كمال التحقيق في ترجمة نبي الله يوسف الصديق

This study sheds light on the life of an important figure that has had a great impact on humanity throughout history and that is the personality of Prophet Yūsuf Al-Siddīq “Joseph the Truthful”، peace and blessings of God be upon him. Since sources cited different narratives revolving around the events in the Prophet’s life، the researchers aimed to explore such events in the archived sources pertaining to his life. The inductive comparative method was used to conduct this thorough study of Prophet Joseph’s biography. Having defined the meaning of the name of the Prophet Yūsuf Al-Siddīq “Joseph the Truthful”، the names of the Prophet’s ancestors were traced and explored based upon a documented proof of his genealogical ancestry. The study also sheds light on the Prophet’s homeland where he was born and raised.  The study also explores the qualities of beauty that God bestowed on Prophet Joseph. Moreover، the study also discusses the Prophet’s morals، ethics and disposition. The study concludes with an investigation into the marriage of Prophet Joseph، peace be upon him.

Study of Xanthine Oxidase Inhibitory Potential of Natural Products Extracted from Medicinal Plants and Synthesized Benzothiazine Derivatives.

Present work consists of screening of Croton sparsiflorus (Euphorbiaceae), Laggera aurita (Asteraceae) and synthesized benzothiazine derivatives for their xanthine oxidase inhibitory potential. Extraction and bioassay guided isolation of Croton sparsiflorus resulted in the identification of eleven compounds. Three compounds were purified and identified as crotsparinine (8), crotsparine (9) and sparsiflorine (10). Sparsiflorine (10) was the most active XO inhibitor from Croton sparsiflorus with IC 50 value of 18.0 ± 0.4 μM followed by crotsparine (9) and crotsparinine (8). Twelve compounds were also identified from Laggera aurita but only two were purified and subjected to XO inhibition potential namely 2,4-di-tert-butylphenol (21) and 2,4-ditert-butyl-6-nitrophenol (22) with IC 50 values of 43.2 ± 1.9 μM and 40.2 ± 1.2 μM respectively. Both the isolated compounds from L. aurita inhibited XO strongly. Out of thirteen synthesized benzothiazine derivatives twelve contain 1,4- benzothiazine nucleus. This nucleus is quite familiar to natural products. These derivatives were characterized by EIMS, 1 H-nmr and XRD analysis as 2H-1,4- benzothiazin-3(4H)-one (24), 2H-1,4-benzothiazin-3(4H)-one 1,1-dioxide (25), ethyl 4- hydroxy-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide (27), (3-oxo-3,4-dihydro-2H- 1,4-benzothiazin-2 yl)acetic acid (28), ethyl (3-oxo-3,4-dihydro-2H-1,4-benzothiazin-2- yl)acetate (29), ethyl 3-oxo-3,4-dihydro-2H-1,4-benzothiazine-2-carboxylate (30), ethyl (1,1-dioxido-3-oxo-3,4-dihydro-2H-1,4-benzothiazin-2-yl)acetate (31), 2-(3-oxo-3,4- dihydro-2H-1,4-benzothiazin-2-yl)-N-phenylacetamide (32), N-cyclohexyl-2-(3-oxo-3,4- dihydro-2H-1,4-benzothiazin-2-yl)acetamide (33), 1-(3-methyl-4H-1,4-benzothiazin-2- yl) ethanone (34), ethyl 3-methyl-4H-1,4-benzothiazine-2-carboxylate (35), ethyl (2E)- 2H-1,4-benzothiazin-3(4H)-ylideneacetate (36) and 2-benzoyl-2H-1,4-benzothiazin- 3(4H)-one (37). They showed little to moderate XO inhibition potential with [(3-oxo-3,4- dihydro-2H-1,4-benzothiazin-2 yl)acetic acid (28) as the most active followed by 2H-1,4- benzothiazin-3(4H)-one (24)] { IC 50 values of 124.2 ± 13.9 μM and 212.7 ± 16.4 μM respectively }.