolabeled with 99m Tc(CO) 3 and studied for sentinel lymph node detection. The drugs reached the first node within 10 min of post injection. DPZM-8 was the most successful candidate for sentinel lymph node detection among all dextran derivatives studied, so far. 99m Tc-labeled amine thiophene and 99m Tc(CO) 3 -Cp-triglyicne were evaluated as potential brain imaging agents. Amine thiophene is a schiff base which was directly labeled with 99m was radiolabeled with Tc while Cp-triglycine is a biomolecule conjugate which 99m Tc via isolink kit. Normal distribution study in rabbits suggests them as successful candidates for brain scintigraphy.